SBIR Phase II: Presbyopia Correcting Intraocular Lens with a Novel Refractive System for Restoration of a Complete Range of Vision and Spectacle Independence

SBIR 第二阶段：采用新型屈光系统的老花眼矫正人工晶状体，可恢复完整的视力范围和眼镜独立性

• 批准号: 1951259
• 负责人: Kevin Harris
• 金额: $ 75万
• 依托单位: CLEARSIGHT, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1951259&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Presbyopia; Correcting

The broader/commercial impact of this SBIR Phase II project aims to address two common conditions in the aging population, presbyopia and cataract, with a single device. Presbyopia, the age dependent loss in the ability of the eye to adjust focus, is expected to affect an estimated 1.4 billion people worldwide by 2020. Cataract, the irreversible clouding of the lens that results in blurred vision and the leading cause of blindness in the world, is expected to affect an estimated 30 million Americans by 2020. Currently no single product restores both visual clarity and a complete range of spectacle-free vision following cataract surgery. The proposed device will change the standard of care for cataract surgery, leading to improved outcomes.This SBIR Phase II project will develop an intraocular lens using a new, highly sensitive optical system that leverages large differences in refractive indices and has a novel mechanism of action, potentially leading to levels of accommodation on par with the abilities of a young, pre-presbyopic individual. Prospective technologies may fail to exhibit adequate accommodative amplitude to restore a full range of vision, produce unwanted visual artifacts, or are too complex for adoption at scale. Using highly sensitive optics, the proposed device mimics the shape of the natural lens while still maintaining relative simplicity, allowing for maximum utilization of the minute forces in the eye to produce significant accommodation and permitting the use of standard cataract surgical procedures. This technical tasks associated with the new intraocular lens include: (1) assuring visual quality through the device’s accommodative range, (2) optimizing mechanics for restoration of a complete range of vision, (3) integrating seamlessly with existing surgical procedures, and (4) testing implant longevity and safety. Validating the objectives above through optical and mechanical testing in benchtop, cadaver, and animal models will provide a strong foundation for clinical investigations and translation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

更广泛的/委员会II项目的目的是通过一种设备来解决老龄化人口的两个常见条件。 . The IRREVERSIBLE CLOUDING OF THAT RESULTS IN BLURRED VISION AND TOEADING Cause of Blindness in the World, is expected to an Estimated 30 Million Americans by 2020. Currently NO SINGLE Product Restors Both Visual Clarity and A Composition-Free Vision Vision Following Cataract Surgery. The提议的设备是对Ataract手术的护理标准，从而改善了结果。该SBIR II期项目与使用新的，高度敏感的光学系统开发了眼内镜头，该镜头在折射率上有很大的差异，并且具有新颖的作用机理在动作上的机理与年轻的，前瞻性技术的能力相提并论，可以恢复全方位的视力，或者对收养而言太复杂了。在产生明显的和标准性白内障手术程序的重要性中。和安全性。标准。