Tubular and Planar Approaches to Separations (TAPAS)

管状和平面分离方法 (TAPAS)

基本信息

批准号：
2003324
负责人：
Purnendu Dasgupta
金额：
$ 51.13万
依托单位：
University of Texas at Arlington
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-12-15 至 2024-11-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2003324&HistoricalAwards=false
关键词：
Tubular Planar Approaches Separations TAPAS

项目摘要

With support from the Chemical Measurement & Imaging (CMI) Program in the Division of Chemistry, Professor Purnendu K. (Sandy) Dasgupta and his students at the University of Texas at Arlington are working to improve the performance and portability of a family of important instruments known as chromatographs. These instruments are widely used for separating the constituents of complex mixtures, enabling further analysis of the separated components. The underlying science of chromatography is critical for applications such as assuring the purity of reagents used in the semiconductor industry; environmental analysis (including monitoring reactive pollutants that cannot survive a long trip to the lab); monitoring water disinfection byproducts; manufacturing pharmaceuticals; and monitoring food safety. The Dasgupta group is working to make such instruments easily field-portable (small, lightweight, low-power, and low-cost) without compromising their separation capabilities. The aim is on-site measurement in such contexts as a physician’s office or patient's bedside; industrial troubleshooting; and water-monitoring in submarines and even in the international space station. Through involvement of students ranging from junior- and senior-level high school interns through postdoctoral fellows, Professor Dasgupta is also addressing the high demand for people trained to use these techniques. As he develops new instruments and techniques, he is incorporating them into laboratory curricula and working with instrument-makers for commercialization.The Dasgupta group is using moldable ion-exchange polymers developed in the previous NSF-funded project to make ion transport-driven nonmechanical nL/min - uL/min pumps and molded microchannels to provide ultra-miniature suppressors and eluent generators. Open-channel columns with helical and 2D/3D serpentine geometries are being systematically investigated for their separations capabilities. These columns can be fabricated by 3D printing and near-IR laser machining, making them inexpensive and amenable to mass production. The team is exploring direct photothermal and multireflection absorption measurements for sensitive detection, as well as computational techniques to reduce dispersion. Finally, they are exploring the use of porous tubes (where radial flow is induced by evaporation) and pressure-driven axial flow in the presence of a transverse, time-dependent, electric field as approaches to achieving the high separation efficiencies characteristic of microchannels while operating at higher flow rates, so that extra-column dispersion requirements are lessened.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在化学系化学测量与成像 (CMI) 项目的支持下，德克萨斯大学阿灵顿分校的 Purnendu K. (Sandy) Dasgupta 教授和他的学生正在努力提高一系列重要仪器的性能和便携性这些仪器被广泛用于分离复杂混合物的成分，从而能够对分离的成分进行进一步分析，而色谱的基础科学对于确保混合物的纯度等应用至关重要。半导体行业中使用的试剂；环境分析（包括监测无法在实验室中长期存在的反应性污染物）；以及监测药品生产过程中的食品安全；便携式（小型、轻量、低功耗和低成本），且不影响其分离能力，目的是在医生办公室或患者床边进行现场测量；达斯古普塔教授还通过从初高中实习生到博士后的学生的参与，解决了对潜艇甚至国际空间站中的水监测的问题。开发新仪器和技术，他正在将它们纳入实验室课程，并与仪器制造商合作实现商业化。Dasgupta 小组正在使用先前 NSF 资助的项目中开发的可模制离子交换聚合物来制造离子传输驱动的 nL/min - uL/min 泵和模制微通道可提供超小型抑制器和洗脱液发生器具有螺旋和 2D/3D 蛇形几何形状的开放通道柱的分离能力正在接受系统研究。通过 3D 打印和近红外激光加工制造，使其价格低廉且适合大规模生产，该团队正在探索直接光热和多重反射吸收。最后，他们正在探索使用多孔管（其中由蒸发引起径向流）和在存在横向、时间相关的压力驱动轴向流。电场作为实现微通道高分离效率特性的方法，同时在较高流速下运行，从而减少柱外分散要求。该奖项是 NSF 的法定使命，并被认为值得通过以下方式支持：使用基金会的智力价值和更广泛的影响审查标准进行评估。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Shape-Based Peak Identity Confirmation in Liquid Chromatography

液相色谱中基于形状的峰同一性确认

DOI：
10.1021/acs.analchem.0c04432
发表时间：
2021-03
期刊：
Analytical Chemistry
影响因子：
7.4
作者：
Kadjo, Akinde F.;Dasgupta, Purnendu K.;Srinivasan, Kannan
通讯作者：
Srinivasan, Kannan

Moldable capillary suppressor for open tubular ion chromatography based on a polymeric ion exchanger.

用于基于聚合物离子交换器的开管离子色谱的可模压毛细管抑制器。

DOI：
10.1016/j.talo.2021.100062
发表时间：
2021-12
期刊：
Talanta Open
影响因子：
0
作者：
Maleki, Fereshteh;Chouhan, Bikash;Shelor, Charles P.;Dasgupta, Purnendu K.
通讯作者：
Dasgupta, Purnendu K.

Automated Programmable Generation of Broad pH Range Volatile Ionic Eluents for Liquid Chromatography

自动可编程生成用于液相色谱的宽 pH 范围挥发性离子洗脱液

DOI：
10.1021/acs.analchem.0c05089
发表时间：
2021-04
期刊：
Analytical Chemistry
影响因子：
7.4
作者：
Shelor, Charles Phillip;Yoshikawa, Kenji;Dasgupta, Purnendu K.
通讯作者：
Dasgupta, Purnendu K.

The Air Quality Index (AQI) in historical and analytical perspective a tutorial review

历史和分析角度的空气质量指数 (AQI) 教程回顾

DOI：
10.1016/j.talanta.2023.125260
发表时间：
2024-01
期刊：
Talanta
影响因子：
6.1
作者：
Horn, Seth A.;Dasgupta, Purnendu K.
通讯作者：
Dasgupta, Purnendu K.

Geometric characterization of polymeric capillaries

聚合物毛细管的几何表征

DOI：
10.1016/j.aca.2022.340345
发表时间：
2022-10
期刊：
Analytica Chimica Acta
影响因子：
6.2
作者：
Yousef, Enas N.;Dasgupta, Purnendu K.;Horn, Seth A.;Shelor, C. Phillip;Roy, Souvik
通讯作者：
Roy, Souvik