2022 Metals in Medicine Gordon Research Conference

2022 年戈登医学金属研究会议

• 批准号: 10469045
• 负责人: Edith C Glazer
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10469045
• 关键词: Academia; Address; Area; Basic Science; Bioinorganic Chemistry; Career Mobility; Catalysis; Cells; Chemicals; Chemistry; Clinical; Communities; Complex; Contrast Media; Data; Developing Countries; Development; Diagnosis; Diagnostic; Disease; Early Diagnosis; Ensure; Environment; Etiology; Fertilization; Fostering; Funding; Government; Growth; Health; Hour; Human; Image; Industry; International; Learning; Magnetic Resonance Imaging; Medical; Medicine; Mentors; Metals; Methods; Mission; Modernization; Molecular; Nanotechnology; Oral; Participant; Pathologic; Pharmaceutical Preparations; Positron-Emission Tomography; Postdoctoral Fellow; Process; Property; Proteins; Radioisotopes; Radionuclide therapy; Research; Research Personnel; Role; Science; Scientist; Social Interaction; Stimulus; System; Technology; Therapeutic; Therapeutic Agents; Trace metal; Translating; Translations; United States National Institutes of Health; Visit; Woman; Work; base; career; catalyst; chelation; clinical translation; design; disease diagnosis; experience; graduate student; improved; informal atmosphere; innovation; meetings; metal complex; multidisciplinary; nanomaterials; nanoscale; nanoscience; nanotheranostics; new technology; next generation; novel; personalized medicine; posters; preclinical evaluation; programs; research clinical testing; small molecule; symposium; theranostics; tool

PROJECT SUMMARY/ABSTRACT The mission of the Metals in Medicine Gordon Research Conference (GRC) is to cultivate a community of multidisciplinary scientists focused on improving human health by translating basic science discoveries in the areas of bioinorganic chemistry, materials, and inorganic nanotechnology to medical application. The 2022 Metals in Medicine GRC will bring together more than 150 scientists and clinicians from around the world in academia, industry and government to discuss the latest developments in the field in the intimate and informal environment of a GRC. The organizers have three specific aims: 1) Showcase how the properties intrinsic to metals and inorganic materials can be leveraged to develop transformative new chemical and nano-scale entities for use in the diagnosis, imaging, and treatment of disease; 2) Highlight the development of new systems and optimization of existing technologies to aid in understanding the roles of metals in the pathological basis for disease and medical treatments; 3) Provide a stimulating and dynamic gathering to engage and inspire young scientists in this evolving field. The theme of the 2022 meeting is “Advancing the use of metal-based compounds and nanotheranostics for personalized medicine.” Aim 1 is addressed by emphasizing the unique features of metals to support human health. Several sessions mix basic science with advanced pre-clinical and clinical evaluation. The program opens with Supramolecular Coordination Complexes for Biomedical Applications, which will feature the latest innovations in nanoscience as it relates to self-assembling molecular systems and nanomaterials as theranostics. Novel Chelation Strategies and Applications for Radionuclides and Contrast Agents focuses on stably complexing metals to bioconjugates for diagnostics (PET and MRI), and for targeted radionuclide therapy. There will be two sessions on metal-based therapeutics (Stimuli-responsive Materials for Therapy and Imaging and Targeted Metal-based Therapeutics). Clinical Advances for Metals in Medicine will discuss metal-based diagnostics and therapeutics that are in early human trials. Aim 2 is achieved with sessions focusing on basic research and early development of new technologies. The role of specific metals in the etiology of disease will be presented in the session Essential Metals in Disease Mechanisms, and the emerging area of Catalysis in Cells highlights advances in this traditional application of metals in an untraditional environment. Novel Metallomics Methods and Tools presents approaches and technologies to detect, quantify, and trace metals and inorganic materials. The Early Career Investigators/Emerging Topics session will complete the program, and supports Aim 3, with an emphasis on encourage early career investigators. Speakers will also be selected from the submitted abstracts, achieving 25% representation from early stage scientists and ensuring that the most exciting new discoveries are presented. Other program features focused include “Poster Previews”, the “Power Hour” to address issues around career advancement for STEM women scientists, and many informal activities.

项目摘要/摘要 医学中金属戈登研究会议（GRC）的使命是培养一个社区 多学科科学家致力于通过翻译基础科学发现来改善人类健康 生物无机化学，材料和无机纳米技术的领域。 2022年 医学中的金属GRC将汇集来自世界各地的150多名科学家和临床医生 学术界，工业和政府讨论该领域的最新事态发展 GRC的环境。组织者有三个具体目标：1）展示属性如何固有 可以利用金属和无机材料来开发变革性的新化学和纳米级实体 用于诊断，成像和治疗疾病； 2）突出显示新系统的开发 优化现有技术以帮助理解金属在病理基础上的作用 疾病和医疗治疗； 3）提供刺激和动态的聚会来吸引和激发年轻人 这个不断发展的领域的科学家。 2022年会议的主题是“推进使用金属化合物和纳米固醇的使用 个性化医学。” AIM 1通过强调金属的独特特征来支持人 健康。几个课程将基础科学与先进的临床前和临床评估相结合。该程序打开 具有用于生物医学应用的超分子协调复合物，该复合物将具有最新的 纳米科学的创新与自组装分子系统和纳米材料有关 疗法。新颖的螯合策略和放射线和对比剂的应用集中在 将金属浓缩到生物缀合物中，以进行诊断（PET和MRI），并进行靶向放射线治疗。 基于金属的治疗将有两次会议（刺激性反应材料用于治疗和成像 和靶向金属的治疗剂）。医学金属的临床进展将讨论基于金属的 在早期人类试验中的诊断和疗法。 AIM 2是通过专注于基本的会议来实现的 新技术的研究和早期开发。特定金属在疾病病因中的作用将 在疾病机制中的会议中的必要金属和催化区域中的必要金属 细胞在非传统环境中这种传统的金属应用中强调了进步。小说 金属学方法和工具提出了检测，量化和跟踪金属的方法和技术 无机材料。早期职业调查人员/新兴主题会议将完成该计划，并且 支持目标3，重点是鼓励早期职业调查人员。演讲者也将从 提交的摘要，从早期科学家那里获得25％的代表，并确保最多 提出了令人兴奋的新发现。其他计划功能的重点包括“海报预览”，“电源” 小时”，以解决有关STEM女科学家的职业发展以及许多非正式活动的问题。