MRI: Acquisition of an Operando 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer

MRI：购买 Operando 500 MHz 核磁共振 (NMR) 波谱仪

基本信息

批准号：
2017891
负责人：
Charles Fry
金额：
$ 48.9万
依托单位：
University of Wisconsin-Madison
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-01 至 2023-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=2017891&HistoricalAwards=false
关键词：
MRI Acquisition Operando 500 MHz

项目摘要

This award is supported by the Major Research Instrumentation and the Chemistry Research Instrumentation programs. The University of Wisconsin Madison is acquiring a 500 MHz nuclear magnetic resonance (NMR) spectrometer equipped with a flow tube accessory and dedicated software that enable online monitoring of chemical reactions in real-time under actual experimental conditions. The instrumentation supports Professor Charles Fry and colleagues at the Wisconsin High-Pressure Reactor (WiHP-NNMR). This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as permitting study of biologically relevant species. In general, NMR spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. This instrument is an integral part of teaching as well as research and research training of undergraduate students in chemistry and biochemistry at this institution and nearby colleges such as Madison College, University of Wisconsin La Crosse, University of Wisconsin Rock County, University of Wisconsin Whitewater, Lawrence University, Maranatha Baptist University, Indiana State University and Valparaiso University. The Magnetic Resonance Facility plays an important role in strengthening the relationship between the University and Wisconsin citizens by working closely with departmental programs advocating the importance of science, research, and education to the public.The award of the NMR spectrometer is aimed at enhancing research and education at all levels. It especially impacts discovery of metal-metal bonded catalysts and carbon-hydrogen functionalization reactions. The instrumentation is also for exploring photoredox catalysis, polymer mechanochemistry and three-dimensional (3D) printing. In addition, it provides information on operando investigations of transition metal catalyzed reactions. An operando method involves spectroscopic characterization of materials undergoing reaction which is coupled simultaneously with measurement of catalytic activity and selectivity. The spectrometer is also used to develop catalysts for aerobic oxidation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项得到了主要的研究工具和化学研究工具计划的支持。威斯康星大学麦迪逊分校正在购买配备流管附件和专用软件的500 MHz核磁共振（NMR）光谱仪，可在实际实验条件下实时对化学反应进行在线监测。该仪器支持威斯康星州高压反应堆（WIHP-NNMR）的Charles Fry教授及其同事。该光谱仪允许在各种领域进行研究，例如加速具有重要经济意义的化学反应的领域，并允许研究生物学相关物种。通常，NMR光谱是化学家可用的最强大工具之一，用于阐明分子结构。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液中分子或固态中分子之间相互作用的动力学。对于正在进行边境研究的化学家来说，获得最先进的NMR光谱仪至关重要。该乐器是该机构的化学和生物化学本科生的教学和研究培训的组成部分，以及附近的学院，例如麦迪逊学院，威斯康星大学拉克罗斯大学，威斯康星大学岩石县，威斯康星大学洛克县，威斯康星大学怀特沃特大学，劳伦斯大学，劳伦斯大学，马拉纳塔·巴蒂斯特大学，印第安纳州劳伦斯大学，印第安纳州立大学，瓦拉帕斯特大学和瓦拉帕尔大学。磁共振设施在加强大学和威斯康星州公民之间的关系方面起着重要作用，通过与部门计划紧密合作，主张科学，研究和教育对公众的重要性。NMR光谱仪的奖励旨在增强各级研究和教育。它特别影响了金属金属键合催化剂和碳氢功能化反应的发现。该仪器还用于探索光电毒素催化，聚合物机械化学和三维（3D）打印。此外，它提供了有关过渡金属催化反应的操作研究的信息。操作方法涉及对反应的材料的光谱表征，该反应与催化活性和选择性的测量同时耦合。光谱仪还用于开发有氧氧化的催化剂。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，被认为值得通过评估来获得支持。