Molecular Quantitative Genetics of Inbreeding Depression and Hybrid Breakdown in Arabidopsis

拟南芥近交衰退和杂种崩溃的分子定量遗传学

• 批准号: 9307747
• 负责人: Thomas Mitchell-Olds
• 金额: $ 26.5万
• 依托单位: University of Montana
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1993
• 资助国家: 美国
• 起止时间: 1993-08-01 至 1997-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9307747&HistoricalAwards=false
• 关键词: Molecular; Quantitative; Genetics; Inbreeding; Depression

9307747 Mitchell Olds Molecular Biological approaches to quantitative genetics can be used to study in breeding depression and hybrid breakdown. The genetic basis of inbreeding dpression is an unanswered question with implications for many problems in agriculture and genetics. For example, hybrid vigor (avoidance of inbreeding depression) is responsible for a large portion of the increases in crop yield obtained by plant breeders. Crosses between distantly related populations may produce offspring with reduces fitness (hybrid breakdown). Phenotypic plasticity and genotype environment interaction may also be important in agricultural and wild species. Despite many years of inquiry, the genetic basis of these phenomena remains unclear. %%% Using recently developed techniquesin molecular biology it is now feasible to elucidate the genetic basis of ombreeding depression and outbreeding depression. This technology will be used to ask 1) What causes hybrid vigor? 2) Does genotype environment interaction contribute to hybrid vigor? 3) How do changes in gene expression cause genotype environment interaction? 4) What causes hybrid breakdown? This research will have important implications for understanding the genetics of agricultural and natural populations.

9307747 Mitchell Olds 定量遗传学的分子生物学方法可用于研究繁殖衰退和杂交崩溃。 近交抑制的遗传基础是一个悬而未决的问题，对农业和遗传学中的许多问题都有影响。 例如，杂种活力（避免近交衰退）是植物育种者获得的作物产量增加的很大一部分原因。 远缘种群之间的杂交可能会产生适应性降低的后代（杂交崩溃）。 表型可塑性和基因型环境相互作用对于农业和野生物种也可能很重要。 尽管经过多年的研究，这些现象的遗传基础仍不清楚。 %%% 利用最近开发的分子生物学技术，现在可以阐明近交衰退和远交衰退的遗传基础。 该技术将用于询问：1）是什么导致了混合动力？ 2）基因型环境相互作用是否有助于杂种活力？ 3）基因表达的变化如何引起基因型环境相互作用？ 4）什么原因导致混合故障？ 这项研究将对了解农业和自然种群的遗传学产生重要影响。