CAREER: Transforming Multi-parametric Photoacoustic Microscopy

职业：改变多参数光声显微镜

• 批准号: 2023988
• 负责人: Song Hu
• 金额: $ 47.47万
• 依托单位: Washington University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2023988&HistoricalAwards=false
• 关键词: CAREER; Transforming; Multi; parametric; Photoacoustic

This project aims to transform microscopy from the current low-speed benchtop system into the first-of-a-kind high-speed miniature/portable device that will enable wearable, handheld applications. The microscope will include many of the currently available separate optical modalities into a single multi-parameter system. The proposed system will retain these modalities with no reduction in performance yet with improved portability, reduction in size, and increased data collection efficiency for functional imaging capabilities. This breakthrough is expected to find broad applications in areas spanning from neuroscience to clinical treatment of cancer, personalized screening of cardiovascular drugs, and management of wound healing. The technology developed in this program will significantly expand the scope of multi-parametric PAM beyond basic research in anesthetized of restrained animals. The multidisciplinary nature of the proposed research involving optical and mechanical design, numerical simulation, microfabrication, data processing, instrument development and testing will offer well-balanced training opportunities for all participants.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目旨在将显微镜从当前的低速台式系统转变为首先的高速微型/便携式设备，该设备将启用可穿戴的手持式应用。显微镜将在单个多参数系统中包括许多当前可用的单独的光学模式。所提出的系统将保留这些方式，而尚未降低性能，但可移植性提高，大小降低以及功能成像功能的数据收集效率提高。预计这一突破将在从神经科学到癌症临床治疗，心血管药物的个性化筛查以及伤口愈合的管理方面找到广泛的应用。该计划中开发的技术将大大扩展多参数PAM的范围，而不是被约束动物麻醉的基础研究。拟议的研究的跨学科性质涉及光学和机械设计，数值模拟，微型制作，数据处理，仪器开发和测试将为所有参与者提供良好的平衡培训机会。该奖项反映了NSF的法定任务，并通过使用该基金会的知识绩效和广泛的影响来评估NSF的法定任务，并被视为值得的支持。

项目成果

Development of a photoacoustic microscopy technique to assess peritubular capillary function and oxygen metabolism in the mouse kidney

开发光声显微镜技术评估小鼠肾脏管周毛细血管功能和氧代谢

• DOI: 10.1016/j.kint.2021.06.018
• 发表时间: 2021
• 期刊: Kidney International
• 影响因子: 19.6
• 作者: Sun, Naidi;Zheng, Shuqiu;Rosin, Diane L.;Poudel, Nabin;Yao, Junlan;Perry, Heather M.;Cao, Rui;Okusa, Mark D.;Hu, Song
• 通讯作者: Hu, Song

Temporal and spectral unmixing of photoacoustic signals by deep learning.

• DOI: 10.1364/ol.426678
• 发表时间: 2021-06-01
• 期刊: OPTICS LETTERS
• 影响因子: 3.6
• 作者: Zhou, Yifeng;Zhong, Fenghe;Hu, Song
• 通讯作者: Hu, Song

High-speed wide-field multi-parametric photoacoustic microscopy.

• DOI: 10.1364/ol.391824
• 发表时间: 2020-05-15
• 期刊: Optics letters
• 影响因子: 3.6
• 作者: Zhong F;Bao Y;Chen R;Zhou Q;Hu S
• 通讯作者: Hu S

Sparse Coding-Enabled Low-Fluence Multi-Parametric Photoacoustic Microscopy.

• DOI: 10.1109/tmi.2021.3124124
• 发表时间: 2022-04
• 期刊: IEEE transactions on medical imaging
• 影响因子: 10.6

Thin-film optical-acoustic combiner enables high-speed wide-field multi-parametric photoacoustic microscopy in reflection mode.

• DOI: 10.1364/ol.475373
• 发表时间: 2023-01
• 期刊: Optics letters
• 影响因子: 3.6
• 作者: Fenghe Zhong;Song Hu