Investigating the Interactions of Ions with Polypeptides

研究离子与多肽的相互作用

• 批准号: 1413307
• 负责人: Paul Cremer
• 金额: $ 47.51万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1413307&HistoricalAwards=false
• 关键词: Investigating; Interactions; Ions; Polypeptides

With support from the Macromolecular, Supramolecular, and Nanochemistry program of the Chemistry Division, Professor Paul S. Cremer at the Pennsylvania State University is exploring the roles that ions play in aqueous solutions containing organic molecules and polymers. Such research can have broad impact as ions influence an enormous variety of processes from allowing molecules to clump together or aggregate, to catalyze processes in cells, and even the length of time it takes to pickle a cucumber. Understanding the pathways that enable proteins to aggregate into particular structures may help reveal the nature of certain human diseases. The behavior of the solutions will be used to create simple demonstration devices as part of an educational outreach effort.Cations and anions in aqueous solvent may interact with each other or with charged groups on small molecules, Langmuir monolayers, and polymer chains. A variety of spectroscopies including infrared, Raman, and vibrational sum frequency generation will be used to investigate how contact pair, solvent shared, and solvent separated ion-ion interactions are affected by the size of the ions, their geometry, their hydrogen bonding ability, van der Waals forces, and the surrounding chemical environment. The molecular level details of these interactions will then be correlated with thermodynamic properties of the corresponding aqueous solutions to understand how ion pairing can influence macroscopic behavior.

在化学部的大分子，超分子和纳米化学计划的支持下，宾夕法尼亚州立大学的Paul S. Cremer教授正在探索离子在含有有机分子和聚合物的水溶液中发挥的作用。这种研究可能会产生广泛的影响，因为离子会影响从允许分子团结或聚集，到催化细胞中的过程，甚至腌制黄瓜所需的时间的大量过程。了解使蛋白质能够汇总成特定结构的途径可能有助于揭示某些人类疾病的本质。解决方案的行为将用于创建简单的演示设备，作为教育外展工作的一部分。水溶液中的阳离子和阴离子可以彼此相互作用，也可以与小分子，Langmuir单层和聚合物链上的带电组相互作用。包括红外，拉曼和振动总和频率产生在内的多种光谱学将用于研究接触对，溶剂共享和溶剂分离的离子离子相互作用如何受离子的大小，其几何形状，其氢键，范德尔·瓦尔斯力，范德瓦尔斯力和周围化学环境的影响。然后，这些相互作用的分子水平细节将与相应水溶液的热力学特性相关，以了解离子配对如何影响宏观行为。