Doctoral Dissertation Research: Positioning translational research in the biotech ecosystem: From basic research to more exploitable knowledge

博士论文研究：在生物技术生态系统中定位转化研究：从基础研究到更可利用的知识

基本信息

批准号：
2022218
负责人：
Nicholas Vonortas
金额：
$ 1.14万
依托单位：
George Washington University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2023-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2022218&HistoricalAwards=false
关键词：
Doctoral Dissertation Research Positioning translational

项目摘要

Novel scientific discoveries in the biomedical sector do not become viable clinical treatments or commercial products by themselves. There are numerous steps to go through and obstacles to overcome along the complex biomedical developmental process. Translational research has emerged to increase the speed of the conversion process and improve biomedical productivity. Since 2006, the National Institutes of Health (NIH)’s Clinical and Translational Science Awards (CTSA) program has supported over 60 institutions in order to improve the clinical and translational research environment. While current literature examines the effect of the NIH translational research program, the scope of its analysis is generally restricted to publication at the recipient level. This study analyzes the effect of the NIH CTSA program on biotech entrepreneurship by expanding the scope of analysis to a broader level. In addition, this project attempts to identify the effective combinations of conditions for a high level of biotech entrepreneurship with a specific emphasis on the role of translational research. The results will contribute to a more comprehensive understanding of the effect of translational research in the context of biotech entrepreneurial activity and help us to assess the potential benefit of translational research to the public health. The research draws on the entrepreneurial ecosystem approach and the knowledge spillover theory of entrepreneurship to analyze the effects of translational research on biotech entrepreneurship. The overarching analytical framework is that translational research increases biotech entrepreneurship by increasing the commercially exploitable knowledge stock that is available to entrepreneurs. For the empirical testing, the project uses federal innovation programs such as the Small Business Innovation Research as a proxy for biotech entrepreneurship. This study also considers and examines the biomedical patent, among other forms of exploitable knowledge. The empirical methods highlight how having the translational research program makes differences in the outcomes. Data is collected through various sources including federal agencies such as the National Institutes of Health, the National Science Foundation, and the Census Bureau. The findings will be principally disseminated through publication and will contribute to the literature in the translational research and entrepreneurial ecosystem fields. Additionally, federal agencies like the NIH will have access to a careful empirical appraisal of the CTSA program’s contribution to biomedical enterprises.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物医学领域的新科学发现本身并不能成为可行的临床治疗或商业产品，在复杂的生物医学发展过程中需要经历许多步骤和克服障碍，以提高转化过程的速度和速度。自 2006 年以来，美国国立卫生研究院 (NIH) 的临床和转化科学奖 (CTSA) 计划已支持 60 多个机构，以改善临床和转化研究环境，同时当前的文献也检验了其效果。作为 NIH 转化研究计划的一部分，其分析范围通常仅限于接受者层面的出版物。本研究通过将分析范围扩大到更广泛的层面来确定 NIH CTSA 计划对生物技术创业的影响。高水平生物技术创业的条件的有效组合，特别强调转化研究的作用，结果将有助于更全面地了解转化研究在生物技术创业活动中的效果，并帮助我们评估。潜力该研究利用创业生态系统方法和创业知识溢出理论来分析转化研究对生物技术创业的影响。总体分析框架是转化研究通过增加商业价值来增加生物技术创业。为了进行实证测试，该项目使用联邦创新计划（例如小企业创新研究）作为生物技术创业的代表。本研究还考虑和审查了生物医学专利以及其他形式的可利用知识。实证方法强调了转化研究计划如何对结果产生影响。数据是通过各种来源收集的，包括美国国立卫生研究院、国家科学基金会和人口普查局等联邦机构。通过出版物进行传播，并将为转化研究和创业生态系统领域的文献做出贡献。此外，NIH 等联邦机构将能够对 CTSA 计划对生物医学企业的贡献进行仔细的实证评估。该奖项反映了 NSF 的法定使命，并具有到过通过使用基金会的智力优点和更广泛的影响审查标准进行评估，认为值得支持。