Fabrication of Novel Core-Shell Nanocomposites as Targeted Carriers

新型核壳纳米复合材料作为靶向载体的制备

• 批准号: DP160103497
• 负责人: A/Prof Porun Liu
• 金额: $ 20.49万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-04-01
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160103497
• 关键词: Fabrication; Novel; Core; Shell; Nanocomposites

This project intends to design and fabricate a group of core-shell nanocomposites as new-generation carriers for effective drug delivery applications. The unique core-shell functional materials possess radiation/magnetic-responsive release behaviour due to the nanoparticle core, and good biocompatibility, ultra-high loading capacity and outstanding targeting specificity due to the surface-modified mesoporous metal-organic frameworks shell. Development of such hybrid materials would overcome the existing challenges such as low loading capacity, poor release control. The application of such materials may help to improve the efficacy of pharmaceutical therapies.

该项目旨在设计和制造一组核壳纳米复合材料作为有效药物输送应用的新一代载体。独特的核壳功能材料由于纳米颗粒核而具有辐射/磁响应释放行为，由于表面改性介孔金属有机框架壳而具有良好的生物相容性、超高负载能力和突出的靶向特异性。这种混合材料的开发将克服现有的挑战，例如负载能力低、释放控制差。此类材料的应用可能有助于提高药物治疗的功效。