I-Corps: Minimizing the risk of radiation to prostate cancer patients

I-Corps：最大限度地降低前列腺癌患者的辐射风险

• 批准号: 1916364
• 负责人: Mohammad Elahinia
• 金额: $ 5万
• 依托单位: University of Toledo
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-03-15 至 2020-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1916364&HistoricalAwards=false
• 关键词: Corps; Minimizing; risk; radiation; prostate

The broader impact/commercial potential of this I-Corps project is by improving the quality of life of prostate and potentially other pelvic cancer patients who receive radiation therapy (RT). Followed by skin cancer, prostate cancer is the most common cancer in American men. The American Cancer Society's estimate for prostate cancer in the United States for 2018 was 164,690 new cases. Most of these cases will receive radiotherapy as part of their treatment. The new trend in RT is to deliver a much higher dose of radiation per fraction in a smaller number of fractions while reducing the required number of RT sessions. However, during RT of the prostate, the rectum acts as a limiting factor. Due to the proximity of rectum to prostate, increasing dosage of the radiation can affect the rectal wall and increase risk of cancer in rectum. The device developed here allows for the expedited treatment plans while eliminating the undesirable damage to the rectal tissue. This can greatly improve a patient's quality of life after completion of radiation treatment. The use of our device reduces the overall required time for the radiation therapy of prostate cancer and saves money for health care providers, health insurances, and patients.This I-Corps project leverages the functionality of nickel titanium to retract the rectum away from the prostate during radiation beam therapy of prostate cancer. This will be a minimally invasive device that uses the biomimetic actuation of the material to create distance between rectum and prostate. NiTi as a biocompatible shape memory alloy is an ideal candidate for biomimetic and biocompatible devices. A control systems design is combined with thermomechanical functionality of the alloy to generate the desired range of motion and profile of force. The actuation takes place by passing a small electrical current in a reliable, clean, and silent manner. This type of actuation is potentially inherently safer when compared to most other means of actuation, because it has a limited range of motion beyond which applying more electrical current does not create further motion.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该I-Corps项目的更广泛的影响/商业潜力是改善接受放射疗法（RT）的前列腺和其他潜在的骨盆癌患者的生活质量。其次是皮肤癌，前列腺癌是美国男性最常见的癌症。美国癌症协会对2018年美国前列腺癌​​的估计为164,690例新病例。这些病例中的大多数将接受放射疗法作为治疗的一部分。 RT的新趋势是在较小数量的分数中提供更高剂量的辐射剂量，同时减少所需数量的RT会话。但是，在前列腺的RT期间，直肠起着限制因素。由于直肠与前列腺的接近度，辐射的剂量增加会影响直肠壁并增加直肠癌的风险。此处开发的设备允许加快治疗计划，同时消除了直肠组织的不良损害。 在辐射治疗完成后，这可以大大改善患者的生活质量。我们的设备的使用减少了前列腺癌的放射治疗的总体所需时间，并为医疗保健提供者，健康保险和患者节省了资金。该I-Corps项目利用了镍钛的功能，可以使直肠从前列腺疗法的辐射疗法治疗前列腺癌期间从前列腺中缩回前列腺。这将是一种最小的侵入性装置，它使用材料的仿生致动物在直肠和前列腺之间创建距离。 NITI作为生物相容性形状的记忆合金是仿生和生物相容性装置的理想候选者。控制系统设计与合金的热机械功能相结合，以生成所需的运动范围和力谱。驱动是通过以可靠，清洁和沉默的方式传递小型电流来进行的。与大多数其他致动手段相比，这种驱动可能会固有地更加安全，因为它的运动范围有限，超出该动作，应用更多的电流并不能产生进一步的动作。该奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的审查标准通过评估来通过评估来支持的。