MRI: Upgrade of a 600 MHz Spectrometer for high-sensitivity Nuclear Magnetic Resonance (NMR)

MRI：升级 600 MHz 光谱仪，用于高灵敏度核磁共振 (NMR)

• 批准号: 1828183
• 负责人: Jeffrey Johnson
• 金额: $ 44.48万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-10-01 至 2021-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1828183&HistoricalAwards=false
• 关键词: MRI; Upgrade; 600; MHz; Spectrometer

This award is supported by the Major Research Instrumentation, and the Chemistry Research Instrumentation programs. Professor Jeffrey Johnson from University of North Carolina at Chapel Hill and colleagues Gary Pielak, Alexander Miller, Jillian Dempsey and Bo Li have upgraded the console of a 600 MHz NMR spectrometer and have equipped the spectrometer with a cryoplatform to allow higher sensitivity. This will transform and old instrument into a modern spectrometer. This upgraded spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as allow study of biologically relevant species. In general, Nuclear Magnetic Resonance (NMR) spectroscopy is one of the most powerful tools available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution or in the solid state. Access to state-of-the-art NMR spectrometers is essential to chemists who are carrying out frontier research. The cryogenic probe provides a significant increase in sensitivity relative to standard NMR probes which permits use of small samples. The instrument is used for research and research training at this university and neighboring schools. The proposal is aimed at enhancing research and education at all levels. It especially impacts studies of complexity-building reactions from feedstock chemicals as well as utilization of proton-coupled electron transfer in solar fuel production. The spectrometer is used to investigate quantum dots and in the exploration of structural and functional diversity of microbial natural products and in the identification of new microbial natural products. The upgraded instrument is also employed in characterizing biosynthetic intermediates in natural product pathways and for probing mechanisms in sustainable organometallic catalysis. Fluorine NMR in cells is used to probe globular proteins.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要研究仪器和化学研究仪器项目支持。北卡罗来纳大学教堂山分校的 Jeffrey Johnson 教授及其同事 Gary Pielak、Alexander Miller、Jillian Dempsey 和 Bo Li 升级了 600 MHz NMR 波谱仪的控制台，并为波谱仪配备了冷冻平台，以实现更高的灵敏度。这会将旧仪器转变为现代光谱仪。这种升级后的光谱仪可以在多个领域进行研究，例如加速具有重大经济意义的化学反应的领域，以及可以研究生物学相关物种。一般来说，核磁共振 (NMR) 光谱是化学家阐明分子结构的最强大工具之一。它用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间相互作用的动力学。对于进行前沿研究的化学家来说，使用最先进的核磁共振波谱仪至关重要。相对于标准 NMR 探针，低温探针的灵敏度显着提高，允许使用小样品。该仪器用于该大学和邻近学校的研究和研究培训。该提案旨在加强各级研究和教育。它尤其影响对原料化学品复杂性构建反应的研究以及在太阳能燃料生产中利用质子耦合电子转移的研究。该光谱仪用于研究量子点、探索微生物天然产物的结构和功能多样性以及鉴定新的微生物天然产物。升级后的仪器还用于表征天然产物途径中的生物合成中间体以及探索可持续有机金属催化机制。细胞中的氟核磁共振用于探测球状蛋白。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Stepwise Iodide-Free Methanol Carbonylation via Methyl Acetate Activation by Pincer Iridium Complexes

通过钳铱络合物活化乙酸甲酯进行逐步无碘化物甲醇羰基化

• DOI: 10.1021/jacs.1c05185
• 发表时间: 2021-08
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Yoo, Changho;Miller, Alexander J.
• 通讯作者: Miller, Alexander J.

Temperature and Solvent Effects on H 2 Splitting and Hydricity: Ramifications on CO 2 Hydrogenation by a Rhenium Pincer Catalyst

温度和溶剂对 H 2 裂解和水度的影响：铼钳式催化剂对 CO 2 加氢的影响

• DOI: 10.1021/jacs.0c11110
• 发表时间: 2021-01
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: Hu, Jenny;Bruch, Quinton J.;Miller, Alexander J.
• 通讯作者: Miller, Alexander J.

Phenolic Oxidation Using H 2 O 2 via in Situ Generated para -Quinone Methides for the Preparation of para -Spiroepoxydienones

使用 H 2 O 2 进行酚醛氧化，通过原位生成对醌甲基化物来制备对螺环氧二烯酮

• DOI: 10.1021/acs.orglett.9b02372
• 发表时间: 2019-07
• 期刊: Organic Letters
• 影响因子: 5.2
• 作者: McLaughlin, Michael F.;Massolo, Elisabetta;Cope, Thomas A.;Johnson, Jeffrey S.
• 通讯作者: Johnson, Jeffrey S.

Stereodivergent Nucleophilic Additions to Racemic β-Oxo Acid Derivatives: Fast Addition Outcompetes Stereoconvergence in the Archetypal Configurationally Unstable Electrophile

外消旋β-含氧酸衍生物的立体发散亲核加成：快速加成胜过原型构型不稳定亲电子试剂的立体收敛

• DOI: 10.1021/jacs.1c07702
• 发表时间: 2021-10-06
• 期刊: Journal of the American Chemical Society
• 影响因子: 15
• 作者: De Jesús Cruz P;Crawford ET;Liu S;Johnson JS
• 通讯作者: Johnson JS

De Novo Synthesis of the DEF-Ring Stereotriad Core of the Veratrum Alkaloids

藜芦生物碱 DEF 环立体三联核心的从头合成

• DOI: 10.1021/acs.joc.0c00685
• 发表时间: 2020-05
• 期刊: The Journal of Organic Chemistry
• 作者: Horwitz, Matthew A.;Robins, Jacob G.;Johnson, Jeffrey S.
• 通讯作者: Johnson, Jeffrey S.