MRI: Acquisition of an Ultrahigh Resolution Mass Spectrometer for Interdisciplinary Research and Education

MRI：购买超高分辨率质谱仪用于跨学科研究和教育

• 批准号: 1531454
• 负责人: Lynn Mazzoleni
• 金额: $ 54.01万
• 依托单位: Michigan Technological University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-10-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1531454&HistoricalAwards=false
• 关键词: MRI; Acquisition; Ultrahigh; Resolution; Mass

Mass spectrometry instruments with ultrahigh mass resolution and extreme sensitivity are especially well suited for the analysis of complex environmental samples, such as found in the organic mixtures in atmospheric aerosols, and a range of natural waters and hydrometeors. The proposal seeks to acquire and commission an ultrahigh mass resolution Thermo Orbitrap Elite MS, with high mass resolution aiding in more accurate molecular weight determination, and interfaced with 2-D liquid chromatography to aid in separation in mixtures of like compounds. Molecular signatures and relative quantities of molecules in complex mixtures will be used initially to further our understanding of: (1) atmospheric aerosol processes (e.g., cloud cycling and aging) and properties (e.g., hygroscopicity and volatility); (2) carbon cycling responses to changes in biota and climate; and additional applications such as: (3) multiphase reaction chamber work; (4) fate of organic contaminants during water treatmentAdvanced analytical instrumentation also significantly expands the research opportunities and training exercises for students, postdocs and the next generation of researchers/teachers.

具有超高质量分辨率和极高灵敏度的质谱仪器特别适合分析复杂的环境样品，例如在大气气溶胶中的有机混合物中发现的，以及一系列的天然水和水直觉者。该提案旨在获取和委托超高质量分辨率热轨道精英MS，高质量分辨率以更准确的分子量测定为辅助，并与2-D液相色谱法连接，以帮助分离类似化合物的混合物。最初将使用分子特征和复杂混合物中分子的相对量来进一步理解：（1）大气气溶胶过程（例如，云循环和老化）和特性（例如，吸湿性和波动率）； （2）碳循环对生物群和气候变化的反应；以及其他应用，例如：（3）多相反应室工作； （4）水处理仪器期间有机污染物的命运还显着扩大了学生，博士后和下一代研究人员/教师的研究机会和培训练习。