FMSG: DNA-based Assembly of Manufacturable NanoElectronic Device

FMSG：基于 DNA 的可制造纳米电子器件组装

• 批准号: 2036865
• 负责人: Joshua Hihath
• 金额: $ 50万
• 依托单位: University of California-Davis
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-15 至 2023-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2036865&HistoricalAwards=false
• 关键词: FMSG; DNA; based; Assembly; Manufacturable

The vision of this project is to produce a framework for the long-term expansion of manufacturable DNA-based electronics in society, leveraging advances in DNA nanotechnology, synthetic biology, and nanoscale electronics, in addition to developing a workforce appropriately trained to advance the field. The invention of DNA nanotechnology in the United States (US) nearly 40 years ago combined with the significant advances made in leading US universities over the last 15 years, has put DNA nanotechnology near a tipping point, similar to the state of semiconductor technology in the 1950’s and 60’s. To succeed in bringing DNA nanotechnology to a manufacturing threshold, several technological, fundamental, and human resource advances are required: (i) computer aided design (CAD) tools to model their folding and electronic properties in use-case environments, (ii) scalable methods for the placement of DNA nanostructures must be expanded; (iii) robust, stable, electrical contacts must be scaled to manufacturable levels; (iv) growth and assembly of DNA origami scaffolds must be optimized and scaled to production levels; and (v) groundwork for the development of a workforce that is trained with the interdisciplinary skills necessary to address challenges across a wide breadth of disciplines. This seed grant will focus on research topics related to defining the framework for these issues, developing processes for manufacturing these systems, developing a workforce for their implementation, and defining partnerships for moving forward. The development of a manufacturing framework for DNA-based electronic systems, and the knowledge gained from this transdisciplinary project will have a direct impact on a variety of fields. It will allow the development of new frontiers for DNA nanostructures in applications beyond electronics; enable new paradigms for the continued exponential growth of the semiconductor industry; open new applications and capabilities for US-based manufacturing; open new avenues for DNA nanostructures in biology, optics, and medicine; and help prepare a workforce inclusive of diverse backgrounds (community colleges, four-year colleges and research universities) to be able to work in this field. This project presents a convergent, interdisciplinary approach to developing a foundation for manufacturing DNA-based electronics. This seed grant will use DNA-based cross-wire memory elements as the target device, and focus on addressing key roadblocks to manufacturing these systems. These include: (i) the development of CAD tools for designing memory element origami-based architectures, and modeling the electronic properties of DNA-based structures; (ii) the design of DNA nanostructures and their connection to lithographically defined contacts for readout via a combination of chemical and electronic attachment paradigms; (iii) the development of scalable methods for assembling DNA nanostructures at defined locations within a circuit by controlling surface interactions and using dielectrophoretic placement controls; and (iv) the development of a framework that will allow a workforce to be trained with sufficient background in synthetic biology, DNA nanotechnology, nanoscale electronics, and manufacturing to help move this field from a leading-edge research platform to a foundational manufacturing platform.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目的愿景是为社会中的基于DNA的电子产品的长期扩展，利用DNA纳米技术，Synthetic Biology和Nansoscale Electronics的长期扩展，除了开发经过适当培训以促进该领域的劳动力外。大约40年前，美国（美国）DNA纳米技术的意图与过去15年来领先美国大学所取得的重大进展相结合，使DNA纳米技术在临界点附近，类似于1950年代和60年代半导体技术的状态。为了成功将DNA纳米技术带入制造阈值，需要几种技术，基本和人力资源的进步：（i）计算机辅助设计（CAD）工具，以建模其在用例环境中的折叠和电子特性，（ii）必须扩展DNA纳米结构放置的可扩展方法； （iii）必须将稳定，稳定的电触点缩放到制造水平； （iv）必须优化DNA折纸支架的生长和组装，并缩放到生产水平； （v）开发劳动力的基础工作，该劳动力受过培训，以应对各个学科的挑战所需的跨学科技能。这项种子赠款将重点关注与定义这些问题框架，开发制造这些系统的流程，为实施的劳动力以及定义前进的合作伙伴关系的研究主题。为基于DNA的电子系统制造框架的开发以及该跨学科项目所获得的知识将对各种领域产生直接影响。它将允许在电子产品以外的应用中开发用于DNA纳米结构的新边界；为半导体行业的持续指数增长启用新的范式；开放基于美国制造的新应用和功能；开放生物学，光学和医学中DNA纳米结构的新途径；并帮助准备包括潜水员背景（社区学院，四年制学院和研究所）的劳动力，以便能够在这一领域工作。该项目提出了一种融合的跨学科方法，用于为制造基于DNA的电子产品开发基础。该种子赠款将使用基于DNA的跨线记忆元素作为目标设备，并专注于解决制造这些系统的关键障碍。其中包括：（i）开发用于设计基于内存元素的折纸架构的CAD工具，并建模基于DNA的结构的电子特性； （ii）DNA纳米结构的设计及其连接到印度定义的触点，通过化学和电子附着范式的组合进行读数； （iii）通过控制表面相互作用和使用介电摄取的放置控件来开发用于在电路内定义的位置组装DNA纳米结构的可扩展方法； （iv）开发将允许劳动力在合成生物学，DNA纳米技术，纳米级电子和制造业方面进行足够背景培训的框架，以帮助将该领域从领先的研究平台转移到基础制造平台上，这反映了NSF的法定任务和审查的范围，这是通过评估的范围来进行的，这表明了良好的范围。

项目成果

Review of Dielectrophoretic Manipulation of Micro and Nanomaterials: Fundamentals, Recent Developments, and Challenges

• DOI: 10.1109/tbme.2022.3183167
• 发表时间: 2023-01-01
• 期刊: IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
• 影响因子: 4.6
• 作者: Ghomian, Taher;Hihath, Joshua
• 通讯作者: Hihath, Joshua

Classification of DNA Sequences: Performance Evaluation of Multiple Machine Learning Methods

DNA 序列分类：多种机器学习方法的性能评估

• DOI: 10.1109/nano54668.2022.9928773
• 发表时间: 2022
• 期刊: IEEE
• 作者: Wang, Yiren;Khandelwal, Vikram;Das, Arindam K.;Anantram, M.P.
• 通讯作者: Anantram, M.P.

Quantum transport in conductive bacterial nanowires

导电细菌纳米线中的量子传输

• 发表时间: 2022
• 期刊: 2021 IEEE 16th Nanotechnology Materials and Devices Conference (NMDC
• 作者: William Livernois, MP Anantram

Self-Aligning Nanojunctions for Integrated Single-Molecule Circuits

• DOI: 10.1021/acsnano.3c10844
• 发表时间: 2024-01-12
• 期刊: ACS NANO
• 影响因子: 17.1
• 作者: Liu，Bo;Demir，Busra;Hihath，Joshua
• 通讯作者: Hihath，Joshua

Thickness-Dependent Seebeck Coefficient in Hybrid 2-Dimensional layers

混合二维层中厚度相关的塞贝克系数

• DOI: 10.1109/nmdc50713.2021.9677528
• 发表时间: 2021
• 期刊: 2021 IEEE 16th Nanotechnology Materials and Devices Conference (NMDC
• 作者: Ghomian, Taher;Darwish, Nadim;Hihath, Joshua
• 通讯作者: Hihath, Joshua