CAREER: New Metal Catalyzed Reactions for Trans-Alkynevinylation

职业生涯：新金属催化的反炔乙烯基化反应

• 批准号: 1352432
• 负责人: Daniel Clark
• 金额: $ 65万
• 依托单位: Syracuse University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-01-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1352432&HistoricalAwards=false
• 关键词: CAREER; New; Metal; Catalyzed; Reactions

With this CAREER Award, the Chemical Catalysis Program supports the research of Professor Daniel A. Clark of the Department of Chemistry at Syracuse University. Professor Clark develops new catalytic methods for the silylvinylation of alkynes. The first objective of this research is to utilize ethylene, an abundant chemical feedstock, as a coupling partner to produce highly substituted cyclic compounds that contain a diene. The role of ethylene on the stereochemical outcome of silylvinylation of alkynes is carefully examined. The second objective explores the use of vinylboronates as coupling partners with alkynes to create more complex systems. This approach is likely to eliminate waste streams as no pre-functionalization of starting materials is required. The successful implementation of the proposed research is expected to positively impact the fields of organic chemistry and agrochemistry, pharmaceuticals, and the materials industry. The CAREER award also provides support for educational programs; specifically, the creation of workshops for Science, Technology, Engineering, and Mathematics (STEM) educators in the Syracuse and North Syracuse public schools. The goal of Professor Clark's program is to offer access to lecture materials and chemical experiments that can be implemented in a classroom environment by K-12 teachers. Professor Clark's program is in line with the vision of Syracuse University (SU) entitled: Scholarship in Action, a commitment from SU to sustained community engagement.

通过此职业奖，化学催化计划支持锡拉丘兹大学化学系的丹尼尔·克拉克教授的研究。 克拉克教授开发了炔烃化的新催化方法。 这项研究的第一个目的是利用乙烯（一种丰富的化学原料）作为耦合伙伴，以产生含有二烯的高度取代的环状化合物。 仔细检查了乙烯在炔烃化的立体化学结果上的作用。 第二个目标探讨了乙烯基硼酸盐作为与炔烃的耦合伙伴以创建更复杂系统的耦合。 这种方法可能会消除废物流，因为不需要对起始材料进行预官能化。 预计拟议研究的成功实施将对有机化学和农业化学，制药和材料行业的领域产生积极影响。 职业奖还为教育计划提供支持；具体而言，在锡拉丘兹和北锡拉丘兹公立学校的科学，技术，工程和数学（STEM）教育者创建研讨会。 克拉克教授计划的目标是提供访问K-12教师可以在课堂环境中实施的讲座材料和化学实验的访问。 克拉克教授的计划与锡拉丘兹大学（SU）的愿景一致，题为“行动中的奖学金：SU到持续社区参与的承诺”。