Molecular Quantitative Genetics of Inbreeding Depression and Hybrid Breakdown in Arabidopsis

拟南芥近交衰退和杂种崩溃的分子定量遗传学

• 批准号: 9307747
• 负责人: Thomas Mitchell-Olds
• 金额: $ 26.5万
• 依托单位: University of Montana
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1997-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9307747&HistoricalAwards=false
• 关键词: Molecular; Quantitative; Genetics; Inbreeding; Depression

9307747 Mitchell Olds Molecular Biological approaches to quantitative genetics can be used to study in breeding depression and hybrid breakdown. The genetic basis of inbreeding dpression is an unanswered question with implications for many problems in agriculture and genetics. For example, hybrid vigor (avoidance of inbreeding depression) is responsible for a large portion of the increases in crop yield obtained by plant breeders. Crosses between distantly related populations may produce offspring with reduces fitness (hybrid breakdown). Phenotypic plasticity and genotype environment interaction may also be important in agricultural and wild species. Despite many years of inquiry, the genetic basis of these phenomena remains unclear. %%% Using recently developed techniquesin molecular biology it is now feasible to elucidate the genetic basis of ombreeding depression and outbreeding depression. This technology will be used to ask 1) What causes hybrid vigor? 2) Does genotype environment interaction contribute to hybrid vigor? 3) How do changes in gene expression cause genotype environment interaction? 4) What causes hybrid breakdown? This research will have important implications for understanding the genetics of agricultural and natural populations.

9307747 Mitchell Olds分子生物学方法用于定量遗传学，可用于研究繁殖抑郁症和杂种分解。 近亲繁殖的遗传基础是一个未回答的问题，对农业和遗传学中的许多问题产生了影响。 例如，杂种活力（避免近交抑郁症）是造成植物育种者获得的作物产量增加的很大一部分。 远距离相关人群之间的交叉可能会产生降低健身的后代（混合分解）。 表型可塑性和基因型环境相互作用在农业和野生物种中也可能很重要。 尽管进行了多年的询问，但这些现象的遗传基础尚不清楚。 %% %%使用最近开发的技术分子生物学，现在可以阐明抑郁症和抑郁症的遗传基础是可行的。 这项技术将用于询问1）什么引起混合活力？ 2）基因型环境相互作用是否有助于混合活力？ 3）基因表达的变化如何引起基因型环境相互作用？ 4）是什么原因导致混合分解？ 这项研究将对理解农业和自然种群的遗传学具有重要意义。