Raman enhancements in coupled nanostructures for TERS imaging

用于 TERS 成像的耦合纳米结构的拉曼增强

• 批准号: 1507287
• 负责人: Zachary Schultz
• 金额: $ 44.02万
• 依托单位: University of Notre Dame
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-01 至 2018-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1507287&HistoricalAwards=false
• 关键词: Raman; enhancements; coupled; nanostructures; TERS

With this award, the Chemical Measurement and Imaging program of the Division of Chemistry is funding Professor Zachary D. Schultz of the University of Notre Dame to explore ways to enhance the signal from molecular samples being imaged by a scanning probe microscope. A type of light scattering (Raman scattering) can reveal information about the structure of molecules. In a scanning probe experiment, the probe tip can enhance the Raman scattering signal (this is called tip-enhanced Raman scattering, or 'TERS'). Professor Schultz is investigating the origin of Raman signal enhancements observed from nanostructures coupled with tip enhanced Raman scattering (TERS) imaging. The instrumentation and methodology is being used in collaboration with Snite Museum of Art to identify pigments in medieval artwork and aid conservation studies. The incorporation of graduate and undergraduate students in this research provides a platform for promoting measurement science and a training opportunity for the students to gain research skills relevant to academic research and commercial interests.The project focuses on understanding the plasmonic effects that give rise to chemical specific signals in TERS experiments. TERS imaging combined with hyperspectral dark-field microscopy determines the plasmon modes and Raman scattering arising from the interaction of a TERS-tip with various sized and shaped nanoparticles (NPs). The electric fields experienced by molecules around the nanostructures are being studied by vibrational frequency shifts rather than signal intensity. Chemical functionalization of the TERS tip and the surface is being used to study the location of the molecules that give rise to the observed TERS signals. The sensitivity of the TERS measurements is being investigated to determine the possibility of single protein studies. This project has the potential to enable chemical characterization of protein receptors in intact cell membranes.

凭借该奖项，化学系的化学测量和成像项目正在资助圣母大学的 Zachary D. Schultz 教授探索增强扫描探针显微镜成像的分子样品信号的方法。 一种光散射（拉曼散射）可以揭示有关分子结构的信息。 在扫描探针实验中，探针尖端可以增强拉曼散射信号（这称为尖端增强拉曼散射，或“TERS”）。舒尔茨教授正在研究从纳米结构与尖端增强拉曼散射（TERS）成像相结合观察到的拉曼信号增强的起源。与 Snite 艺术博物馆合作使用该仪器和方法来识别中世纪艺术品中的颜料并帮助保护研究。研究生和本科生参与这项研究为促进测量科学提供了一个平台，并为学生获得与学术研究和商业利益相关的研究技能提供了培训机会。该项目的重点是了解引起化学特异性的等离子体效应TERS 实验中的信号。 TERS 成像与高光谱暗场显微镜相结合，确定了 TERS 尖端与各种尺寸和形状的纳米颗粒 (NP) 相互作用所产生的等离激元模式和拉曼散射。纳米结构周围分子所经历的电场正在通过振动频移而不是信号强度来研究。 TERS 尖端和表面的化学功能化用于研究产生观察到的 TERS 信号的分子的位置。正在研究 TERS 测量的灵敏度，以确定单一蛋白质研究的可能性。该项目有可能对完整细胞膜中的蛋白质受体进行化学表征。