Conference: 4th Penn State Bioinorganic Workshop and the 4th "Frontiers in Metallobiochemistry" Symposium to be held at Penn State University; June 2 - June 10, 2016

会议：第四届宾夕法尼亚州立大学生物无机研讨会和第四届“金属生物化学前沿”研讨会将在宾夕法尼亚州立大学举行；

• 批准号: 1641159
• 负责人: Carsten Krebs
• 金额: $ 1万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1641159&HistoricalAwards=false
• 关键词: Conference; 4th; Penn; State; Bioinorganic

Enzymes containing transition metal ions in their active sites catalyze some of the most important and difficult chemical reactions in biology, including the reduction of nitrogen to ammonia, the oxidation of water to oxygen in photosynthesis, and the stereospecific functionalization of unactivated carbon-hydrogen bonds. The area of bioinorganic chemistry aims to understand the role that metal ions play in bio-catalytic processes and use this understanding to enable the design of new bio-inspired catalysts. The efforts are important to society, because they may facilitate, for example, the generation of renewable energy (e.g. solar energy conversion and bioproduction of renewable fuels) to power the planet. It may also facilitate the production of cheaper fertilizers for agriculture. The field of bioinorganic chemistry is diverse and includes a wide variety of scientific disciplines, including genetics, molecular biology, biochemistry, biophysics, bioinformatics, analytical chemistry, and physical chemistry. Many different experimental techniques and theoretical methods are combined to study the formation, function and regulation of the metal cofactors, as well as the mechanism of these metal-containing enzymes. For these reasons, research in this area is generally highly collaborative. This workshop will train students, postdoctoral scholars and faculty members from primarily undergraduate institutions in the area of bioinorganic chemistry, setting the stage for future discoveries in this exciting field. With this award, the Molecular Biophysics Program in the Molecular and Cellular Biosciences Division and the Chemistry of Life Processes Program in the Chemistry Division is co-funding a biennial training workshop, which is led by Prof. Carsten Krebs and colleagues at the Department of Chemistry at The Pennsylvania State University. The 2016 workshop provides training for approximately 150 participants and encompasses (i) 17 lectures by faculty experts in the field in their area of specialty, (ii) hands-on training in 21 different methods offered to small groups of up to 6 participants in 2-hour time-blocks (repeated up to 12 times) and taught by 70 student/postdoc/faculty experts in bioinorganic methods and (iii) research presentations in the form of posters and 12 talks by selected students and postdoctoral scholars. This workshop will uniquely train the next generation of researchers in the field of bioinorganic chemistry.

含有过渡金属离子的活性位点中含有过渡金属离子的酶催化了生物学中最重要，最困难的化学反应，包括氮对氨的降低，光合作用中的水对氧的氧化以及未激活的碳 - 碳纤维基因键的立体特异性功能化。 生物无机化学区域旨在了解金属离子在生物催化过程中的作用，并利用这种理解来设计新的生物启发的催化剂。 这些努力对社会很重要，因为它们可能会促进可再生能源的产生（例如太阳能转化和可再生燃料的生物生产）来为地球供电。 它也可能有助于生产更便宜的农业肥料。 生物无机化学领域是多种多样的，包括各种科学学科，包括遗传学，分子生物学，生物化学，生物物理学，生物信息学，分析化学和物理化学。 将许多不同的实验技术和理论方法组合在一起，以研究金属辅因子的形成，功能和调节，以及这些含金属酶的机理。 由于这些原因，该领域的研究通常是高度协作的。 该研讨会将培训来自生物促进化学领域的主要本科机构的学生，博士后学者和教职员工，为这个令人兴奋的领域的未来发现奠定了基础。有了这个奖项，分子和细胞生物科学师的分子生物物理学计划以及化学划分中的化学过程计划的化学过程正在共同资助了一项两年一的培训研讨会，该研讨会由宾夕法尼亚州立大学的Carsten Krebs教授和化学学院领导。 2016年的研讨会为大约150名参与者和包容的培训提供了培训（i）在其专业领域的教师专家的17次讲座，（ii）21种不同的方法为21种不同的方法提供了21种不同的方法，可为2个小时的2小时时间障碍（重复12次），并在70个学生/后的研究中教授IIS/Faceult Peacters（Bio inie inii in II in II in IIN）（bio inig offer）。选定学生和博士后学者的海报和12次演讲的形式。 该研讨会将独特地培训生物促进化学领域的下一代研究人员。