EAGER: NanoEHS Critical Needs - Determining Surface Composition in Biological Media and the Roles of Core Composition and Very Small Particles

EAGER：NanoEHS 关键需求 - 确定生物介质中的表面成分以及核心成分和非常小的颗粒的作用

• 批准号: 1424502
• 负责人: Vicki Grassian
• 金额: $ 10万
• 依托单位: University of Iowa
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1424502&HistoricalAwards=false
• 关键词: EAGER; NanoEHS; Critical; Needs; Determining

AbstractCBET - 1424502Vicki H. GrassianOverview:The challenges in understanding the environmental health and safety of nanomaterials (NanoEHS)are many but several fundamental issues in particular remain critical from a scientific perspective.In fact, it has become apparent that progress will be limited without studies to address these issues.Intellectual Merit:This EAGER proposal will address several critical needs in a concentrated program with specific objectives, hypotheses and goals. These critical areas include:1. The nature of the surface of nanomaterials in biological media2. The role of the core in surface functionalized nanoparticles3. The unique behavior imparted to very small nanoparticles that is not just due to physical size but instead due to quantum and other intrinsic size dependent electronic effects.A series of targeted experiments are proposed to address these needs. These experiments are feasible and will provide the necessary results to define a framework to address the issues discussed in this proposal. In these experiments, nanoparticles will be covered using different surface functionalities including proteins. We will conduct these studies in different media relevant to understanding the toxicity of these particles, i.e. several simulated biological media of different pH to reflect both stomach and lung fluids. Furthermore, we can quantify the amount of dissolution and ROS production in each of these and as a function of particlesize, within a size range where quantum confinement is important and outside of that size range where bulk properties of electronic state structure, e.g. the band gap, are relevant.Broader Impacts:There are several broader impacts and translational aspects of the proposed research. First, the proposed studies are designed to gain better insight into the environmental and health impacts of nanomaterials. These studies will contribute to the growing database on the potential environmental and health implications of nanoscience and nanotechnology. This society relevant research is designed to address potential environmental problems for the nanotechnology industry. Therefore overall it has the potential to provide for the greater good of the public and consumers. The proposed activities provide an opportunity to train students in a highly interdisciplinary research area that involves environmental science and engineering, chemistry, nanoscience, colloid and surface chemistry. The PI has a track record of successfully mentoring students at all levels from high school to postdoctoral associates and visiting research scientists and will continue this effort to mentor the next generation of scientists and engineers. Many of the students are from underrepresented groups in science and engineering including a large percentage of women (more than 60%) and minorities including students on free and reduced lunch programs and typically more diverse student populations. Funds from this NSFgrant will be used to train graduate and undergraduate students to better engage these elementary students as well as the public in science and engineering.

AbstractCbet -1424502Vicki H. Grassianoverview：理解纳米材料的环境健康和安全的挑战（Nanoehs）很多，但尤其是一些基本问题仍然至关重要目标。这些关键领域包括：1。生物培养基中纳米材料表面的性质2。核心在表面功能化纳米颗粒中的作用3。赋予非常小的纳米颗粒的独特行为不仅是由于物理大小引起的，还归因于量子和其他固有大小依赖性电子效应。提出了一系列目标实验来满足这些需求。这些实验是可行的，将提供必要的结果来定义一个框架，以解决本提案中讨论的问题。在这些实验中，纳米颗粒将使用包括蛋白质在内的不同表面功能覆盖。我们将在不同的培养基中进行这些研究，以了解这些颗粒的毒性，即不同pH的几种模拟生物学培养基，以反映胃和肺液。此外，我们可以量化量子限制很重要的大小范围内的尺寸范围内，并且在这些尺寸范围之外量化了每个大小范围，在这些尺寸范围内，在这些尺寸范围内，在这些尺寸范围之内，我们可以量化溶解和ROS的产生量。乐队差距是相关的。公民影响：拟议的研究有一些更广泛的影响和翻译方面。首先，拟议的研究旨在更好地了解纳米材料的环境和健康影响。这些研究将有助于纳米科学和纳米技术的潜在环境和健康影响的增长数据库。该社会相关的研究旨在解决纳米技术行业的潜在环境问题。因此，总体而言，它有可能为公众和消费者提供更大的利益。拟议的活动为培训高度跨学科研究领域的学生提供了机会，该研究领域涉及环境科学和工程，化学，纳米科学，胶体和表面化学。 PI具有成功指导从高中到博士后员工和访问研究科学家的各个级别的学生的记录，并将继续这项努力来指导下一代科学家和工程师。 许多学生来自科学和工程领域的代表性不足的群体，包括很大一部分女性（超过60％）和包括免费和减少午餐计划的学生，以及通常更多样化的学生人数。 NSFGrant的资金将用于培训毕业生和本科生，以更好地吸引这些小学生以及公众的科学和工程学。