SBIR Phase II: Anti-fouling surface modifications for purification membranes

SBIR第二阶段：净化膜的防污表面改性

• 批准号: 1660225
• 负责人: Adam Paxson
• 金额: $ 72.4万
• 依托单位: DropWise Technologies Corp.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1660225&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Anti; fouling

This Small Business Innovation Research (SBIR) Phase II project will address the challenge of fouling on membranes used in biopharmaceutical processing. The successful application of this coating would enable increase in the membrane lifetime and product yield of various production streams as less of the valuable compounds remain trapped in the membrane. This can increase production capacity for life-saving medicines, reduce production costs and, in certain cases, enable continuous biopharmaceutical manufacturing. Furthermore, functionalization of membranes currently involve significant quantities of environmentally harmful solvents, which may be leachable during usage of the membrane. This issue is avoided in the current project by utilizing initiated chemical vapor deposition (iCVD) process which does not require any solvent. This coating technology can also be extended to other systems including wastewater purification, food & beverage production, industrial separations, and medical devices that rely on a similar functionalization.The objective of Phase II will be to demonstrate a commercially viable manufacturing process to produce surface modifications within porous membranes using the iCVD process. Previous work in this subject has focused on top-coats on the top surfaces of reverse osmosis membranes, but the chemistries utilized have never before been demonstrated within interior structures of the membrane filters. During the Phase II work, the performance of the coatings will be optimized by using existing deposition equipment to tune the coating chemistry and process conditions to maximize the flux and throughput by minimizing protein fouling. The other main technical goal of the work will be to translate the current batch process into a continuous roll-to-roll process that is amenable to large-scale manufacturing. The outcome of this study will be a proven coating chemistry that is effective and durable in the membrane application, and an optimized manufacturing process capable of being implemented within current standards of membrane manufacturing.

这项小型企业创新研究（SBIR）第二阶段项目将解决对生物制药处理中使用的膜的结垢挑战。由于较少的有价值的化合物仍然被困在膜中，因此成功应用这种涂层将使各种生产流的膜寿命和产品产量增加。这可以提高挽救生命的药物的生产能力，降低生产成本，并在某些情况下实现连续的生物制药制造。此外，膜的功能化目前涉及大量环境有害溶剂，在膜使用过程中可能是可渗出的。当前项目通过利用不需要任何溶剂的化学蒸气沉积（ICVD）过程来避免此问题。该涂料技术还可以扩展到其他系统，包括废水净化，食品和饮料生产，工业分离以及依赖类似功能化的医疗设备。第二阶段的目标是证明使用ICVD工艺在多孔膜内产生表面修饰的商业可行的制造过程。该主题的先前工作集中在逆渗透膜顶部表面上的顶级涂层上，但是在膜过滤器的内部结构中，所使用的化学物质从未被证明。在第二阶段的工作中，将通过使用现有的沉积设备来调整涂料化学和过程条件来优化涂料的性能，从而最大程度地减少蛋白质结垢，从而最大程度地提高通量和吞吐量。这项工作的另一个主要技术目标是将当前的批处理过程转换为可容纳大型制造的连续卷到滚动过程。这项研究的结果将是一种经过验证的涂料化学，在膜应用中是有效耐用的，并且可以在当前膜制造标准中实施的优化制造工艺。