SCH: INT: Managing Glaucoma in the Digital Age: A New Tonometer to Connect Patients to their Caregivers

SCH：INT：数字时代的青光眼管理：一种将患者与其护理人员联系起来的新型眼压计

• 批准号: 2014389
• 负责人: Piervincenzo Rizzo
• 金额: $ 110万
• 依托单位: University of Pittsburgh
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2014389&HistoricalAwards=false
• 关键词: SCH; INT; Managing; Glaucoma; Digital

Glaucoma is an age-related disease and the second cause of blindness in the world. The risk of developing glaucoma surges when the intraocular pressure (IOP) increases. The measurement of IOP is the cornerstone of the diagnosis/management of glaucoma because elevated pressure is the only risk factor that can be modified through invasive surgery. However tests for IOP now need to be administered by professional caregivers, and is known to miss changes in pressure due to the natural circadian rhythm and the sporadic surges of IOP. The consequence is that the traditional ways IOP is measured during an office visit miss vital information about daily changes and spikes, and are unable to demonstrate the effect of medication or patients’ compliance to a given therapy. In this project, we propose to develop an off-the-counter home tonometer to perform self-measurements of the intraocular pressure using an engineering principle, the propagation of solitary waves, never explored in ophthalmology. This new tonometer would connect remotely glaucoma patients to their eye-care providers via smartphone and a Web-based App, interfaced with the patients’ electronic health record. The proposed glaucoma assessment tonometer is based on the dynamical interaction between the highly nonlinear solitary waves (HNSWs) propagating within a chain of a few mm particles, embedded in the instrument, and the eye to be evaluated and in point-contact with the tip of the instrument (one end of the chain). The instrument will contain: (1) a trigger to induce the waves; (2) a short chain with an internal sensor to measure the waves; (3) a programmable hardware to link the waves’ features to the IOP; (4) Bluetooth technology to communicate with smartphones; (5) an App to chart the IOP data on the smartphone and to interface with the patient’s EHR for direct access by the eye-care professionals. The team is also committed to educating the youngest through outreach activities, volunteering, or judging at international competitions. Finally, the project results will be presented at international conferences and disseminated through peer-reviewed publications.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

青光眼是一种与年龄有关的疾病，也是世界上失明的第二个原因。当眼内压（IOP）增加时，血光瘤激增的风险增加。 IOP的测量是青光眼诊断/管理的基石，因为升高的压力是可以通过侵入性手术来修改的唯一危险因素。但是，IOP的测试现在需要由专业护理人员进行，并且众所周知，由于自然的昼夜节律和IOP的Spionic Surges，众所周知会错过压力的变化。结果是，在办公室访问期间测量了传统的IOP方法，这错过了有关日常变化和峰值的重要信息，并且无法证明药物或患者遵守给定疗法的影响。在这个项目中，我们建议开发一个现有的家居倾向计，以使用工程原理，固体波的传播，从未在眼科中探索过。这款新的Tonometer将通过智能手机和基于Web的应用程序将远程青光眼患者与患者的电子健康记录相互作用。所提出的青光眼评估动物计基于在几个mm颗粒的链中传播的高度非线性固体波（HNSW）之间的动态相互作用，嵌入了仪器中，并与仪器的尖端进行评估的眼睛（一端）。该仪器将包含：（1）诱导波浪的触发器； （2）一个带有内部传感器的短链来测量波浪； （3）可编程硬件将波浪的功能链接到IOP； （4）与智能手机通信的蓝牙技术； （5）一个应用程序，用于在智能手机上绘制IOP数据，并与患者的EHR进行交互，以直接访问眼科专业人员。该团队还致力于通过外展活动，志愿活动或在国际比赛中进行判断。最后，该项目的结果将在国际会议上提出，并通过同行评审的出版物进行传播。该奖项反映了NSF的法定任务，并使用基金会的知识分子优点和更广泛的影响审查标准，通过评估被认为是珍贵的支持。