PFI-TT: Development of a visual sensor to non-invasively monitor biodegradable magnesium alloy implants for biomedical applications

PFI-TT：开发视觉传感器，以非侵入性方式监测生物医学应用中的可生物降解镁合金植入物

• 批准号: 2016475
• 负责人: Peng Zhang
• 金额: $ 25万
• 依托单位: University of Cincinnati Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-15 至 2024-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2016475&HistoricalAwards=false
• 关键词: PFI; TT; Development; visual; sensor

The broader impact/commercial potential of this Partnerships for Innovation - Technology Translation (PFI-TT) project is to understand the biodegradation of magnesium (Mg) alloys used in medical implants and to provide a needed diagnostic sensor for post-surgery evaluation of patients. Mg alloys are increasingly used in biodegradable implants for repairing broken bones and other medical applications because they dissolve after the bone is healed, leaving only the natural bone components. Almost 30% of metal implants such as stainless steel must be removed later due to complications or the need to accommodate a still-growing child. The beneficial aspect of using Mg alloys is that a second surgery is not needed, significantly reducing costs of care, surgery risk, and patient stress. Partnering with a technology commercialization expert, this PFI-TT project will enable development, testing, and optimization of the proposed sensor prototype to monitor the biodegradation of Mg-containing implants in both a laboratory and animal setting, promote education in innovation and entrepreneurship, and engage undergraduate and high school students into educational and research programs. This sensor has commercial potential because it fulfills the unmet need in this growing market for a simple diagnostic test for biodegradation progress that is easily performed in a doctor’s office.The proposed project aims to develop a sensitive, selective and fast-response hydrogen (H2) sensor in the form of a “Band-Aid” type device for the non-invasive monitoring of biodegradable Mg-containing implants. Commonly available X-ray technology works poorly for Mg alloys, because the density of Mg is so close to that of bone that the Mg implants cannot be easily distinguished from bone by X-ray. Thus, there is a critical need for a method to monitor the biodegradation of Mg alloys. Measurement of the low level of H2 gas from the slowly dissolving Mg permeating through skin for the purpose of monitoring the biodegradation of Mg implants is completely unique. The objective of this application is to optimize the H2 sensor prototype. The central hypothesis is that the H2 sensor will non-invasively cause a color change when exposed to H2 and provide a visual map of H2 levels over an area above the Mg implant. This hypothesis is formulated based on the supporting preliminary data. The underlying rationale is that the researchers will obtain insight into the overall design of the sensor, which is an essential step toward commercialization of the sensor for non-invasive monitoring of biodegradation of Mg-containing implants in patients.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这种创新合作伙伴关系的更广泛的影响/商业潜力 - 技术翻译（PFI-TT）项目是了解用于医疗侵害中使用的镁（MG）合金的生物降解，并为患者的术后评估提供所需的诊断传感器。 MG合金越来越多地用于可生物降解的朝鲜中，用于修复骨折的骨骼和其他医疗应用，因为它们在骨骼被治愈后溶解，仅留下天然骨成分。由于并发症或需要容纳一个仍在增长的孩子，因此几乎30％的金属垂体（例如不锈钢）必须在以后去除。使用MG合金的有益方面是不需要第二次手术，可大大降低护理，手术风险和患者压力的成本。该PFI-TT项目与技术商业化专家合作，将使所提出的传感器原型进行开发，测试和优化，以监测实验室和动物环境中含MG的诱因的生物降解，在创新和企业中促进教育，并在教育和研究课程中吸引不足的学生和高中生。该传感器具有商业潜力，因为它在这个不断增长的市场中满足了对生物降解进度的简单诊断测试的未满足需求，该测试易于在医生的办公室中执行。拟议项目旨在以“生物含量”的监视效果的“频道辅助”设备形式开发一种敏感，选择性和快速响应氢（H2）传感器的形式。通常可用的X射线技术对MG合金效果不佳，因为MG的密度非常接近骨头，以至于MG螺栓杆无法通过X射线轻松地与骨头区分。这是至关重要的，需要一种方法来监测MG合金的生物降解。从皮肤中缓慢溶解的毫克渗透的低水平H2气体的测量是完全独特的。该应用程序的目的是优化H2传感器原型。中心假设是，H2传感器在暴露于H2时会非侵入性地引起颜色变化，并在MG植入物上方的区域上提供H2水平的视觉图。该假设是根据支持初步数据提出的。根本的基本原理是研究人员将深入了解传感器的整体设计，这是对传感器进行商业化的重要一步，用于非侵入性监测对患者的MG造成MG的影响。这奖反映了NSF的立法任务，并通过评估基金会的知识优点和广泛的crietia scritia cribia crietia crietia cribitia cromitia cribitia cromitia cromitia cribitia cromitia cromitia cromitia cromit scritia cromitia cromitia cromitia cromitia cromitia cromitia croperia croperia cripitia croperia croperia croperia均被认为是宝贵的。