RCN: A Network to Promote Comparative Genome to Phenome Analysis

RCN：促进比较基因组与表型组分析的网络

• 批准号: 1456942
• 负责人: Carl Schmidt
• 金额: $ 50万
• 依托单位: University of Delaware
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1456942&HistoricalAwards=false
• 关键词: RCN; Network; Promote; Comparative; Genome

Understanding the relationship between an organism's DNA (the genome) and the set of phenotypic characteristics that result from genomic expression (the phenome) is a central challenge in biology. High throughput sequencing and phenotypic data from multiple species provides an opportunity for comparative analysis of genome to phenome data. The objective of this award is to develop a Genome to Phenome Network (G2PN) Research Collaboration Network (RCN) aimed at promoting comparative analysis of vertebrate and invertebrate animals to enrich our understanding of the relationship between genomes and phenomes. The G2PN will bring together groups using diverse experimental approaches to understand how the genome ultimately manifests the phenome. The G2PN will provide tools necessary for scientists to exploit comparative genomics approaches to understand genome to phenome relationships. In addition, the activities of the G2PN will provide training for undergraduates, graduate students and post-doctoral fellows in the science of comparative biology and genome to phenome relationships. Participation of researchers from universities and colleges serving historically underrepresented groups will be particularly encouraged. The G2PN will also generate educational modules to further enhance student training in G2P concepts. All of the resources developed by the G2PN will be freely available to the scientific community, communicated at scientific meetings, and published in peer-reviewed journals.A major objective of the G2PN will be to encourage researchers to leave their silos and develop collaborative teams that will exploit comparative approaches to enhance our understanding of genome to phenome relationships. The G2PN RCN goals include: Establishing an international G2PN with scientists studying a diverse range of animals; G2PN activities that will directly foster the development of comparative studies by promoting standardization of experimental approaches, data and metadata collection and bioinformatic analyses; promoting new collaborations and proposals among scientists from different specialties through international meetings, web sites, publications and social media; and promoting understanding of comparative genomic studies through the development of training modules using diverse educational modalities. Ultimately, this RCN will improve our understanding of the relationships between selective pressures, genomic changes and phenotypic outcomes. The standards developed by this RCN will find applicability far beyond the science directly affected by the G2P network. These standards will facilitate laboratory work and data comparability across a broad range of species and studies.

了解生物体的DNA（基因组）与基因组表达（现象）导致的表型特征的关系之间的关系是生物学的核心挑战。 来自多种物种的高吞吐量测序和表型数据为基因组与现象数据的比较分析提供了机会。该奖项的目的是开发现象网络（G2PN）研究合作网络（RCN）的基因组，旨在促进脊椎动物和无脊椎动物的比较分析，以丰富我们对基因组与现象之间关系的理解。 G2PN将使用各种实验方法将基因组汇集在一起​​，以了解基因组最终如何表现出现象。 G2PN将为科学家提供必要的工具，以利用比较基因组学方法来理解基因组与现象关系。此外，G2PN的活动将在比较生物学和基因组与现象关系的科学中为大学生，研究生和博士后研究员提供培训。将特别鼓励来自历史上代表性不足的群体的大学和大学的研究人员的参与。 G2PN还将生成教育模块，以进一步增强G2P概念的学生培训。 G2PN开发的所有资源都将免费提供给科学界，在科学会议上进行沟通，并在同行评审的期刊上发表。G2PN的主要目标是鼓励研究人员离开他们的孤岛和开发协作团队，以利用对比较的方法来增强我们对基因对基因组的了解。 G2PN RCN的目标包括：建立一个国际G2PN的科学家研究各种动物； G2PN的活动将通过促进实验方法，数据和元数据收集和生物信息学分析来直接促进比较研究的发展；通过国际会议，网站，出版物和社交媒体来促进不同专业的科学家之间的新合作和建议；并通过使用各种教育方式开发培训模块来促进对比较基因组研究的理解。最终，这种RCN将提高我们对选择性压力，基因组变化和表型结果之间关系的理解。 该RCN制定的标准将发现适用性远远超出了直接受G2P网络影响的科学。这些标准将促进各种物种和研究的实验室工作和数据可比性。