SBIR Phase I: Large Scale Synthesis of Hollow Metal Nanospheres: Conversion of Batch Synthesis to Continuous Flow

SBIR 第一阶段：空心金属纳米球的大规模合成：间歇合成向连续流动的转化

• 批准号: 1940608
• 负责人: Sarah Lindley
• 金额: $ 22.5万
• 依托单位: CORELESS TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-10-15 至 2021-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1940608&HistoricalAwards=false
• 关键词: SBIR; Phase; Large; Scale; Synthesis

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is rooted in the development of a large-scale synthesis for the manufacture of highly uniform hollow metal nanospheres for use by the military in potentially contaminated zones of operation, in rural settings with limited access to healthcare laboratories, or in the agricultural field for faster and more affordable detection of lower levels of food-based toxins and pathogens. Furthermore, establishing a source of these next-generation metal nanoparticles at commercially relevant levels of quality and quantity with consistent and predictable performance would pave the way for their expansion into other industries that could also benefit from their advantages, such as photocatalysis, water purification, and photomedicine.This Small Business Innovation Research (SBIR) Phase I project will scale-up the production of hollow metal nanoparticles from the existing small-batch syntheses to a large-scale continuous flow process, with strict standards for the control of their size, shape, and optical response. Large-scale synthesis of highly uniform hollow metal nanospheres with controllable size has not been achieved to date, hampering the use and study of these advanced materials. A high-quality, high-volume production method will position hollow metal nanospheres for rapid commercial adoption in applications where they markedly outperform their solid counterparts, such as in color reporting for lateral flow assays (LFAs), where hollow gold nanospheres can offer a 10-fold improvement in assay sensitivity. The primary objective of the proposed work is to determine the parameters necessary for a high-quality, high-throughput synthesis based on continuous flow, including reactor materials, chamber dimensions, precursor concentrations, flow rates, and reaction times. The major technical hurdle lies in the identification (within a very large parameter space) of suitable conditions for a successful and controlled synthesis; accordingly, a major component of this project is in-depth analysis and characterization of synthesized nanoparticles by optical spectroscopy and electron microscopy. Characterization results will be used to inform iterative reactor improvements. The resulting high throughput reactor will both advance the state of the art of nanomaterial synthesis and enable new research by creating a consistent supply of commercially available hollow nanoparticles with reproducible physical properties.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）I期项目的更广泛的影响/商业潜力植根于开发大规模合成，用于制造高度均匀的空心金属纳米球，用于在潜在污染的运营区域中使用，在农村地区的潜在污染区域中，在农村环境中，可以在农村环境中使用较低的水平，以较低的水平和较低的水平来实现较低的水平，并以较低的水平和更高的养殖场所和更高的水平。 Furthermore, establishing a source of these next-generation metal nanoparticles at commercially relevant levels of quality and quantity with consistent and predictable performance would pave the way for their expansion into other industries that could also benefit from their advantages, such as photocatalysis, water purification, and photomedicine.This Small Business Innovation Research (SBIR) Phase I project will scale-up the production of hollow metal nanoparticles from the existing small-batch合成到大规模连续流动过程，具有严格的标准，以控制其大小，形状和光学响应。迄今为止尚未实现高度均匀的空心金属纳米球的大规模合成，从而阻碍了这些晚期材料的使用和研究。高质量的高体积生产方法将使空心金属纳米球置于快速商业采用的应用中，在这些应用中，它们明显胜过其固体对应物，例如，在侧向流量测定的彩色报告中，中空金纳米球可以提供10倍的敏感性提高。 拟议工作的主要目的是确定基于连续流的高质量，高通量合成所需的参数，包括反应堆材料，腔室尺寸，前体浓度，流速和反应时间。主要的技术障碍在于成功和受控合成的适当条件的识别（在很大的参数空间内）；因此，该项目的主要组成部分是通过光谱和电子显微镜对合成纳米颗粒的深入分析和表征。表征结果将用于告知迭代反应堆改进。由此产生的高吞吐量反应堆既可以推进纳米材料合成的艺术状态，又可以通过创建具有可重复性物理特性的市售空心纳米颗粒的一致供应来实现新的研究。该奖项反映了NSF的法定任务，并通过使用该基金会的知识优点和广泛影响来评估NSF的法定任务。