Core D: Behavioral Phenotyping Core

核心 D：行为表型核心

基本信息

批准号：
10686039
负责人：
Fiona Edith Harrison
金额：
$ 22.54万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-06 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10686039
关键词：
Acceleration Address Adopted Affect Animal Model Animal Testing Animals Area Articulation Basic Science Behavior assessment Behavioral Caregivers Clinical Clinical assessments Communities Complement Complex Computer software Consultations Data Data Analyses Data Collection Data Science Core Development Disease Down Syndrome Encapsulated Equipment Experimental Designs Family Fee-for-Service Plans Funding Generations Goals Grant Home Human Individual Infrastructure Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Intervention Laboratories Language Manuscripts Measurement Measures Methods Modeling Outcome Output Persons Phenotype Physiological Population Precision therapeutics Protocols documentation Quality of life Reproducibility Research Research Personnel Research Training Resources Rodent Rodent Model Services Testing Training Translating Translational Research Vulnerable Populations Work animal data autism spectrum disorder behavior observation behavioral phenotyping community involvement data integration design disability experience fabrication home test human data human model improved individualized medicine innovation instrumentation investigator training laboratory experience large datasets mouse model new technology non-verbal novel novel strategies phenotypic data pre-clinical predictive marker public health relevance response success targeted treatment testing services tool translational barrier translational neuroscience wearable device

项目摘要

The Behavioral Phenotyping Core (Core D) is designed to support three overarching aims: To support and promote innovative and replicable behavioral phenotyping data in clinical populations people with IDD (Aim 1) and in rodent models of IDD (Aim 2); and to facilitate translational research incorporating human and animal data approaches (Aim 3). Previously supported iterations of this Core have been highly generative in terms of grant submission and manuscript support. The guiding thematic focus of the newly designed Core supports the “non-traditional” emphasis articulated for the overarching goals of the IDDRC in incorporating non-traditional researchers, non-traditional populations, and non-traditional approaches into every facet of the core. The Core will accomplish these goals by providing six major services: (i) Consultation. The three Co-Directors (Peters, Harrison, Wallace) have complementary expertise in human and animal phenotyping including specific experience with project design and analysis approaches. Consultation services will serve to support rigorous experimental design by IDD researchers and, importantly, support non-IDD researchers who wish to develop IDD-relevant projects despite lack of previous experience (non-traditional researchers). Consultation services are supported by comprehensive (ii) training for Core users. Training includes hands-on support for equipment use (animal and human research) and clinical assessment training. A new focus of the Core is to support the use of wearable devices and the use of apps for in-home behavioral observation in order to provide the opportunity for non-traditional populations to participate in research. Training will therefore also extend to non-scientist care-givers for in-home testing. Key to the Core’s success in prior funding periods has been the ability to provide (iii) access to equipment and facilities. State-of-the-art facilities and equipment for human and animal testing will continue to be supported for IDD researchers to use on a discounted fee-for-service basis. (iv) Full-service phenotyping is now offered for both human and animal testing conducted by trained research technicians. This service will permit non-traditional researchers to perform IDD-related research regardless of IDD-related experience, increase testing throughput, particularly for smaller laboratories, and support experimental rigor. The Core will continue to offer (v) scientific Instrumentation fabrication services for specialized equipment for human and animal projects. The final service (vi) data integration and conceptual development is designed as a complement to consultation service for basic science investigators who wish expand their work into human clinical populations, as well as for clinically-oriented investigators wishing to expand into animal models. This truly translational service will enable similar methods and models to be utilized or adapted across species to directly measure phenotypically relevant outcomes including behavioral and physiological measures, therefore encapsulating the IDDRC’s overarching goal to accelerate discovery in IDD research through trans-disciplinary approaches.

行为表型核心 (Core D) 旨在支持三个总体目标：支持和促进 IDD 临床人群的创新和可复制的行为表型数据（目标 1）以及 IDD 啮齿动物模型（目标 2），并促进人类和动物的转化研究；数据方法（目标 3）之前支持的该核心迭代在以下方面具有很高的生成性。新设计的核心的指导主题重点支持资助提交和稿件支持。强调“非传统”，以实现 IDDRC 纳入非传统的总体目标研究人员、非传统人群和非传统方法深入核心的各个方面。将通过提供六项主要服务来实现这些目标： (i) 三位联合董事（Peters、Peters）。 Harrison、Wallace）在人类和动物表型分析方面拥有互补的专业知识，包括特定的项目设计和分析方法方面的经验将有助于支持严格的要求。 IDD 研究人员进行实验设计，重要的是，支持希望开发的非 IDD 研究人员尽管缺乏经验（非传统研究人员咨询服务），但仍开展 IDD 相关项目。得到针对核心用户的全面 (ii) 培训的支持培训包括对核心用户的实践支持。设备使用（动物和人类研究）和临床评估培训的新重点是。支持使用可穿戴设备和使用应用程序进行家庭行为观察，以提供因此，非传统人群参与研究的机会也将扩大。核心在之前的资助期间取得成功的关键是非科学家护理人员进行家庭测试。 (iii) 为人类提供最先进的设施和设备的能力。 IDD 研究人员将继续支持动物测试，以享受折扣服务费 (iv) 现在提供由经过培训的人员进行的人体和动物测试的全方位表型分析服务研究技术人员。这项服务将允许非传统研究人员进行 IDD 相关研究。无论 IDD 相关经验如何，提高测试吞吐量，特别是对于小型实验室而言，以及支持实验的严谨性。The Core 将继续提供 (v) 科学仪器制造服务。用于人类和动物项目的专用设备最终服务 (vi) 数据集成和概念开发旨在作为基础科学研究人员咨询服务的补充希望将工作扩展到人类临床人群以及面向临床的研究人员希望扩展到动物模型，这种真正的转化服务将实现类似的方法和模型。可在物种之间使用或适应，以直接测量表型相关的结果，包括行为和生理测量，因此概括了 IDDRC 的总体目标，即加速通过跨学科方法进行 IDD 研究发现。