IRES Track I: Process Development for Cell and Tissue Biomanufacturing

IRES Track I：细胞和组织生物制造工艺开发

• 批准号: 1952614
• 负责人: Elizabeth Lipke
• 金额: $ 30万
• 依托单位: Auburn University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-01 至 2024-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1952614&HistoricalAwards=false
• 关键词: IRES; Track; Process; Development; Cell

This IRES program provides U.S. students with a collaborative, international bioprocess development and cell and tissue biomanufacturing research experience with a U.S. and German team. Although our nation has made large investments and achieved great progress in identifying biotechnologies that can be used to repair the human body following injury or disease, there is a critical need for engineering expertise to implement these discoveries, bringing them from the lab bench to commercial products. Knowledge and platforms to enable industrial scale cell and tissue biomanufacturing are critical for realizing clinical treatments and maximizing the societal benefits from the long-term research in these fields. Whereas human pluripotent stem cells (hPSCs) can now, in principle, be reliably differentiated into multiple therapeutic cell types, production of sufficient numbers of cells for clinical therapy is not yet typically feasible. Establishing the bioprocessing capabilities required to manufacture cells and tissues for commercial and clinical regenerative applications requires international and interdisciplinary student researcher training. This IRES program engages and trains students in applying their engineering and biological expertise to this problem in a research location, Germany/Hannover Medical School/LEBAO, which is at the forefront in this area. The overall goal is to produce scientists and engineers with strong technical communication and problem-solving skills and who have strong cultural competency and can work effectively with international partners to further our ability to repair the human body.This IRES project establishes an international research and education partnership/program in process development for cell and tissue biomanufacturing between Auburn University (AU) and Hannover Medical School (MHH, Germany). This collaborative international research program will train 15 undergraduate and graduate student researchers over the course of three years in interrelated projects on process development for cell and tissue biomanufacturing at the MHH in Germany. Students are engaged both in an individual research project and in cohesive efforts of the integrated research team. Undergraduate and graduate student researchers are recruited through existing, strong biomanufacturing research ties with Alabama State University, an HBCU, and the AU Engineering’s state-wide network on community colleges, in addition to engaging AU students already working collaboratively with LEBAO faculty. Reflective writing and ePortfolios are used to guide students learning experiences. Students will gain subject expertise and practice technical communication skills through regular individual projects presentations to the IRES student cohort and PI, culminating a research poster presentation for members of the host institute and their local home institutions. Through formation of this diverse team of undergraduate and graduate researchers and their engagement in an international learning and research environment, the program facilitates acquisition of intercultural skills and greater global competency. The objective of this IRES project is to provide students with a high-quality international research experience, increase student retention and diversity, advance students’ knowledge of culture and scientific education and to promote their personal network development and carrier opportunities on a trans-institutional and trans-Atlantic level.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

尽管我们国家在识别可用于修复人体的生物技术方面投入了大量资金并取得了巨大进展，但该 IRES 项目为美国学生提供了与美国和德国团队合作的国际生物工艺开发以及细胞和组织生物制造研究经验。在受伤或患病后，迫切需要工程专业知识来实施这些发现，将其从实验室工作台转化为商业产品。知识和平台以实现工业规模的细胞和组织生物制造对于实现临床治疗和治疗至关重要。尽管人类多能干细胞（hPSC）现在原则上可以可靠地分化为多种治疗细胞类型，但通常还不能生产足够数量的细胞用于临床治疗。建立商业和临床再生应用所需的生物加工能力需要国际和跨学科的学生研究人员培训，并培训学生在研究地点应用他们的工程和生物专业知识，德国/汉诺威医学院/LEBAO，在这一领域处于领先地位，其总体目标是培养具有强大技术沟通和解决问题能力、具有强大文化能力并能够与国际合作伙伴有效合作以进一步发展的科学家和工程师。我们修复人体的能力。该 IRES 项目在奥本大学（AU）和汉诺威医学院（MHH，德国）之间建立了细胞和组织生物制造工艺开发的国际研究和教育合作伙伴关系/计划。火车15 名本科生和研究生研究人员在德国 MHH 进行了三年的细胞和组织生物制造工艺开发相关项目。学生们既参与个人研究项目，也参与综合研究团队的共同努力。研究人员正在通过与阿拉巴马州立大学、HBCU 和 AU Engineering 在社区学院的全州网络现有的强大生物制造研究联系进行招募，此外还吸引已经与 LEBAO 合作的 AU 学生反思性写作和电子档案用于指导学生的学习经验，学生将通过定期向 IRES 学生群体和 PI 进行个人项目演示来获得学科专业知识并练习技术沟通技巧，最终为主办机构及其成员进行研究海报演示。通过组建这个由本科生和研究生研究人员组成的多元化团队，并让他们参与国际学习和研究环境，该项目有助于获得跨文化技能和更大的全球能力。高品质国际化研究经验，增加学生和多样性，提高学生的文化和科学教育知识，并在跨机构和跨大西洋层面促进他们的个人网络发​​展和职业机会。保留该奖项反映了 NSF 的法定使命，并被认为是值得的通过使用基金会的智力优势和更广泛的影响审查标准进行评估来获得支持。