I-Corps: 6Sensing: Chip-scale Raman sensors

I-Corps：6Sensing：芯片级拉曼传感器

• 批准号: 1851293
• 负责人: Juejun Hu
• 金额: $ 5万
• 依托单位: Massachusetts Institute of Technology
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-11-15 至 2020-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1851293&HistoricalAwards=false
• 关键词: Corps; 6Sensing; Chip; scale; Raman

The broader impact/commercial potential of this I-Corps project is to provide on-chip optical sensors that enable faster and cheaper production of drugs and chemicals. Pharmaceutical R&D and production rely heavily on chemical analysis to provide insight into the processes at play, however analytical instruments do not follow the latest manufacturing trends towards single-use technologies and smaller batches, or even continuous production. Integrated (on-chip) photonics is an attractive sensing platform thanks to its small form factor, robustness, large multiplexing capability, and tight optical confinement that enhances light-matter interactions. This project will pioneer the large-scale use of integrated photonic sensors starting with chemical sensing, paving the way to other applications. By enabling a better understanding of the reactions at play in manufacturing processes, the proposed technology is poised to impact the pharmaceutical market and help improving public health.This I-Corps project aims to develop the first practical implementation of a microchip-scale optical spectrometer. Integrated photonic product remain scarce due to several barriers at the fabrication and packaging levels. This project will mitigate these issues to offer equivalent sensitivity and performance to large benchtop optical spectrometers in a dramatically smaller form factor. This will be realized by combining recent advances in integrated photonic component design, photonic chip architecture, and optical packaging. The proposed sensor will enable novel chemical sensing applications and help with the understanding of processes at play in areas such as cell-based manufacturing and continuous-flow chemical manufacturing.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目更广泛的影响/商业潜力是提供片上光学传感器，能够更快、更便宜地生产药物和化学品。药品研发和生产严重依赖化学分析来深入了解生产过程，但分析仪器并未遵循一次性技术和小批量甚至连续生产的最新制造趋势。集成（片上）光子学因其外形小巧、坚固耐用、复用能力强以及可增强光与物质相互作用的严格光学限制而成为一种有吸引力的传感平台。该项目将率先大规模使用集成光子传感器，从化学传感开始，为其他应用铺平道路。通过更好地了解制造过程中发生的反应，所提出的技术有望影响制药市场并帮助改善公众健康。该 I-Corps 项目旨在开发第一个实际应用的微芯片级光学光谱仪。由于制造和封装层面的一些障碍，集成光子产品仍然稀缺。该项目将缓解这些问题，以更小的外形尺寸提供与大型台式光学光谱仪同等的灵敏度和性能。这将通过结合集成光子元件设计、光子芯片架构和光学封装方面的最新进展来实现。所提出的传感器将实现新颖的化学传感应用，并有助于理解基于细胞的制造和连续流动化学制造等领域中起作用的过程。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准。