CAREER: SusChEM: Nickel Catalyzed Arylation: Reaction Development and Mechanistic Investigation

职业：SusChEM：镍催化芳基化：反应开发和机理研究

• 批准号: 1554630
• 负责人: Dipannita Kalyani
• 金额: $ 40万
• 依托单位: Saint Olaf College
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1554630&HistoricalAwards=false
• 关键词: CAREER; SusChEM; Nickel; Catalyzed; Arylation

In this CAREER project funded by the Chemical Catalysis Program of the Chemistry Division, Professor Kalyani of the Department of Chemistry at St. Olaf College is developing Ni-catalyzed methods to construct biaryl bonds. Biaryls are used for numerous commercial applications. New carbon-carbon bond forming reactions using readily available, inexpensive and/or renewable substrates and earth abundant Ni-catalysts are being developed. These studies may ultimately contribute to the design of more economical and greener processes for the production of compounds prevalent in pharmaceutical, agrochemical and material science industries. St. Olaf undergraduate researchers benefit from a state-of-the-art experience in organometallic catalysis, a possible prelude to careers at national labs, employment in the chemical or pharmaceutical industry, or faculty appointments. The research program strengthening the scientific work force. In addition, Professor Kalyani has designed a course to introduce non-science students to science by addressing global economic and sustainability challenges. Finally, in collaboration with the St. Olaf College Upward Bound Program for high school students, outreach activities introduce minority and disadvantaged students to the exciting world of organometallic chemistry in our everyday lives.Transition metal catalyzed methods for the construction of biaryl compounds are well-established. However, the vast majority of these methods use expensive precious-metal catalysts such as palladium and rhodium. Furthermore, aryl halides are the most common coupling partners employed for these reactions, and their use leads to environmentally undesirable halide wastes. Professor Kalyani's research program addresses these limitations through the use of earth-abundant nickel (Ni)-catalysts and non-halide aryl sources. The insights gained from the mechanistic studies may be helpful in the design of versatile new Ni-catalyzed reactions capable of activating carbon (C)-hydrogen (H), C-oxygen (O) and C-C bonds. Both high school and college students participate in Professor Kalyani's research project, where they are introduced to chemistry and develop a sound foundation to conduct, interpret, and communicate scientific research.

在化学部化学催化计划资助的这项职业项目中，圣奥拉夫学院化学系的Kalyani教授正在开发建造Biaryl债券的NI催化方法。 Biaryls用于众多商业应用。使用易于使用的，廉价和/或可再生的底物和地球丰富的Ni-catalysts形成新的碳碳键反应。这些研究最终可能有助于设计更经济，更绿色的过程，以生产药物，农业和材料科学行业中普遍存在的化合物。圣奥拉夫本科研究人员受益于有机金属催化的最先进经验，在国家实验室的职业，化学或制药行业的就业或教职员工任命的可能性。研究计划加强了科学劳动力。此外，Kalyani教授设计了一门课程，通过应对全球经济和可持续性挑战，将非科学学生介绍给科学。最后，在我们的日常生活中，与圣奥拉夫学院的高中学生合作，外展活动将少数群体和处境不利的学生介绍给令人兴奋的有机金属化学世界。转机金属催化的催化方法是建造二元组的方法。已确立的。但是，这些方法中的绝大多数都使用了昂贵的珍贵金属催化剂，例如钯和铑。此外，芳基卤化物是这些反应采用的最常见的耦合伙伴，它们的使用导致环境不受欢迎的卤化物废物。 Kalyani教授的研究计划通过使用土壤丰富的镍（NI） - 催化剂和非盐酸芳基来解决这些局限性。从机械研究中获得的见解可能有助于设计能够激活碳（C）氢（H），C-氧（O）和C-C键的多功能新Ni催化反应。高中生和大学生都参加了Kalyani教授的研究项目，在那里他们被介绍给化学，并为进行，解释和交流科学研究提供合理的基础。