EFRI-ODISSEI: Origami and Assembly Techniques for Human-Tissue-Engineering (OATH)

EFRI-ODISSEI：人体组织工程 (OATH) 的折纸和组装技术

• 批准号: 1332249
• 负责人: Carol Livermore
• 金额: $ 200万
• 依托单位: Northeastern University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-08-01 至 2019-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1332249&HistoricalAwards=false
• 关键词: EFRI; ODISSEI; Origami; Assembly; Techniques

The overall research objective of this project is to create assembly- and origami-based techniques for the generation of fully three-dimensional living tissues that are structured like natural tissues and include effective vascular networks. To accomplish this goal, the research first uses two-dimensional directed assembly to selectively locate multiple cell types in their proper locations on two-dimensional scaffold structures. The scaffolds are then origami-folded to convert the two-dimensional cell assemblies into three-dimensional structures that replicate the structure of natural tissues. This research addresses the three limitations to tissue engineering - tissue quality, tissue quantity, and speed of production - that have stood in the way of generating tissues for medical therapies. The project will also create new K-12 teacher training materials on origami in mathematics; involve high school students and teachers directly in the research; enable research opportunities for undergraduates from a diversity of backgrounds; and engage with high school students and the public through museum and high school level mathematics outreach. If successful, this project offers the potential to save lives through the creation of tissues rapidly and efficiently with an extremely high level of control over tissue structure. At present, the limited supply of donor organs leads to thousands of deaths every year. The improved engineering of human tissues has the potential to save lives directly, through the provision of transplants to supplement the supply of donor organs, as well as indirectly, by creating tissues for the screening of new medical therapies before human testing takes place. From an educational and societal perspective, the benefits include enhancement of grade school and high school mathematics education through wide distribution of teacher training materials; increased opportunities for public engagement with origami mathematics through museum exhibits; and broadened research engagement of high school students, undergraduates, and teachers, with a particular emphasis on those from underrepresented minority backgrounds or who serve predominantly underrepresented minority communities. This research project is jointly supported by the National Science Foundation and the US Air Force Office of Scientific Research.

该项目的总体研究目标是创建基于组装和折纸的技术，以产生像天然组织一样结构化的全三维生活组织，并包括有效的血管网络。为了实现这一目标，该研究首先使用二维定向组件在二维脚手架结构上选择性地定位多种细胞类型。然后将脚手架折叠以将二维细胞组件转换为三维结构，以复制自然组织的结构。这项研究解决了组织工程的三个局限性 - 组织质量，组织数量和生产速度，这些局限性以生成医疗疗法的组织的方式。该项目还将创建有关数学折纸的新的K-12教师培训材料；直接让高中生和老师参与研究；为来自各种背景的本科生提供研究机会；并通过博物馆和高中数学宣传与高中生和公众互动。如果成功，该项目将通过快速有效地创建组织，以极高的控制组织对组织结构的控制来挽救生命。目前，捐赠者器官的供应有限每年导致数千人死亡。人体组织的工程改进有可能通过提供移植物来直接挽救生命，以补充供体器官的供应，并间接地通过创建组织来筛查在人类测试之前筛查新的医疗疗法。从教育和社会的角度来看，好处包括通过广泛分配教师培训材料来增强小学和高中数学教育；通过博物馆展览增加了与折纸数学参与的机会；并扩大了高中生，本科生和教师的研究参与，特别着重于代表性不足的少数群体背景或主要服务于代表性不足的少数民族社区的研究。该研究项目得到了国家科学基金会和美国空军科学研究办公室的共同支持。