Collaborative Research: Using protein function prediction to promote hypothesis-driven thinking in undergraduate biochemistry education

合作研究：利用蛋白质功能预测促进本科生物化学教育中的假设驱动思维

• 批准号: 1503699
• 负责人: Rebecca Roberts
• 金额: $ 3.25万
• 依托单位: Ursinus College
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-15 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1503699&HistoricalAwards=false
• 关键词: Collaborative; Research; Using; protein; function

Recognizing the national need for significant improvement in undergraduate STEM education, collaborators from six institutions (Rochester Institute of Technology, St. Mary's University, Oral Roberts University, Hope College, Ursinus College, and California Polytechnic University) will explore a new approach to introduce students to authentic research in biochemistry laboratory courses. The project will test the hypotheses that engaging in authentic research will improve students' abilities to master key aspects of experimentation (experimental design, data processing and interpretation, and communication of research outcomes) and visualization (use of representations to communicate various aspects of the research process). The project is likely to be transferrable to other institutions, and is an example of a cost-effective way to introduce course-based research into the undergraduate curriculum.Biochemistry laboratory courses will be redesigned to include modules in which students will integrate computational and wet lab techniques as they characterize proteins whose three dimensional structures are known but to which functions have not been previously ascribed. Because the project is focused on discovery, it is reasonable to expect that some of the students will produce novel results that will contribute to the field of biochemistry. Formative and summative evaluation will address assessment of student learning gains in terms of improved conceptual understanding and visualization of experiments using a validated instrument composed of open-ended and closed-ended questions. Faculty members and teaching assistants will be surveyed and interviewed about their satisfaction with the project, its usability, and the extent to which they see the project as part of their own and their students' development. The project team will create and disseminate modules (promol.org) that form the core of a new curriculum for undergraduate biochemistry laboratory courses. The results of the work will be presented at professional meetings, such as the American Society of Biochemistry and Molecular Biology, and submitted to scholarly journals.

认识到全国范围内的STEM教育的全国性需求，来自六家机构（罗切斯特理工学院，圣玛丽大学，口服罗伯茨大学，希望学院，Ursinus College和California Polytechnic University）的合作者将探索一种新方法，将学生介绍给学生在生物学实验室实验室实验室研究中的学生。 该项目将测试从事真实研究的假设将提高学生的能力来掌握实验的关键方面（实验设计，数据处理和解释以及研究成果的交流）和可视化（使用表示形式来交流研究过程的各个方面）。 该项目可能可以转移到其他机构，这是一种具有成本效益的方式的一个例子，可以重新设计基于课程的研究。BioChemistry实验室课程将包括模块，包括学生将计算和湿法的湿润技术集成到其三个上限结构中的蛋白质，但以前已知的蛋白质以前是该功能的蛋白质，而这些蛋白质的表征是在此之前既不知道的。 由于该项目的重点是发现，因此可以合理地期望一些学生将产生新颖的结果，从而有助于生物化学领域。 形成性和总结性评估将通过使用由开放式和封闭式问题组成的经过验证的工具对实验的概念理解和可视化来解决对学生学习收益的评估。 将对教职员工和助教进行调查和采访，以了解他们对项目的满意度，其可用性以及他们将项目视为自己的一部分以及学生发展的程度。 项目团队将创建和传播模块（Promol.org），这是本科生物化学实验室课程的新课程的核心。 这项工作的结果将在专业会议上介绍，例如美国生物化学和分子生物学学会，并提交学术期刊。