Development of a novel single-scan acquisition and model-based reconstruction method for fast, accurate and robust multi-parametric quantitative MRI at ultrahigh field strength

开发一种新型单扫描采集和基于模型的重建方法，用于超高场强下快速、准确和鲁棒的多参数定量 MRI

• 批准号: 446320670
• 负责人: Dr. Markus Zimmermann
• 金额: --
• 依托单位: INM-4: Physik der Medizinischen Bildgebung
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2020
• 资助国家: 德国
• 起止时间: 2019-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/446320670?language=en
• 关键词: Development; novel; single; scan; acquisition

Quantitative magnetic resonance imaging (qMRI) allows a multitude of physiological MR parameters to be measured. Among those, the following parameters are considered significant as they are known to be affected by several neurological pathologies: water content, longitudinal relaxation time T1, effective transverse relaxation time T2*, magnetic susceptibility, and electric conductivity. Conventional methods which can be used to measure these parameters either suffer from long acquisition times and are sensitive to patient motion, tarnishing their clinical applicability, or are susceptible to magnetic field inhomogeneity and have a high specific absorption rate, which impairs their application at ultrahigh field strength. The aim of this project is to develop a novel qMRI method to simultaneously map the aforementioned parameters, which is designed to be fast, accurate, and motion-robust, while simultaneously being robust against magnetic field inhomogeneity and having a low specific absorption rate. This makes it both clinically applicable and also well suited for application at ultrahigh field strength. The proposed method consists of a new MR sequence and a new image reconstruction technique to produce hundreds of contrast images with 1mm isotropic resolution and full brain coverage within only 5-7 minutes of acquisition time. These images are acquired at different echo and inversion times and form the basis of the subsequent quantitative parametric mapping.

定量磁共振成像 (qMRI) 可以测量多种生理 MR 参数。其中，以下参数被认为是重要的，因为已知它们受到几种神经病理学的影响：含水量、纵向弛豫时间 T1、有效横向弛豫时间 T2*、磁化率和电导率。可用于测量这些参数的传统方法要么采集时间长并且对患者运动敏感，从而损害了其临床适用性，要么容易受到磁场不均匀性的影响并且具有高比吸收率，这损害了它们在超高场中的应用力量。该项目的目的是开发一种新颖的 qMRI 方法来同时映射上述参数，该方法被设计为快速、准确和运动鲁棒性，同时对磁场不均匀性具有鲁棒性并具有较低的比吸收率。这使得它既适用于临床，也非常适合超高场强的应用。所提出的方法由新的 MR 序列和新的图像重建技术组成，可在仅 5-7 分钟的采集时间内生成数百张各向同性分辨率和全脑覆盖的对比图像。这些图像是在不同的回波和反演时间获取的，并构成后续定量参数映射的基础。