DISSERTATION RESEARCH: The Genetic Architecture of Covarying Traits

论文研究：共变性状的遗传结构

• 批准号: 1406805
• 负责人: Thomas Mitchell-Olds
• 金额: $ 2.04万
• 依托单位: Duke University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-08-01 至 2017-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1406805&HistoricalAwards=false
• 关键词: DISSERTATION; RESEARCH; Genetic; Architecture; Covarying

The capacity of organisms to respond to selective pressures on multiple traits is determined in part by the genetic covariances between those traits. This project will map regions of the genome associated with genetic variation in glucosinolate traits in a population of Boechera stricta, a model plant for evolutionary genetics. B. stricta makes several types of glucosinolates, compounds that defend the plant against insect herbivores. By mapping the regions of the genome that control glucosinolate profile in each type of plant tissue, the investigator will determine whether the same or different loci control glucosinolates throughout the plant. Then, using population data at these genomic regions, the amount of covariation in glucosinolate traits controlled by each locus will be determined. Knowing the genetic architecture of covarying traits is essential in predicting how those traits are able to respond to selection; if one gene controls multiple traits, evolutionary constraints are likely to be stronger than if trait correlations are caused by correlated selective pressures. Genetic covariances have been important to plant breeders, as well, as they may affect the response to artificial selection. Understanding the genetic basis of glucosinolate allocation, which is agriculturally relevant and affects cancer risk in humans, will lend insight into how breeding programs may affect crop plants. This grant will also support training of a young scientist in important genomic techniques and analyses, as well as outreach efforts in traditionally underperforming schools encouraging students, particularly girls, to pursue college and a career in the STEM fields.

生物体对多种特征的选择性压力做出反应的能力部分取决于这些特征之间的遗传协方差。该项目将绘制与Boechera Stricta群体中葡萄糖苷特性状的遗传变异相关的基因组区域，Boechera Stricta是一种用于进化遗传学的模型植物。 B. stricta生产几种类型的葡萄糖醇酸盐，可以防御昆虫食草动物的化合物。通过绘制控制每种类型的植物组织中葡萄糖苷酸化谱的基因组区域，研究者将确定整个植物中相同或不同的基因座对照葡萄糖醇。然后，使用这些基因组区域的人群数据，将确定由每个基因座控制的葡萄糖苷特征的协方差量。了解协方格特征的遗传结构对于预测这些特征如何对选择的反应至关重要。如果一个基因控制多种性状，那么进化约束可能比特征相关性是由相关的选择压力引起的。遗传协方差对植物育种者也很重要，因为它们可能会影响对人工选择的反应。了解与农业相关的葡萄糖苷分配的遗传基础，并影响人类的癌症风险，将洞悉繁殖计划如何影响作物植物。该赠款还将支持对重要基因组技术和分析的年轻科学家的培训，以及传统上表现不佳的学校的宣传工作，鼓励学生，尤其是女孩，攻读大学和在STEM领域的职业。