SBIR Phase I: Highly Potent Nanozeolite-based Silver Antimicrobials

SBIR 第一阶段：高效纳米沸石银抗菌剂

• 批准号: 1841732
• 负责人: Bo Wang
• 金额: $ 22.5万
• 依托单位: ZeoVation, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-02-01 至 2020-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1841732&HistoricalAwards=false
• 关键词: SBIR; Phase; Highly; Potent; Nanozeolite

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is providing a high potent antimicrobial solution for textiles, coatings, polymers, and wound care and bandages. There is considerable proliferation of antibiotic resistant bacteria, and, antimicrobials that do not develop resistance is of significant societal interest. Silver-based antimicrobials are filling this need, and are being used in a variety of medical, consumer and food-related applications. Silver is a broad-spectrum antimicrobial, effective against gram positive, gram negative bacteria (including methicillin-and vancomycin resistant bacteria) as well as fungi, viruses, and biofilms. This has led health care, consumer and food industries to use silver antimicrobial products. The global market for silver-based powder antimicrobial coatings is currently valued at $910 million and expected to grow at a compound annual growth rate (CAGR) of 13.1% until 2020. Concerns however, are increasing about the release of silver and the resulting influence on the environment. Development of high potency silver products using the minimum amount of silver can significantly broaden its use. The benefits of this versatile antimicrobial platform include: 1000-fold increased potency, decreased cost, invisibility and compatibility with formulations.This Small Business Innovation Research (SBIR) Phase I project will develop and test a highly potent silver-based antimicrobial product. Higher potency is due to control of size of ligand-free AgNP (1-3 nm) anchored to the surface of ~30 nm nanozeolite (NZ), and fast release of Ag+ within the zeolite. The bactericidal activity of AgNP-NZ has been examined with E. coli (gram negative) and antibiotic resistant MRSA (gram positive), with significant improvement. The potency is further enhanced by modifying the NZ support to introduce multiple features: increased antimicrobial activity via NZ ion-exchanged Zn2+, and surface modification of NZ to enhance interactions with bacteria, including penetration within the bacteria. At the conclusion of this SBIR Phase I project, the product will be ready for further commercialization and marketing by (1) demonstrating the scalability of the synthesis procedure so that there is enough supply of product in the product development process; (2) optimizing synthesis procedure of antimicrobial material according to antimicrobial property, including Ag+ and Zn2+ loading and surface modifications; (3) obtaining third party test reports on optimized samples as objective evidence for marketing and (4) studying the toxicity of the product toward mammalian cells to address toxicity concerns.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

这项小型企业创新研究（SBIR）I阶段项目的更广泛的影响/商业潜力为纺织品，涂料，聚合物以及伤口护理和绷带提供了高效的抗菌解决方案。抗生素抗性细菌存在相当大的扩散，并且不产生抗药性的抗菌剂具有重大的社会利益。基于银的抗菌剂正在满足这一需求，并用于各种医疗，消费者和食品相关的应用中。银是一种广谱抗菌素，有效地抗革兰氏阳性，革兰氏阴性细菌（包括甲氧西林和万古霉素耐药细菌）以及真菌，病毒和生物膜。这导致医疗保健，消费者和食品行业使用银抗菌产品。 目前，全球粉末抗菌抗菌涂料的市场价值为9.1亿美元，预计将以13.1％的复合年增长率（CAGR）增长，直到2020年。但是，人们对释放白银的释放以及对环境的影响有所增加。使用最低量的白银开发高效力银产品可以显着扩大其使用。这个多功能抗菌平台的好处包括：提高效力，成本下降，隐身性和与配方的兼容性。这项小型企业创新研究（SBIR）I阶段项目将开发并测试高度有效的基于银的抗菌产品。较高的效力是由于控制了锚定在〜30 nm纳米唑（NZ）表面的无配体AGNP（1-3 nm）的大小以及在沸石中快速释放的Ag+。 已使用大肠杆菌（革兰氏阴）和抗生素MRSA（革兰氏阳性）检查了AGNP-NZ的杀菌活性，并具有显着改善。通过修改NZ支持以引入多种特征来进一步提高效力：通过NZ离子交换的Zn2+增加抗菌活性，以及​​对NZ的表面修饰以增强与细菌的相互作用，包括在细菌中渗透。在此SBIR I阶段项目的结论中，该产品将通过（1）证明合成程序的可扩展性来准备进一步的商业化和营销，以便在产品开发过程中有足够的产品供应； （2）根据抗菌特性，优化抗菌材料的合成程序，包括Ag+和Zn2+载荷和表面修饰； （3）获取有关优化样本的第三方测试报告作为营销的客观证据，以及（4）研究产品对哺乳动物细胞的毒性以解决毒性问题。这项奖项反映了NSF的法定任务，并被认为是值得通过基金会的知识分子优点和更广泛的审查标准来通过评估来支持的。