I-Corps: Naturally inspired approach to preserving cellular therapies

I-Corps：保留细胞疗法的自然启发方法

• 批准号: 1951443
• 负责人: Allison Hubel
• 金额: $ 5万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-12-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1951443&HistoricalAwards=false
• 关键词: Corps; Naturally; inspired; approach; preserving

The broader impact/commercial potential of this I-Corps project is to provide a new platform for the cryopreservation of cellular therapies. This technology will allow for improved preservation of cells through the development of cell-type specific cryoprotective solutions and protocols that deliver high survival and function of cells after freezing and thawing. The cell therapy industry is a rapidly growing market that is expected to reach $8.21 billion by 2025. The proposed project will impact the cell therapy industry by improving quality of cells after freezing and thawing, extending the shelf life of these cells from hours or days to months or years, and alleviating processing bottlenecks associated with current preservation methods. This technology can be adapted for a variety of cell types, which may be administered to patients as cell therapies, used for research applications, or stored in biobanks. This I-Corps Teams project builds upon prior research in the development of cryoprotective solutions and protocols for a variety of cell types. The technology utilizes algorithm-driven optimization to create novel, nontoxic cryoprotective solutions inspired by how organisms survive freezing in nature. Proof-of-concept has been demonstrated with a cryoprotective solution and protocol optimized for the preservation of mesenchymal stem cells, which is currently undergoing beta testing at 8 sites. Additional technologies for other cell types are in progress. Development of this technology for specific markets requires a thorough understanding of customer needs. This I-Corps team project is aimed at identifying customer needs through customer discovery interviews, which will inform the development of new products in our pipeline to meet these specific needs.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这个I-Corps项目的更广泛的影响/商业潜力是为细胞疗法的冷冻保存提供一个新的平台。这项技术将通过开发细胞类型的特异性冷冻保护溶液和方案来改善细胞的保存，这些溶液和方案在冷冻和解冻后提供高生存和功能。细胞疗法行业是一个快速增长的市场，预计到2025年将达到82.1亿美元。拟议的项目将通过冻结和融化后的细胞质量来影响细胞治疗行业几个月或几年，并减轻与当前保存方法相关的加工瓶颈。该技术可以适用于多种细胞类型，这些细胞类型可以用作患者作为细胞疗法，用于研究应用，也可以存储在生物库中。 这个I-Corps团队项目基于在开发各种细胞类型的冷冻保护解决方案和协议方面的先前研究。 该技术利用算法驱动的优化来创建受生物体如何在自然界冻结中生存的新颖，无毒的冷冻保护解决方案。概念证明已通过冷冻保护溶液和方案进行了优化，以保存间充质干细胞，该方案目前正在8个地点进行β测试。其他细胞类型的其他技术正在进行中。为特定市场开发这项技术需要彻底了解客户需求。这个I-Corps团队项目旨在通过客户发现访谈来确定客户需求，该访谈将为我们的管道中的新产品开发以满足这些特定需求。该奖项反映了NSF的法定任务，并被认为是值得通过使用的支持。基金会的智力优点和更广泛的影响审查标准。