Knifeless Limb Lengthening: Critical Advancement of an Innovative Therapy

无刀肢体延长：创新疗法的关键进展

基本信息

批准号：
10899204
负责人：
Matthew A Halanski
金额：
$ 18.07万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-15 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10899204
关键词：
Ablation Acceleration Advanced Development Anatomy Biomedical Engineering Bone Growth Bone Surface Brain Cardiac Child Child Care Childhood Clinical Complication Data Deformity Detection Dose Drug Targeting Ensure Evaluation Excision Fiber Focused Ultrasound Fracture Goals Growth Growth Disorders Hospitalization Individual Injury Innovative Therapy Kidney Limb structure Liver Malignant neoplasm of liver Measurement Measures Mediating Methods Microscopic Modality Molecular Analysis Molecular Biology Morbidity - disease rate Musculoskeletal Nerve Nerve Crush Nerve Fibers Operative Surgical Procedures Orthopedic Surgery Orthopedics Oryctolagus cuniculus Patients Periosteum Physiologic pulse Precision therapeutics Procedures Prostate Proteolysis Quality of life Rehabilitation therapy Soft Tissue Injuries Somatotropin System Technology Therapeutic Thrombus Tissues Transducers Ultrasonic Therapy Ultrasonics Ultrasonography Work bone healing imaging capabilities improved injured long bone minimally invasive new technology response skeletal soft tissue stem cell therapy success ultrasound

项目摘要

PROJECT SUMMARY/ABSTRACT Over 40,000 children in the US are hospitalized for musculoskeletal deformities each year. Abnormal and often diminished skeletal growth is the root cause of many of these conditions. For years, periosteal resection has been shown to accelerate longitudinal bone growth. Previous attempts to surgically exploit this phenomenon as a growth accelerating therapeutic modality have produced variable results that have not justified the procedures’ surgical morbidity and has been a major barrier to widespread clinical use. Recently, we have developed technology capable of performing these procedures non-invasively. However, the current technology lacks the necessary targeting and imaging capabilities to measure and ensure proper energy delivery at the bone surface. Furthermore, the exact portion of the periosteum that must be injured to accelerate growth is unclear. Thus, in the first aim we will determine the component of the periosteum injured during open surgical periosteal resection responsible for physeal growth acceleration and in the second aim we will integrate targeting capabilities into our system to allow precise placement of energy on the periosteum to minimize adjacent soft tissue injury. At the completion of the proposed work, we will have furthered our goal of developing a simple, non-invasive method to modulate skeletal growth.

项目概要/摘要美国每年有超过 40,000 名儿童因肌肉骨骼异常而经常住院。多年来，骨膜切除术一直是导致许多此类疾病的根本原因。先前曾尝试通过手术利用这种现象，从而加速骨骼的纵向生长。作为一种生长加速治疗方式，已经产生了不同的结果，但这些结果并不能证明其合理性手术的手术发病率一直是广泛临床应用的主要障碍。然而，目前已开发出能够非侵入性执行这些程序的技术。技术缺乏必要的瞄准和成像能力来测量和确保适当的能量此外，必须损伤骨膜的确切部分。因此，在第一个目标中，我们将确定受伤骨膜的成分。在开放手术骨膜切除术期间，负责促进骨骺生长加速，在第二个目标中，我们将把靶向功能集成到我们的系统中，以便将能量精确地放置在骨膜上尽量减少邻近软组织损伤在完成拟议的工作后，我们将进一步实现以下目标：开发一种简单、非侵入性的方法来调节骨骼生长。