RAPID: COVID-19: New Handheld Gas Sensors for Airborne SARS-CoV-2 Virus: Instant COVID-19 Diagnosis from Exhaled Breath

RAPID：COVID-19：针对空气传播的 SARS-CoV-2 病毒的新型手持式气体传感器：通过呼出气体进行即时 COVID-19 诊断

• 批准号: 2031153
• 负责人: Jeremy Luban
• 金额: $ 10万
• 依托单位: University of Massachusetts Medical School
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2031153&HistoricalAwards=false
• 关键词: RAPID; COVID; 19; New; Handheld

Infectious SARS-CoV-2 can persist in air for hours and on surfaces for days, threatening the lives of the general public, and of hospital staff. To address the challenges in the diagnosis of COVID-19, the two principal investigators (PIs) Nian Sun from Northeastern University and Jeremy Luban from UMass Medical School will develop a handheld gas sensor for SARS-CoV-2 virus in air, which will instantly detect SARS-CoV-2 in 1~2 seconds in exhaled breath and on surfaces, based on their demonstrated success on different gas sensors. Compared to other state-of-the-art technologies in the market for COVID-19 diagnosis, the proposed electrochemical sensor has multifold advantages, including ultra-high sensitivity and extreme selectivity, low-cost, and fast response and recovery. This work on novel electrochemical sensors for SARS-CoV-2 virus detection in air represents significant advancement in fundamental research on electrochemical sensors which are typically designed for molecules with much smaller sizes. These sensors will provide instant point of care diagnosis for COVID-19 and could be readily adapted for diagnosis of other diseases through sensing different biomarker chemicals. These proposed SARS-CoV-2 sensors are novel electrochemical sensors with templated vacancies of SARS-CoV-2 particles, which leads to extremely high selectivity, sub-part per quadrillion (sub-ppq) sensitivity which is 6~9 orders of magnitude better than competitive gas sensors, fast sensor response and recovery time of 1~2 seconds, and long durability of over one year in different temperature and humidity environments. The two PIs have complementary expertise and resources needed for this project on sensors and electronics engineering (Sun), and on virus, proteins, biochemistry and molecular pharmacology (Luban). The PIs plan to carry out research tasks to include fabrication of SARS-CoV-2 gas sensors, sensitivity test, specificity test, and test specificity and sensitivity of SARS-CoV-2 sensors for spike protein variants that appear over the course of the pandemic. The iterative sensor fabrication and tests will be conducted to improve the sensor sensitivity and specificity of the gas sensors with SARS-CoV-2 and with control viruses, and to enable the SARS-CoV-2 sensor tests in ICUs and on humans for COVID-19 diagnosis.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

传染性的SARS-COV-2可以在数小时内持续数小时，数天，威胁了公众和医院工作人员的生命。为了应对Covid-19诊断的挑战，来自东北大学的两名主要研究人员（PIS）Nian Sun和UMass医学院的Jeremy Luban将开发出空气中SARS-COV-2病毒的手持式气体传感器，这将立即在呼吸呼吸和表面上的1〜2秒内立即检测出SARS-COV-2，并基于他们的表面上的表现出色，并取得了不同的燃气。与COVID-19诊断市场中其他最先进的技术相比，拟议的电化学传感器具有多重优势，包括超高敏感性和极端选择性，低成本以及快速的反应和恢复。这项针对空气中SARS-COV-2病毒检测的新型电化学传感器的工作代表了电化学传感器的基本研究的显着进步，这通常是针对尺寸较小的分子而设计的。这些传感器将对COVID-19提供即时的护理点诊断，并且可以通过感应不同的生物标志物化学物质来容易适应其他疾病。这些提出的SARS-COV-2传感器是新型的电化学传感器，具有SARS-COV-2颗粒的模板空缺，导致非常高的选择性，每四十四（子-PPQ）敏感性，该敏感性比竞争性气体传感器的响应时间更好，快速传感器的响应时间和长度较长的持续时间和持久的持续时间差异为6〜9个范围，均高于竞争性的气体传感器。这两个PI具有有关传感器和电子工程（SUN）以及病毒，蛋白质，生物化学和分子药理学（LUBAN）（LUBAN）所需的互补专业知识和资源。 PIS计划执行研究任务，包括制造SARS-COV-2气体传感器，灵敏度测试，特异性测试以及SARS-COV-2传感器对大流行过程中出现的SPIKE蛋白变体的特异性和灵敏度。将进行迭代传感器制造和测试，以提高使用SARS-COV-2和对照病毒的气体传感器的传感器敏感性和特异性，并启用ICU中的SARS-COV-2传感器测试，并在ICU和人类上进行COVID-19的诊断。这一奖项反映了NSF的法定任务和审查的依据，这表明了审查的范围。