The effect of testosterone pulses and conditioned place preferences on social behavior in wild and laboratory Peromyscus mice

睾酮脉冲和条件性位置偏好对野生和实验室白鼠社交行为的影响

基本信息

批准号：
1355163
负责人：
Catherine Marler
金额：
$ 78万
依托单位：
University of Wisconsin-Madison
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2014
资助国家：
美国
起止时间：
2014-06-15 至 2018-12-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1355163&HistoricalAwards=false
关键词：
effect testosterone pulses conditioned place

项目摘要

When an individual animal interacts with another individual, it has a physiological response. The researchers are trying to understand how physiological responses can influence current and future behavior. Other studies have shown that hormones, such as testosterone, can increase after a social interaction. An important question is whether this hormone release can influence future behavior. Because some hormones can result in a positive, rewarding response, a preference for a location can form in response to the release of a hormone such as testosterone. Thus, any male-male or male-female interaction that results in the release of testosterone may induce an individual to seek out that location repeatedly. Hormone release may therefore influence how individuals use space through the development of preferences for specific locations. This research investigates, for the first time, the natural function of the reward-like properties of testosterone related to the development of preferences for specific locations. This research may reveal a new mechanism, testosterone pulses, for responding rapidly to adapt to changing social conditions associated with specific locations.The researchers use conditioned place preference development in response to testosterone injections to provide insight into the mechanisms balancing the different social demands of a monogamous and territorial species, the biparental California mouse. The hypothesis is that testosterone pulses induce spatial distributions appropriate for the social demands of the environment and, in turn, alter context appropriate behaviors in the form of paternal and territorial behavior, pair bond maintenance, mate advertisement and mate-attendance. The testosterone-induced spatial distribution may influence behavior only through location or may further amplify and alter social interactions. Within this framework, the researchers test questions in both simple and complex environments. They examine complex aspects of testosterone-modified social interactions by assessing acoustic communication in the field and laboratory. The researchers propose to examine three aims to address the function of T pulses and resulting effects on conditioned place preferences and social behavior for focal pair-bonded males and their mates (Aim 1a), focal male interactions with pups (Aim 1b), focal male interactions with a female intruder (Aim 2), and focal male interactions with a male intruder (Aim 3). This research will create a stimulating and collaborative student-training environment with unique experiences that integrate behavioral endocrinology studies in the field and laboratory. The collaboration between a midwestern R1 and small southern research institution with fieldwork conducted at the Hastings Natural History Reserve in California, will facilitate wide dissemination of expertise across researchers and students, including STEM URM students. The project will be integrated with a successful 10-year old outreach program called "Bats and Mice in Your Backyard." Two software packages are being developed to automate the analysis of ultrasonic vocalizations and mouse behavior from thermal videos collected in the field and will be made available under an open source license

当单个动物与另一个人相互作用时，它会有生理反应。研究人员试图了解生理反应如何影响当前和未来的行为。其他研究表明，社交互动后的激素（例如睾丸激素）可以增加。一个重要的问题是，这种激素释放是否会影响未来的行为。由于某些激素可以产生积极的，有益的反应，因此偏爱位置可以响应激素（例如睾丸激素）的释放而形成。因此，任何导致睾丸激素释放的男性或男女相互作用都可能诱使一个人反复寻找该位置。因此，激素释放可能会影响个人如何通过发展特定位置的偏好来使用空间。这项研究首次研究了与特定位置偏好发展有关的睾丸激素的奖励样性能的自然功能。这项研究可能揭示了一种新的机制，即睾丸激素脉冲，以迅速响应以适应与特定位置相关的不断变化的社会条件。研究人员使用条件的位置偏好开发来响应睾丸激素注射，以洞悉平衡单一和领土物种的不同社会需求的机制。假设是，睾丸激素脉冲会诱导适合环境社会需求的空间分布，进而改变背景行为，以父亲和领土行为的形式，配对债券维护，伴侣广告和伴侣与符号的形式。睾丸激素诱导的空间分布只能通过位置影响行为，或者可能进一步扩大和改变社交相互作用。在此框架内，研究人员在简单和复杂的环境中都测试了问题。他们通过评估现场和实验室的声学交流来检查睾丸激素改造的社会互动的复杂方面。研究人员建议研究三个目标，以解决T脉冲的功能，并对有条件的位置偏好和社会行为产生影响，对焦点成对的男性及其伴侣及其伴侣（AIM 1A）（AIM 1A），与幼崽的焦点相互作用（AIM 1B），焦点男性与女性入侵者的互动（AIM 2）以及与男性的互动（AIM 2）以及与男性与男性的互动相互作用。这项研究将创造一个刺激性和协作的学生培训环境，并具有将行为内分泌学研究整合到现场和实验室中的独特经验。中西部R1与南部研究机构与在加利福尼亚的Hastings自然历史保护区进行的实地调查之间的合作将有助于在包括STEM URM学生在内的研究人员和学生之间广泛传播专业知识。该项目将与成功的10年历史外展计划集成，称为“后院的蝙蝠和老鼠”。正在开发两个软件包，以自动对现场收集的热视频的超声声音和鼠标行为进行分析，并将根据开源许可提供