Collaborative Research: NCS-FO Biology and Function of Prosody: Integrative approach to individual differences

合作研究：NCS-FO 生物学和韵律功能：个体差异的综合方法

• 批准号: 1926794
• 负责人: Reyna Gordon
• 金额: $ 60.66万
• 依托单位: Vanderbilt University Medical Center
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-10-01 至 2024-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1926794&HistoricalAwards=false
• 关键词: Collaborative; Research; NCS; FO; Biology

College readiness and career opportunities are highly dependent on young adults' reading proficiency. Yet, recent data indicate that almost two-thirds of tested students, including many students with dyslexia, do not possess the fundamental skills that are required to successfully master college-level reading material. Prosody, defined as linguistically relevant fluctuations in intonation, stress and timing, is an essential but underappreciated aspect of spoken language and reading. Humans vary in their sensitivity to the prosodic structure of speech, and there appears to be a strong link to individual differences in reading skills. With the support of the Integrative Strategies in Neural and Cognitive Systems program, this project will take bold steps towards investigating the biology and function of prosody with a creative array of approaches and research settings. With the first-ever dataset of its kind, the project intends to make critical progress towards integrating knowledge from a large population sample about the neurobiological basis of prosody across methods and levels (genetics, neuroimaging, and behavioral task performance). Beyond scientific advancement, the activities outlined in the proposed project will allow the research team to contribute to improving STEM education and educator development, addressing neurodevelopmental disorders such as dyslexia, increasing public engagement with science and technology, and enhancing big-data partnerships across academic sites.The underlying biology of prosody is poorly understood at the neural and genetic level, despite its important function in humans' communication skills. Innovative combinations of multi-disciplinary approaches for novel data collection in large samples and use of existing large-scale resources are needed to yield significant knowledge of the biology and function of prosody. The first aim of this proposal will include a series of studies using a combination of EEG, eye tracking and standardized behavioral tasks to explore the time-dynamic processes of attending to prosodic cues in ecologically valid situations of speech perception and reading, and to examine the contribution of prosody sensitivity to individual differences in reading. The second aim will be a genome-wide association study of prosodic sensitivity and will be conducted through a diverse sample of individuals recruited online throughout the United States and in-person in the Middle Tennessee area in local community and educational settings. Cutting-edge genomic methodologies (PrediXcan and Gene Set Enrichment analysis) will be used to identify the genetic markers and novel neural endophenotypes (imputed gene expression in brain tissue) that give rise to individual differences in prosody. This series of studies builds essential groundwork for future planned studies that seek to disentangle shared versus separate genetic architecture of prosody and other aspects of language function and could reveal transformative knowledge about the biological mechanisms driving individual differences in reading and language skill. The collaborative research project leverages the team?s diverse backgrounds in Cognitive Neuroscience, Psycholinguistics, Communication Disorders, and Human Genetics.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

大学准备和职业机会高度取决于年轻人的阅读能力。但是，最近的数据表明，几乎三分之二的经过测试的学生，包括许多阅读障碍的学生，都不具备成功掌握大学级阅读材料所需的基本技能。韵律被定义为语调，压力和时机上与语言相关的波动，是口语和阅读的必不可少但不足的方面。人类对言语的韵律结构的敏感性各不相同，并且似乎与阅读技能的个体差异有着密切的联系。在神经和认知系统计划中的综合策略的支持下，该项目将采取大胆的步骤来研究韵律的生物学和功能。借助此类数据集的第一个数据集，该项目旨在从大量人群样本中整合有关跨方法和水平的韵律基础的知识的关键进展（遗传学，神经影像学和行为任务绩效）。除了科学进步之外，提议的项目中概述的活动将使研究团队能够为改善STEM教育和教育工作者的发展做出贡献，解决诸如阅读障碍之类的神经发育障碍，增加对科学和技术的公众参与，并增强大型DATA伙伴关系的促进性跨学术伙伴关系。尽管如此，在跨学术范围内，挑剔的生物学知识是在跨越阶段的跨性别范围，并且在层面上具有良好的范围。需要在大型样本中进行新型数据收集的多学科方法的创新组合，并需要使用现有的大规模资源，以产生有关韵律的生物学和功能的重要知识。该提案的第一个目的将包括一系列研究，结合了脑电图，眼科跟踪和标准化的行为任务，以探索在语音感知和阅读的生态有效情况下，参与韵律提示的时间动力学过程，并检查韵律对阅读中个人差异的贡献。第二个目的是全基因组的韵律敏感性研究，并将通过在美国各地在线招募的各种个人以及田纳西州中部的当地社区和教育环境中的个人进行。尖端的基因组方法（预胞素和基因集富集分析）将用于识别遗传标记和新型神经内表型（脑组织中的基因表达），从而导致韵律中个体差异。这一系列研究为未来计划的研究建立了基本的基础，这些研究试图分解共享的韵律和语言功能的其他方面的单独遗传结构，并可以揭示有关促进阅读和语言技能中个体差异的生物学机制的变革性知识。该协作研究项目利用了团队在认知神经科学，心理语言学，沟通障碍和人类遗传学方面的多样背景。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的影响审查标准通过评估来进行评估的。

项目成果

Mental health and music engagement: review, framework, and guidelines for future studies.

• DOI: 10.1038/s41398-021-01483-8
• 发表时间: 2021-06-22
• 期刊: Translational psychiatry
• 影响因子: 6.8
• 作者: Gustavson DE;Coleman PL;Iversen JR;Maes HH;Gordon RL;Lense MD
• 通讯作者: Lense MD

Linking the genomic signatures of human beat synchronization and learned song in birds

将人类节拍同步的基因组特征与鸟类学习的歌曲联系起来

• DOI: 10.1098/rstb.2020.0329
• 发表时间: 2021
• 期刊: Philosophical Transactions of the Royal Society B: Biological Sciences
• 作者: Gordon, Reyna L.;Ravignani, Andrea;Hyland Bruno, Julia;Robinson, Cristina M.;Scartozzi, Alyssa;Embalabala, Rebecca;Niarchou, Maria;Cox, Nancy J.;Creanza, Nicole
• 通讯作者: Creanza, Nicole

The Musical Abilities, Pleiotropy, Language, and Environment (MAPLE) Framework for Understanding Musicality-Language Links Across the Lifespan.

• DOI: 10.1162/nol_a_00079
• 发表时间: 2022
• 期刊: NEUROBIOLOGY OF LANGUAGE
• 影响因子: 3.2
• 作者: Nayak, Srishti;Coleman, Peyton L.;Ladanyi, Eniko;Nitin, Rachana;Gustavson, Daniel E.;Fisher, Simon E.;Magne, Cyrille L.;Gordon, Reyna L.
• 通讯作者: Gordon, Reyna L.

A neurodevelopmental disorders perspective into music, social attention, and social bonding.

• DOI: 10.1017/s0140525x20001302
• 发表时间: 2021-09-30
• 期刊: BEHAVIORAL AND BRAIN SCIENCES
• 影响因子: 29.3
• 作者: Kasdan, Anna;Gordon, Reyna L.;Lense, Miriam D.
• 通讯作者: Lense, Miriam D.

Is atypical rhythm a risk factor for developmental speech and language disorders?

• DOI: 10.1002/wcs.1528
• 发表时间: 2020-04-03
• 期刊: WILEY INTERDISCIPLINARY REVIEWS-COGNITIVE SCIENCE
• 影响因子: 3.9
• 作者: Ladanyi, Eniko;Persici, Valentina;Gordon, Reyna L.
• 通讯作者: Gordon, Reyna L.