CAREER: Palladium or Gold Catalyzed Decarboxylative Functionalization of (Hetero)Arenes

职业：钯或金催化（杂）芳烃的脱羧功能化

• 批准号: 1942223
• 负责人: Thomas Hoye
• 金额: $ 52万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-05-01 至 2022-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1942223&HistoricalAwards=false
• 关键词: CAREER; Palladium; Gold; Catalyzed; Decarboxylative

With this Award, the Chemical Synthesis Program of the NSF Division of Chemistry is supporting the research of Professor Joseph J. Topczewski of the University of Minnesota-Twin Cities. This research project is focusing on developing more efficient methods for organic synthesis. In this research, traditional starting materials are replaced with readily available, lower energy, safer, and less toxic carboxylic acids. These new synthetic methods are replacing prior reactions used in the synthesis of medicines, agrochemicals, and organic electronics. The broader impacts of this work include revitalizing and transforming undergraduate organic chemistry courses and bring a focus on advanced manufacturing method for the chemical industry. Furthermore, undergraduate students, graduate students, and faculty are engaging the citizens of Minnesota through their Market Science program, which brings science fair-like demonstrations to local farmers’ markets.Professor Topczewski and his students are developing new synthetic methods for the decarboxylative cross-coupling and functionalization of (hetero)aryl carboxylic acids. This research focuses on the mechanistic elucidation of the reaction cycle, optimization of the ligand and metal complexes, expansion of the substrate scope, and the development of a broader array of functionalization reactions. Several metal complexes and mechanisms of decarboxylative coupling are being investigated. The broader impacts of this work include recruiting a diverse cohort of scientists to be trained as next generation leaders in the chemical community and promoting outreach through Market Science.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

通过这一奖项，NSF化学部的化学合成计划支持明尼苏达大学 - 两国城市的Joseph J. Topczewski教授的研究，传统的起始材料被替换为替代药物合成和有机电子的先前反应，并替换了有机化的羧酸。行业。这项研究重点阐明了配体和TAL复合物的重新取力，研究了更广泛的功能化反应的发展。通过市场科学来促进社区，并使用基金会的知识分子和更广泛的影响标准进行宣传。

项目成果

Gold Catalyzed Decarboxylative Cross-Coupling of Iodoarenes

• DOI: 10.1021/jacs.0c06244
• 发表时间: 2020-07-29
• 期刊: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
• 影响因子: 15
• 作者: Daley, Ryan A.;Morrenzin, Aaron S.;Topczewski, Joseph J.
• 通讯作者: Topczewski, Joseph J.

Mechanistic Investigation into the Gold-Catalyzed Decarboxylative Cross-Coupling of Iodoarenes

• DOI: 10.1021/acscatal.1c01631
• 发表时间: 2021-07-16
• 期刊: ACS CATALYSIS
• 影响因子: 12.9
• 作者: Daley, Ryan A.;Morrenzin, Aaron S.;Topczewski, Joseph J.
• 通讯作者: Topczewski, Joseph J.

Combined Experimental and Computational Mechanistic Investigation of the Palladium-Catalyzed Decarboxylative Cross-Coupling of Sodium Benzoates with Chloroarenes

• DOI: 10.1021/acs.joc.1c00910
• 发表时间: 2021-08-02
• 期刊: JOURNAL OF ORGANIC CHEMISTRY
• 影响因子: 3.6
• 作者: Humke, Jenna N.;Daley, Ryan A.;Topczewski, Joseph J.
• 通讯作者: Topczewski, Joseph J.