Organometallic Chemistry of Heterocycles

杂环有机金属化学

基本信息

批准号：
1360985
负责人：
William Jones
金额：
$ 42万
依托单位：
University of Rochester
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-01 至 2018-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1360985&HistoricalAwards=false
关键词：
Organometallic Chemistry Heterocycles

项目摘要

In this project funded by the Chemical Catalysis program of the Chemistry Division, Professor William Jones of the University of Rochester is examining new reactions that can be used to make organic compounds of interest in biology and the pharmaceutical industry. To accomplish this, fundamental reactions of transition metal catalysts are being examined that can be used to form heterocycles from readily available, inexpensive starting materials. Professor Jones is also examining new catalysts that can break open heterocycles and allow their structures to be altered.The broader impacts of this work include outreach to high school students to attract interest to careers in STEM related fields, as well as the development of new processes for routes to intermediates of pharmaceutical importance. The combination of a detailed physical-organometallic background combined with an understanding of how to apply modern computational methods to these problems produces extremely well trained scientists for the US chemical industry. One specific goal of this project is to examine fundamental aspects of cyclometallation via the "Concerted Metallation-Deprotonation" pathway that is now popular in organic synthetic methodology to produce heterocycles. These cyclometallation studies are revealing fundamental aspects of how these molecules effect the chemical transformations, and are providing insight into the control of the selectivity that is critical to formation of the desired product. A second goal is to develop uses for the now commonly observed transition metal based carbon-sulfur bond cleavage sulfur-containing molecules. One application involves anchoring a reversible carbon-sulfur activation catalyst to a solid support that allows this material to act as a "sulfur sponge," thereby permitting the cleanup of hydrocarbon fuels prior to combustion.

在该项目由化学部化学催化计划资助的项目中，罗切斯特大学的威廉·琼斯（William Jones）教授正在研究新反应，这些反应可用于使生物学和制药行业具有兴趣的有机化合物。为此，正在检查过渡金属催化剂的基本反应，可用于从容易获得的廉价起始材料中形成异环。琼斯教授还正在研究可以打破开放杂种并允许其结构改变的新催化剂。这项工作的更广泛影响包括向高中生推广，以吸引与STEM相关领域的职业以及新流程的发展的兴趣对于具有药物重要性中间的路线。详细的物理和金属金属的背景结合结合了如何将现代计算方法应用于这些问题的理解，为美国化学工业提供了训练有素的科学家。该项目的一个具体目标是通过“协同的金属 - 剥离式”途径来检查环定测量的基本方面，该途径现在在有机合成方法中很流行，以产生杂环。这些环定研究研究揭示了这些分子如何影响化学转化的基本方面，并提供了对选择性对所需产物形成至关重要的选择性的洞察力。第二个目标是开发目前通常观察到的过渡金属碳硫键裂解分子的用途。一种应用涉及将可逆的碳硫激活催化剂锚定给固体支持，该材料可以用作“硫海绵”，从而可以在燃烧之前清理碳氢化合物燃料。