CAREER: Neuro-navigation guided non-invasive brain stimulation for individualized precision rehabilitation in stroke

职业：神经导航引导的非侵入性脑刺激用于中风的个体化精准康复

• 批准号: 2236459
• 负责人: Yuan Yang
• 金额: $ 59.59万
• 依托单位: University of Oklahoma Norman Campus
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2023-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2236459&HistoricalAwards=false
• 关键词: CAREER; Neuro; navigation; guided; non

The goal of this project is to advance the scientific study of brain functional changes after a stroke and pioneer a tailored rehabilitation strategy that fits each individual’s needs. Movement impairments following a stroke are a major cause of adult disability in this country. The routine treatment is not yet optimal for every individual due to a lack of sufficient understanding of brain functional changes to inform clinical practice. This project seeks to combine different imaging methods to guide electrical stimulation to the brain that improves the recovery of movement. The outcomes of this project have the potential to advance stroke or brain injury research broadly to help over half a million people who undergo rehabilitation each year. This will reduce the healthcare and nursing costs for long-term disability caused by stroke and other similar brain injuries. Through education activities in this project, a multi-disciplinary research-education “eco-system” will be built to connect engineering students, clinician trainees, and STEM educators to promote the education of next-generation rehabilitation pioneers. Despite numerous efforts to develop new technologies for movement rehabilitation post-brain injuries, from brain imaging to neuromodulation approaches, optimal recovery is still limited due to a lack of imaging guidance and real-time neurofeedback to tailor rehabilitation strategies for each individual. This project will address this limitation and establish a unique rehabilitation engineering research paradigm based on a novel multi-modal brain imaging approach and a closed-loop high-definition transcranial direct current stimulation (HD-tDCS) platform. This new approach will precisely assess the changes to motor control in an injured brain and identify the key network to target for more precise HD-tDCS stimulation. The investigator will take integrated experimental and computational approaches to: 1) Identify and characterize individualized brain networks for movement control in injured brains; 2) Model and evaluate the dynamic effect of HD-tDCS on a “live” brain to enable targeted, precision stimulation of brain networks; and 3) Develop closed-loop imaging and neurofeedback guided HD-tDCS to improve brain function and behavior outcomes. This interdisciplinary project will be integrated with education and outreach activities to promote awareness of interdependencies between engineering and rehabilitation sciences and promote interdisciplinary education and training for next-generation rehabilitation engineers, with three educational objectives: 1) Promote the engagement of engineering and physical therapy students via summer research training, 2) Translate rehabilitation engineering knowledge to grade-appropriate STEM education via training high school teachers, and 3) Increase public awareness of engineering’s contributions to rehabilitation via museum events.This project is jointly funded by the Disability and Rehabilitation Engineering Program and the Established Program to Stimulate Competitive Research (EPSCoR).This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目的目标是推进对中风后大脑功能变化的科学研究，并开创适合每个人需求的定制康复策略。中风后的运动障碍是该国成人残疾的主要原因。由于缺乏对大脑功能变化的充分了解来指导临床实践，该项目尚未对每个人都达到最佳效果，该项目旨在结合不同的成像方法来引导对大脑的电刺激，从而改善运动的恢复。广泛推进中风或脑损伤研究的潜力，以帮助克服通过该项目的教育活动，每年有 50 万人接受康复治疗，这将减少因中风和其他类似脑损伤而导致的长期残疾的医疗和护理费用。尽管人们在开发脑损伤后运动康复的新技术（从脑成像到神经调节方法）方面做出了许多努力，但该项目将旨在连接工程专业学生、临床医生实习生和 STEM 教育工作者，以促进下一代康复先驱的教育。由于缺乏影像引导，仍然受到限制该项目将解决这一局限性，并基于新型多模态脑成像方法和闭环高清经颅直流电刺激建立独特的康复工程研究范式。这种新方法将精确评估受伤大脑运动控制的变化，并确定目标网络以进行更精确的 HD-tDCS 刺激。研究人员将采用综合实验和计算方法来：1）识别。并表征用于受伤大脑运动控制的个性化大脑网络；2) 建模并评估 HD-tDCS 对“活体”大脑的动态影响，以实现大脑网络的定向、精确刺激；3) 开发闭环成像和神经反馈引导 HD -tDCS 旨在改善大脑功能和行为结果。这个跨学科项目将与教育和外展活动相结合，以提高对工程和康复科学之间相互依赖性的认识，并促进下一代康复工程师的跨学科教育和培训，其教育目标有三个： 1) 通过暑期研究培训促进工程和物理治疗学生的参与，2) 通过培训高中教师，将康复工程知识转化为适合年级的 STEM 教育，3) 通过博物馆活动提高公众对工程对康复贡献的认识。该项目由残疾与康复工程计划和刺激竞争性研究既定计划 (EPSCoR) 联合资助。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准。