SBIR Phase II: Microwave ablation system for creating precision directed ablation zones

SBIR 第二阶段：用于创建精确定向消融区域的微波消融系统

基本信息

批准号：
1951186
负责人：
Austin Pfannenstiel
金额：
$ 74.96万
依托单位：
Precision Microwave Inc.
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2020
资助国家：
美国
起止时间：
2020-05-01 至 2023-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1951186&HistoricalAwards=false
关键词：
SBIR Phase II Microwave ablation

项目摘要

The broader/commercial impact of this SBIR Phase II project proposes continued development of a directional microwave ablation (MWA) system. During MWA, doctors use image guidance to insert a thin needle-like applicator into a target tumor and then energize the microwave antenna embedded in the applicator’s tip to heat and kill the tumor. MWA is especially important to the large population of cancer patients who are poor candidates for surgery or other physically demanding therapies, such as chemotherapy or radiation therapy, due to tumor location or poor health. All currently available MWA systems are only capable of producing a roughly spherical or teardrop-shaped treatment zone centered on the axis of the applicator, which is not suitable for treating tumors located near critical anatomy or irregularly shaped targets. This limitation often leaves doctors with a difficult choice of risking undertreatment and disease recurrence or risking overtreatment and damage to critical healthy anatomy that may cause pain or life-threatening complications. Directional MWA would allow the physician to instead place the applicator alongside the tumor and direct heat toward the target and away from nearby sensitive tissues. New clinical techniques enabled by directional MWA could facilitate faster, safer, more effective, and lower cost treatment of localized tumors, and potentially broaden the range of diseases that could be treated in a minimally invasive manner.As microwave antennas typically require physically large structures to achieve a high degree of directivity, developing a small diameter (2.0 mm) applicator suitable for minimally invasive treatments is technically challenging and requires the use of novel design methods, fabrication processes, and materials. Technical work in this Phase II projects includes: 1) Industrialized design of the prototype ablation applicator and transmission cable hub, and associated fabrication and assembly process development to improve quality and clinical usability; 2) Testing and characterization of clinical delivery parameters, and developing an algorithm that informs treatment planning for the creation of customizable treatment zones; 3) Development of a programmable multi-channel MW generator platform, affording customizable control of energy delivery parameters, and 4) Detailed system integration and in vivo system performance assessment and characterization to develop treatment planning and dosing guidelines. We will employ an approach integrating multiphysics computational models, benchtop experimentation in ex vivo tissue, and in vivo experiments in porcine liver and kidney to design, optimize, and validate our applicators and integrated microwave ablation system. The goal of this R&D effort is to complete the technical design of a clinically viable directional microwave ablation system.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

SBIR II期的更广泛/委托提出了定向微波炉的持续开发，医生使用图像图像指导将类似针的涂抹器插入肿瘤和thumor，然后将嵌入在涂抹器的小额杀死的微波天线中肿瘤。某些饲养的CATOR在批判性解剖结构附近弯曲肿瘤，或者不规则地选择了危险的选择不足的危险。，更有效和较低的藻类肿瘤的成本，并有可能以微创的方式扩大处理的范围。作为高定向性的物理上大型结构，开发了适用于最小化技术在技术上的小直径（2.0 mm）的涂抹器Challenining和Recretiles不使用VEL设计方法，制造过程和材料。1）原型和传输电缆集线器的工业化设计用于改进和临床。为了创建可自定义的处理区域； 3）开发可编程的多渠道MW发电机平台，可自定义的能量涂装参数，4）详细的系统集成和体内的系统性能评估和表征。多物理学计算模型，在体内组织VER和肾脏中的台式实验，以设计，优化和验证我们的施用者和集成的微波炉消融系统。并使用基金会的知识分子和更广泛的影响标准通过评估来吸引值得一提的。