STTR Phase II: Development and commercialization of a Wearable Long-term Monitor for Cardiac Arrhythmias

STTR 第二阶段：可穿戴式心律失常长期监测仪的开发和商业化

• 批准号: 1660253
• 负责人: Dennis Matthews
• 金额: $ 75万
• 依托单位: Cardiac Motion, LLC
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2020-02-29
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1660253&HistoricalAwards=false
• 关键词: STTR; Phase; II; Development; commercialization

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase II project is far-reaching in terms of improving the quality of life and the cost/efficacy of healthcare for more than 20 Million people in the USA. We address the need for better methods for identifying and guiding the treatment of ambulatory patients with dangerous heart dysfunctions such as intermittent arrhythmias and heart failure. For example, atrial fibrillation arrhythmia afflicts nearly 8 Million patients in the USA, approximately 460,000 new patients every year, and the patient load is projected to grow to 12.1 million by 2050. The disease and its complications (stroke, congestive heart failure, seizures, death, etc.) add $26B to the nation's annual healthcare costs. Heart Failure currently afflicts nearly 5.7 Million people in the US growing to 8 Million by 2030. Their treatment and frequent hospitalization costs are already at 14B$ and will grow to 29B$ by 2030. Together with reducing the economic impacts, it would be of an enormous benefit to human health to create a device that improves the diagnosis and guides effective therapy for these patients while they remain fully ambulatory and going about their normal activities outside the expensive confines of the hospital. The proposed project has the following intellectual merits. In our Phase I STTR program we focused on developing a wearable Atrial Fibrillation monitor to assist physicians in the diagnosis of paroxysmal or episodic versions of that disorder. In Phase II we have pivoted towards the even more critical need of ambulatory monitoring of paroxysmal tachycardia and eventually heart failure patients. The current industry standard of ambulatory ECG does not provide enough sensitivity or specificity to determine if the patient has atypical or typical atrial flutter, paroxysmal supraventricular tachycardia as well as various forms of ventricular tachycardia. Accurately diagnosing and monitoring these disorders is critical to patient treatment and outcomes. Our device will be capable of ambulatory patient monitoring for any sort of arrhythmia, and we believe it can be the preferred choice for all portable monitoring if it provides in one device ECG, heart motion and breathing rate/pattern/volume. So, the overarching technical research goal of our Phase II work is to develop a full featured prototype cardiac motion sensor as described above that can be used for initial clinical tests. These features include: wearable, battery powered, signal storage, cardiac motion from radar, disposable antenna, onboard ECG, and breathing rate.

这一小型企业技术转移（STTR）II期项目的更广泛的影响/商业潜力在改善了美国超过2000万人的生活质量以及医疗保健的成本/效率方面的影响很高。我们解决了需要更好地识别和指导患有危险心脏功能障碍（例如间歇性心律失常和心力衰竭）的门诊患者的更好方法。例如，房颤心律失常遭受了近800万患者，每年约460,000名新患者，并且预计到2050年，患者负荷将增长到1,210万。疾病及其并发症（中风，心脏衰竭，癫痫发作，死亡，死亡等）为国家的年度医疗保健增长了26B美元。目前，心力衰竭到2030年，美国近570万人增加到800万人。他们的治疗和频繁的住院费用已经为14b $，到2030年将增长到29b $。随着降低经济影响，这将对人类健康产生巨大的好处，可以使他们的诊断和指导性的良好型和指导性的稳定性及其稳定的稳定性，并使他们保持正常状态，并使他们保持昂贵的态度，并且可以使他们的稳定范围既昂贵。 拟议的项目具有以下智力优点。在我们的I阶段ISTTR计划中，我们专注于开发可穿戴的房颤监测器，以帮助医生诊断该疾病的阵发性或情节版本。在第二阶段，我们朝着对阵发性心动过速和最终心力衰竭患者的卧床监测更加迫切的需求。当前的行业心电图的行业标准没有提供足够的灵敏度或特异性，无法确定患者是否具有非典型或典型的心房颤动，阵发性障碍性心动过速以及各种形式的心室心动过速。准确诊断和监测这些疾病对于患者治疗和结果至关重要。我们的设备将能够对任何一种心律不齐的患者进行门诊监测，我们认为，如果它在一个设备ECG，心脏运动和呼吸率/模式/体积中提供，则可以选择所有便携式监控。因此，我们II期工作的总体技术研究目标是开发一个完整的特色心脏运动传感器，如上所述，可用于初始临床测试。这些功能包括：可穿戴，电池供电，信号存储，雷达的心脏运动，一次性天线，板载ECG和呼吸速率。

项目成果

Measurement of the Complex Human Atrial-Ventricular Motions using Contact-Based Doppler Radar

• DOI: 10.1109/wamicon.2019.8765441
• 发表时间: 2019-04
• 期刊: 2019 IEEE 20th Wireless and Microwave Technology Conference (WAMICON)
• 作者: Xiaomeng Gao;Xiaonan Jiang;Songjie Bi;D. Matthews;S. Schaefer;X. Liu

Coupling-Cancellation-Antenna for Improving Doppler Radar Motion Measurement Accuracy

用于提高多普勒雷达运动测量精度的耦合消除天线

• DOI: 10.1109/wamicon.2019.8765442
• 发表时间: 2019
• 期刊: 2019 IEEE 20th Wireless and Microwave Technology Conference (WAMICON
• 作者: Bi, Songjie;Jiang, Xiaonan;Gao, Xiaomeng;Liu, Xiaoguang
• 通讯作者: Liu, Xiaoguang

A Multi-Arc Method for Improving Doppler RadarMotion Measurement Accuracy

提高多普勒雷达运动测量精度的多弧法

• DOI: 10.1109/mwsym.2018.8439687
• 发表时间: 2018
• 期刊: 2018 IEEE/MTT-S International Microwave Symposium - IMS
• 作者: Bi, Songjie;Gao, Xiaomeng;Lubecke, Victor M.;Lubecke, Olga Boric-;Matthews, Dennis;Liu, Xiaoguang Leo
• 通讯作者: Liu, Xiaoguang Leo