I-Corps: Advanced Ultrasonic Imaging for Medical and Non-Destructive Testing Applications

I-Corps：用于医疗和无损检测应用的先进超声波成像

• 批准号: 1906883
• 负责人: Jeroen Tromp
• 金额: $ 5万
• 依托单位: Princeton University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-12-01 至 2022-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1906883&HistoricalAwards=false
• 关键词: Corps; Advanced; Ultrasonic; Imaging; Medical

The broader impact/commercial potential of this I-Corps project is the development of a next-generation, high-resolution ultrasonic imaging technique for medical and non-destructive testing applications. This technique will improve on existing imaging technologies by enabling highly detailed physical and spatial properties of the imaged material to be determined, beyond what is currently capable from ultrasound, X-Rays or MRI. This will enhance the capability of medical and non-destructive imaging technologies, for example, by allowing more accurate identification and diagnoses of tumor tissues in medical scans, or improving the identification of defects in manufactured parts. Combined with the benefits of ultrasound, in particular, safety, speed, portability, patient comfort, and cost, this technology has potential for broad impact. Commercially, the technology will enable medical practitioners to make diagnoses faster and with higher accuracy. This will allow earlier and more precise identification of tumors, reducing the number of false positives and follow-up procedures. This will ultimately increase diagnostic efficiency, reduce costs and improve patient outcomes. In a non-destructive testing application, this technology will enable imaging detail that was previously only available with more expensive and time-consuming techniques such as X-Rays.This I-Corps project combines techniques from the fields of ultrasonic imaging and the geosciences to significantly improve existing mm- to cm-scale imaging technologies. The technology adapts an advanced geophysical imaging method known as full waveform inversion (FWI) for medical and non-destructive testing purposes. Full waveform inversion is conventionally applied for imaging the earth?s structure and to discover oil and gas reservoirs. Instead of applying the technique at seismic scales (m to km), the company applies it at the ultrasonic scale (mm to cm) to generate high-resolution 3-dimensional images with embedded physical properties. Research is focused on both software and hardware development. Software algorithms are being developed which construct images from ultrasonic measurements within seconds to minutes. This is enabled through the use of cutting-edge, highly efficient algorithms and high-performance computing infrastructure. Research and development of prototype hardware is also being undertaken, necessary for generating high-quality ultrasonic data for input into the imaging algorithms. To-date, rapid, high-resolution 2- and 3-dimensional image construction using full waveform inversion techniques has been demonstrated on a range of ?synthetic? ultrasonic-scale objects. This demonstrates that images can be quickly generated, containing a full range of material properties including material density, stiffness and attenuation.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该 I-Corps 项目更广泛的影响/商业潜力是开发用于医疗和无损检测应用的下一代高分辨率超声成像技术。该技术将改进现有的成像技术，能够确定成像材料的高度详细的物理和空间特性，超出了目前超声波、X 射线或 MRI 的能力。这将增强医学和无损成像技术的能力，例如，通过在医学扫描中更准确地识别和诊断肿瘤组织，或改进对制造零件中的缺陷的识别。结合超声波的优点，特别是安全性、速度、便携性、患者舒适度和成本，该技术具有广泛影响的潜力。在商业上，该技术将使医生能够更快、更准确地做出诊断。这将能够更早、更准确地识别肿瘤，减少误报和后续程序的数量。这最终将提高诊断效率、降低成本并改善患者的治疗效果。在无损检测应用中，该技术将实现以前只能通过 X 射线等更昂贵和耗时的技术才能获得的成像细节。这个 I-Corps 项目结合了超声波成像和地球科学领域的技术，显着改进现有的毫米级到厘米级成像技术。该技术采用了一种先进的地球物理成像方法，称为全波形反演（FWI），用于医疗和无损检测目的。全波形反演通常用于地球结构成像和发现油气藏。该公司没有在地震尺度（米到公里）上应用该技术，而是在超声波尺度（毫米到厘米）上应用该技术，以生成具有嵌入式物理特性的高分辨率 3 维图像。研究重点是软件和硬件开发。正在开发的软件算法可以在几秒到几分钟内根据超声波测量构建图像。这是通过使用尖端、高效的算法和高性能计算基础设施来实现的。原型硬件的研究和开发也正在进行中，这是生成高质量超声数据以输入成像算法所必需的。迄今为止，使用全波形反演技术的快速、高分辨率的 2 维和 3 维图像构建已经在一系列“合成”上得到了证明。超声波尺度的物体。这表明可以快速生成图像，包含全方位的材料特性，包括材料密度、刚度和衰减。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优点和更广泛的影响审查标准进行评估，被认为值得支持。