PFI:AIR - TT: Electroactive Scaffold for Cartilage Regeneration: A Proof of Concept Study

PFI:AIR - TT：用于软骨再生的电活性支架：概念研究验证

基本信息

批准号：
1700945
负责人：
Treena Livingston
金额：
$ 20万
依托单位：
New Jersey Institute of Technology
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-07-15 至 2019-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1700945&HistoricalAwards=false
关键词：
PFI AIR TT Electroactive Scaffold

项目摘要

This PFI: AIR Technology Translation project focuses on translating the use of a smart biomaterial for the application of cartilage repair. The project will utilize a piezoelectric material to regenerate cartilage tissue. Piezoelectric materials are capable of converting mechanical deformation into electrical output and have largely been unexplored for cartilage repair. An estimated 49 million Americans suffer from cartilage damage as a result of injury, or wear and tear with aging, which can significantly affect a person's quality of life and can progress to widespread cartilage destruction and disabling arthritis. At present, current repair techniques are unable to restore a normal "hyaline" cartilaginous surface, resulting in fibrous "scars" that do not return the joint to normal function. The project will result in the development of a piezoelectric scaffold prototype for implantation and will determine whether the piezoelectric scaffold will regenerate functional cartilage tissue. Proof-of-concept will be demonstrated. The piezoelectric scaffold has the following unique features: mechanically flexible, biodegradable, porous for tissue ingrowth and cell attachment, and provides electrical stimulation. For treating cartilage defects, the piezoelectric scaffold can be combined with microfracturing, a common surgical procedure that stimulates the bone marrow and provides a source of endogenous stem cells, to promote healing and integration with the native cartilage.This project addresses the following technology gap(s) as it translates from research discovery toward commercial application. The piezoelectric scaffold is a composite consisting of zinc oxide, which possesses both piezoelectric and biological growth factor properties. A piezoelectric material acts as a highly sensitive mechano-electrical transducer that generates charges in response to minute mechanical deformations. This project will develop a flexible, piezoelectric fibrous scaffold that can achieve a local electric field mimicking the natural extracellular matrix observed during development and regeneration. This natural extracellular matrix is also rich in growth factors so the bifunctional property of zinc will provide a synergistic benefit to cells to promote repair. The proposed studies will focus on prototype development and establishing proof-of-concept in an in vivo model. Many individuals suffer from osteoarthritis or cartilage damage. Innovative technologies are needed. Personnel involved in this project, both undergraduate and graduate students, and postdocs, will receive entrepreneurship, innovation and technology translation experiences through teaching modules and university programs.

该PFI：空气技术翻译项目的重点是翻译使用智能生物材料来应用软骨维修。该项目将利用压电材料来再生软骨组织。压电材料能够将机械变形转换为电输出，并且在很大程度上是意外的软骨修复。估计有4900万美国人因受伤或随着衰老而磨损而遭受软骨损伤，重要的是要影响一个人的生活质量，并可以发展到宽大的软骨破坏和致残关节炎。目前，当前的修复技术无法恢复正常的“透明”软骨表面，从而导致纤维“疤痕”不会使关节返回正常功能。该项目将导致打电话给植入的压电支架原型，并确定压电支架是否会再生功能性软骨组织。概念证明将被证明。压电支架具有以下独特的特征：机械柔性，可生物降解，可用于组织内部和细胞附着的多孔，并提供电刺激。为了治疗软骨缺陷，可以将压电支架与微裂缝结合使用，这是一种刺激骨髓的常见手术程序，并提供了内源性干细胞的来源，可以促进与天然软骨的愈合和整合。该项目从下面的技术差距中介绍了从研究发现的涉及商业发现的下列技术差距。压电支架是由氧化锌组成的复合材料，该复合材料具有压电和生物生长因子特性。压电材料充当高度敏感的机械换能器，可响应微小的机械变形而产生电荷。该项目将开发一个灵活的压电纤维支架，可以实现模仿在发育和再生过程中观察到的天然细胞外基质的局部电场。这种天然的细胞外基质也具有丰富的生长因子，因此锌的双功能特性将为细胞提供协同的益处，以促进修复。拟议的研究将集中于原型开发并在体内模型中建立概念验证。许多人患有骨关节炎或软骨损伤。需要创新技术。参与该项目的人员，本科生和研究生以及博士后，将通过教学模块和大学课程获得企业家，创新和技术翻译经验。