Collaborative Research: Dynamics and Self-Assembly in Block Copolymer Micelles for Tailored Cargo Delivery

合作研究：用于定制货物运输的嵌段共聚物胶束的动力学和自组装

• 批准号: 1437831
• 负责人: Megan Robertson
• 金额: $ 16.51万
• 依托单位: University of Houston
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2018-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1437831&HistoricalAwards=false
• 关键词: Collaborative; Research; Dynamics; Self; Assembly

CBET 1437831/1437767Micelles are tiny self-assembled capsules that can be customized for a variety of technological applications, including carrying drug molecules to a specific location inside the body as well as cleaning up environmental spills. Micelles can be composed of molecules made of two kinds of linked polymer chains, called block copolymers. Micelle behaviors can be finely tuned by changing the molecular structure of the block copolymers, and thus purposely designing the uptake amounts and release rates of interior compounds (such as drugs). This collaborative project explores the structure of block copolymer micelles as well as the block copolymer motions. By combining advanced analysis methods, the investigators will determine how the micelle-encapsulated compounds affect micelle structure and motions, and the exchange of compounds between micelles and their surroundings. This information will help scientists and engineers precisely formulate micelles for new applications in drug delivery, advanced lubrication, oil extraction, personal care products and other industries.This project aims to systematically examine the effects of small molecule additives, co-solvents, and encapsulated drug molecules, on the structure and dynamics of block copolymer micelles. Targeted model additives (tetrahydrofuran and doxorubicin) will be employed to uncover the influence of such additives on micelle structure and dynamics. Small angle neutron scattering and multi-modal nuclear magnetic resonance will be used to investigate the effects of additive-polymer interactions on micelle equilibrium structure, polymer chain and micelle dynamics, and release rates of encapsulated compounds. The combination of these techniques will provide a comprehensive picture of key micellar dimensions and highly specific dynamical information including free unimer exchange kinetics, block and polymer chain dynamics, micelle diffusion processes, detailed solvent dynamics and exchange of additives in and out of micelles, and rates of fission and fusion.

CBET 1437831/1437767Micelles是微小的自组装胶囊，可以针对各种技术应用进行定制，包括将药物分子携带到人体内部的特定位置以及清理环境溢出。 胶束可以由由两种连接的聚合物链组成的分子组成，称为块共聚物。胶束行为可以通过更改块共聚物的分子结构来细微调节，从而有目的地设计内化合物的摄取量和释放速率（例如药物）。 这个协作项目探讨了块共聚物胶束的结构以及块共聚物运动。通过结合高级分析方法，研究人员将确定胶束包裹的化合物如何影响胶束结构和运动，以及胶束及其周围环境之间的化合物的交换。 该信息将帮助科学家和工程师精确地为药物输送，高级润滑，油提取，个人护理产品和其他行业的新应用制定胶束。本项目旨在系统地研究小分子添加剂，共溶剂和包裹的药物分子，对块状共聚物的结构和动力学的影响。 靶向模型添加剂（四氢呋喃和阿霉素）将用于揭示此类添加剂对胶束结构和动力学的影响。 小角度中子散射和多模式的核磁共振将用于研究添加节聚合物相互作用对胶束平衡结构，聚合物链和胶束动力学的影响，以及封装化合物的释放速率。 这些技术的组合将为关键胶束维度和高度特定的动力学信息提供全面的图景，包括免费的单聚合物交换动力学，块和聚合物链动力学，胶束扩散过程，详细的溶剂动力学以及胶束中添加剂的添加剂以及胶束中的添加剂的交换，以及酸味和酸味和融化的速度和融化和融化。