Multiphase Chemo-Fluid Dynamics in the Stomach: Computational Models with Applications to Gastric Digestion in Health and Disease

胃中的多相化学流体动力学：计算模型在健康和疾病中胃消化中的应用

• 批准号: 2019405
• 负责人: Rajat Mittal
• 金额: $ 39.21万
• 依托单位: Johns Hopkins University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2019405&HistoricalAwards=false
• 关键词: Multiphase; Chemo; Fluid; Dynamics; Stomach

Human digestion is a complex process wherein ingested food is broken into nutrients that can be used by the body for growth, cell maintenance, and fuel. The stomach plays a pivotal role in digestion since it receives and stores ingested food, mixes, softens and breaks it down via mechanical and chemical processing, and then undergoes digestion in a regulated manner for absorption. The goal of the current project is to develop a suite of advanced computational tools to model the digestion process in the stomach and to employ these tools to conduct a comprehensive investigation of the coupled chemo-fluid dynamic mechanisms that underlie gastric digestion. Gastric digestion is implicated in some of the most important health issues of our time: nutrition, food borne illnesses, obesity and diabetes mellitus. Together, these illnesses affect hundreds of millions of people around the world and the research conducted here will have direct application to these health conditions. The computational tools developed here will also find use in other arenas of mechanical, chemical and biomedical engineering. Student training will contribute to a cadre of scientists and engineers who are well-equipped to tackle the increasingly cross-disciplinary nature of research and engineering. Outreach to the K-12 community will leverage local connections with the Baltimore high schools, including women and minority serving institutions.The project will develop computational tools that couple multifluid flows with biochemical reactions in dynamically deforming domains as well as first-of-their-kind models for dissolution of solid food particles via chemo-fluid mechanisms. Using these tools, new and important insights into the flow physics that drives gastric digestion in health and disease, will be generated. The physics of gastric digestion is driven by three equally important factors – stomach motility, multifluid/multiphase fluid dynamics, and gastric chemistry and the research project tackles all three of these factors. In particular, the research will answer the following key questions: how does stomach motility determine the mixing, transport, chemical processing and emptying of multi-fluid food mixtures in the stomach? How does the pH-sensitivity of enzymatic activity combine with mixing-induced pH ``microclimates`` to modulate the chemical breakdown of carbohydrate, lipid and protein rich foods in the stomach? How are solid foods processed in the complex chemo-fluid dynamic environment of the stomach and what role do particle-fluid and particle-wall interactions play in this process?This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

人体消化是一个复杂的过程，其中摄入的食物被分解成营养，人体可用于生长，细胞维护和燃料。该摊位在消化中起关键作用，因为它接受并存储食物，混合，软化并通过机械和化学加工来将其分解，然后以受调节的滥用方式进行消化。当前项目的目的是开发一套先进的计算工具，以建模胃中的消化过程，并使用这些工具对胃消化基础的耦合化学化学流体动态机制进行全面研究。胃消化是在我们时代最重要的健康问题中实施的：营养，食物出生疾病，肥胖和糖尿病。这些疾病共同影响了世界各地数亿人，此处进行的研究将直接适用于这些健康状况。这里开发的计算工具还将在其他机械，化学和生物医学工程领域中找到使用。学生培训将为一群科学家和工程师的干部做出贡献，这些科学家和工程师能够应对研究和工程的日益跨学科性质。向K-12社区的推广将利用与巴尔的摩高中（包括妇女和少数派服务机构）的本地联系。该项目将开发计算工具，使多流体流与动态变形域以及通过化学粉料通过化学粉状液体溶解固体粒子的模型中的多流体流与生化反应息息相关。使用这些工具，将产生对驱动健康和疾病胃消化的流动物理学的新的重要见解。胃消化的物理学是由三个同样重要的因素驱动的：失速运动，多液/多相动力学和胃化学，研究项目解决了所有这三个因素。特别是，该研究将回答以下关键问题：林分运动如何决定摊位中多流体食物混合物的混合，运输，化学加工和排空？酶活性的pH敏感性如何与混合诱导的pH``微气候''相结合以调节摊位中碳氢，脂质和富含蛋白质的食物的化学分解？在复杂的化学化学流体动态环境中如何处理固体食品，在此过程中粒子流体和颗粒壁相互作用在什么作用？该奖项反映了NSF的法定任务，并通过使用基金会的智力优点和更广泛的影响标准来评估NSF的法定任务。

项目成果

Effect of stomach motility on food hydrolysis and gastric emptying: Insight from computational models

• DOI: 10.1063/5.0120933
• 发表时间: 2022-11-01
• 期刊: PHYSICS OF FLUIDS
• 影响因子: 4.6
• 作者: Kuhar, Sharun;Lee, Jae Ho;Mittal, Rajat
• 通讯作者: Mittal, Rajat

Computational modeling of drug dissolution in the human stomach: Effects of posture and gastroparesis on drug bioavailability

• DOI: 10.1063/5.0096877
• 发表时间: 2022-08-01
• 期刊: PHYSICS OF FLUIDS
• 影响因子: 4.6
• 作者: Lee, J. H.;Kuhar, S.;Mittal, R.
• 通讯作者: Mittal, R.