MRI: Acquisition of a GC Hybrid Orbitrap High Resolution Tandem Mass Spectrometer for Environmental Science

MRI：购买用于环境科学的 GC 混合 Orbitrap 高分辨率串联质谱仪

• 批准号: 1828257
• 负责人: Heather Stapleton
• 金额: $ 53.17万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828257&HistoricalAwards=false
• 关键词: MRI; Acquisition; GC; Hybrid; Orbitrap

This project is to acquire a state-of-the-art mass spectrometer that will help identify unknown chemicals pollutants and mixtures of chemicals in environmental samples, such as air, soil and personal exposure monitors. The instrument will be housed in the Duke Center for Environmental Exposomics. This equipment will serve as a resource to researchers and students spanning several departments on campus as well as for researchers within the central North Carolina region. Researchers will be able to submit samples to the facility manager, who will use the mass spectrometer to identify unknown chemicals in the samples with greater accuracy and confidence than has previously been available. The instrument will also be used to develop a new course to enhance graduate education in environmental and analytical chemistry. The course will teach students how to interrogate chemical structure databases using data generated by the mass spectrometer to make positive identification of chemicals, and to learn more about their sources, production volumes and fate in the environment. Acquisition of a high-resolution mass spectrometer will support structural elucidation of complex mixtures of unknown volatile and semi-volatile organic chemicals in the environment under study by researchers in central North Carolina. Access to this instrument will significantly advance research investigations on the fate, transport, and transformation of chemical pollutants found in complex mixtures in environmental samples that are the focus of several research centers on campus, including the Duke Center for Environmental Exposomics, the Duke Superfund Research Center, and the Center for Environmental Implications of Nanotechnology. The research projects outlined within this proposal share a focus on identifying complex mixtures of unknown or previously unidentified contaminants in environmental samples, which has been an obstacle to advancing research on chemical contaminants in the ambient environment. Major users of this instrument will engage in research to investigate not only exposure of environmentally relevant mixtures, but also research to improve and design sensors to detect contaminants at low levels and develop remediation tools and techniques to reduce the ecological risks associated with these contaminants. Seldom have such high-performance mass spectrometers been directly available in an academic setting, and acquisition of this instrument would enable Duke to become the only institution within the U.S. southeastern region to offer this support for environmental science research.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该项目将购买一台最先进的质谱仪，该质谱仪将有助于识别环境样本（例如空气、土壤和个人暴露监测器）中未知的化学污染物和化学混合物。该仪器将安置在杜克大学环境暴露组学中心。该设备将为校园多个部门的研究人员和学生以及北卡罗来纳州中部地区的研究人员提供资源。 研究人员将能够向设施经理提交样品，设施经理将使用质谱仪以比以前更高的准确性和置信度来识别样品中的未知化学物质。该仪器还将用于开发一门新课程，以加强环境和分析化学方面的研究生教育。该课程将教学生如何使用质谱仪生成的数据查询化学结构数据库，以对化学品进行积极的识别，并更多地了解其来源、产量和在环境中的归宿。购买高分辨率质谱仪将支持北卡罗来纳州中部研究人员研究的环境中未知挥发性和半挥发性有机化学物质的复杂混合物的结构阐明。使用该仪器将显着推进对环境样品中复杂混合物中化学污染物的归宿、迁移和转化的研究调查，这些研究是杜克大学环境暴露组学中心、杜克大学超级基金研究中心等校园多个研究中心的重点研究方向中心和纳米技术环境影响中心。该提案中概述的研究项目的共同重点是识别环境样本中未知或以前未识别的污染物的复杂混合物，这一直是推进周围环境中化学污染物研究的障碍。该仪器的主要用户将不仅参与研究与环境相关的混合物的暴露，还将研究改进和设计传感器以检测低水平的污染物，并开发修复工具和技术以减少与这些污染物相关的生态风险。这种高性能质谱仪很少能在学术环境中直接使用，购买该仪器将使杜克大学成为美国东南部地区唯一为环境科学研究提供这种支持的机构。该奖项反映了 NSF 的法定使命和通过使用基金会的智力价值和更广泛的影响审查标准进行评估，该项目被认为值得支持。

项目成果

Chemical contaminant exposures assessed using silicone wristbands among occupants in office buildings in the USA, UK, China, and India

使用硅胶腕带评估美国、英国、中国和印度办公楼居住者的化学污染物暴露情况

• DOI: 10.1016/j.envint.2021.106727
• 发表时间: 2021-11
• 期刊: Environment International
• 影响因子: 11.8
• 作者: Young, Anna S.;Herkert, Nicholas;Stapleton, Heather M.;Cedeño Laurent, Jose Guillermo;Jones, Emily R.;MacNaughton, Piers;Coull, Brent A.;James;Hauser, Russ;Luna, Marianne Lahaie;et al
• 通讯作者: et al

Characterization of Per- and Polyfluorinated Alkyl Substances Present in Commercial Anti-fog Products and Their In Vitro Adipogenic Activity

商业防雾产品中存在的全氟和多氟烷基物质的表征及其体外脂肪形成活性

• DOI: 10.1021/acs.est.1c06990
• 发表时间: 2022-01
• 期刊: Environmental Science & Technology
• 影响因子: 11.4
• 作者: Herkert, Nicholas J.;Kassotis, Christopher D.;Zhang, Sharon;Han, Yuling;Pulikkal, Vivek Francis;Sun, Mei;Ferguson, P. Lee;Stapleton, Heather M.
• 通讯作者: Stapleton, Heather M.

Comparative Assessment of Pesticide Exposures in Domestic Dogs and Their Owners Using Silicone Passive Samplers and Biomonitoring

使用硅胶被动采样器和生物监测对家犬及其主人的农药暴露进行比较评估

• DOI: 10.1021/acs.est.1c06819
• 发表时间: 2022-01-18
• 期刊: Environmental Science & Technology
• 影响因子: 11.4
• 作者: Wise, Catherine F.;Hammel, Stephanie C.;Herkert, Nicholas J.;Ospina, Maria;Calafat, Antonia M.;Breen, Matthew;Stapleton, Heather M.
• 通讯作者: Stapleton, Heather M.