Doctoral Dissertation Research: Positioning translational research in the biotech ecosystem: From basic research to more exploitable knowledge

博士论文研究：在生物技术生态系统中定位转化研究：从基础研究到更可利用的知识

基本信息

批准号：
2022218
负责人：
Nicholas Vonortas
金额：
$ 1.14万
依托单位：
George Washington University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2023-06-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2022218&HistoricalAwards=false
关键词：
Doctoral Dissertation Research Positioning translational

项目摘要

Novel scientific discoveries in the biomedical sector do not become viable clinical treatments or commercial products by themselves. There are numerous steps to go through and obstacles to overcome along the complex biomedical developmental process. Translational research has emerged to increase the speed of the conversion process and improve biomedical productivity. Since 2006, the National Institutes of Health (NIH)’s Clinical and Translational Science Awards (CTSA) program has supported over 60 institutions in order to improve the clinical and translational research environment. While current literature examines the effect of the NIH translational research program, the scope of its analysis is generally restricted to publication at the recipient level. This study analyzes the effect of the NIH CTSA program on biotech entrepreneurship by expanding the scope of analysis to a broader level. In addition, this project attempts to identify the effective combinations of conditions for a high level of biotech entrepreneurship with a specific emphasis on the role of translational research. The results will contribute to a more comprehensive understanding of the effect of translational research in the context of biotech entrepreneurial activity and help us to assess the potential benefit of translational research to the public health. The research draws on the entrepreneurial ecosystem approach and the knowledge spillover theory of entrepreneurship to analyze the effects of translational research on biotech entrepreneurship. The overarching analytical framework is that translational research increases biotech entrepreneurship by increasing the commercially exploitable knowledge stock that is available to entrepreneurs. For the empirical testing, the project uses federal innovation programs such as the Small Business Innovation Research as a proxy for biotech entrepreneurship. This study also considers and examines the biomedical patent, among other forms of exploitable knowledge. The empirical methods highlight how having the translational research program makes differences in the outcomes. Data is collected through various sources including federal agencies such as the National Institutes of Health, the National Science Foundation, and the Census Bureau. The findings will be principally disseminated through publication and will contribute to the literature in the translational research and entrepreneurial ecosystem fields. Additionally, federal agencies like the NIH will have access to a careful empirical appraisal of the CTSA program’s contribution to biomedical enterprises.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物医学部门中的新科学发现本身并不成为可行的临床治疗或商业产品。在复杂的生物医学发育过程中，有许多步骤需要解决，要克服障碍。转化研究已经出现，以提高转化过程的速度并改善生物医学产品。自2006年以来，美国国立卫生研究院（NIH）的临床和转化科学奖（CTSA）计划已支持60多个机构，以改善临床和转化研究环境。尽管当前的文献研究了NIH转化研究计划的效果，但其分析的范围通常仅限于接受者级别的出版物。这项研究通过将分析范围扩大到更广泛的水平来分析NIH CTSA计划对生物技术企业家精神的影响。此外，该项目试图确定高水平的生物技术企业家精神的有效疾病组合，并特别强调转化研究的作用。结果将有助于更全面地了解在生物技术创业活动中转化研究的影响，并帮助我们评估转化研究对公共卫生的潜在好处。该研究借鉴了企业家生态系统方法和企业家知识理论，以分析转化研究对生物技术企业家精神的影响。总体分析框架是翻译研究通过增加企业家可用的商业可利用知识库存来增加生物技术企业家精神。对于经验测试，该项目使用联邦创新计划，例如小型企业创新研究作为生物技术企业家精神的代理。这项研究还考虑并研究了生物医学专利，以及其他形式的可剥削知识。经验方法突出了如何制定翻译研究计划的结果差异。数据通过各种来源收集，包括联邦机构，例如美国国立卫生研究院，国家科学基金会和人口普查局。这些发现将主要通过出版物传播，并将为翻译研究和企业家生态系统领域的文献做出贡献。此外，像NIH这样的联邦机构将对CTSA计划对生物医学企业的贡献进行认真的经验评估。该奖项反映了NSF的法定任务，并被认为是通过基金会的知识分子优点和更广泛的影响审查标准来评估的珍贵支持。