CAREER: Methodology of Aliphatic Biodegradable Photoluminescent Polymer Development

职业：脂肪族可生物降解光致发光聚合物的开发方法

• 批准号: 1313553
• 负责人: Jian Yang
• 金额: $ 30.86万
• 依托单位: Pennsylvania State Univ University Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1313553&HistoricalAwards=false
• 关键词: CAREER; Methodology; Aliphatic; Biodegradable; Photoluminescent

This Career award by the Biomaterials Program in the Division of Materials Research to the University of Texas Arlington is to design, synthesize, characterize and identify fluorescent mechanism in biodegradable photoluminescent polymers (BPLPs). Fluorescent labeling and imaging are in increasing demand for analyzing biomolecules, tracking biological processes, and visualizing diseases and therapeutic efficacy. Biodegradable polymers have been widely used in vivo biomedical implants, tissue engineering scaffolds, and orthopedic devices. However, none of the current biodegradable polymers can function as both implant materials and in vivo bioimaging probes without using exogenous imaging agents such as photobleaching organic dyes or toxic quantum dots. This project will establish a methodology to custom-design many types of BPLPs to meet the versatile needs for functional biodegradable polymers. Successful completion of this proposal is expected to significantly advance the biomaterials science and bring paradigm shifts in the use of biodegradable implant biomaterials in a broad range of biological and biomedical fields including biosensing, bioimaging, drug delivery, tissue engineering, and nanomedicine. The proposed education activities focus on establishing a team consisting of the PI, graduate students and high school teachers for high school curriculum enhancement. The PI and graduate students will train high school teachers in the PI's laboratory and they together will help to identify valuable educational tools that would enhance the existing high school curriculum. This teacher training program is expected to give high school teachers hands-on experience and provides latest scientific knowledge in biomaterials and tissue engineering.Biomaterials are critical components of biomedical devices and products. A novel biomaterial may create new fields of studies and opportunities to tackle unmet biomedical needs. Biodegradable polymers have been intensively used in many biomedical applications such as tissue engineering, drug delivery and orthopedic devices. The PI has recently developed a unique biodegradable polymer that can emit bright fluorescence by itself without adding toxic imaging agents in detecting early cancers, tracking cancer drug delivery process and monitoring medical implant performance. This proposal will explore the fundamental sciences of this fluorescent polymer, and then establish a methodology to custom-design many different types of fluorescent biodegradable polymers. In the educational area, high school students and teachers will be trained in the PI's laboratory with cutting-edge technologies and sciences in biomaterials and tissue engineering. This research effort by teachers and students is expected to identify valuable topics that could be used later to enhance the existing high school curriculum. This collaborative effort with the largest high school in Texas, Martin High School, Arlington, is expected to generate a wide scientific impact on the high school education.

生物材料计划在德克萨斯大学阿灵顿大学材料研究部的职业奖是为了设计，合成，表征和识别可生物降解的可生物发光聚合物（BPLP）中的荧光机制。荧光标记和成像正在增加分析生物分子，跟踪生物过程以及可视化疾病和治疗功效的需求。可生物降解的聚合物已被广泛用于体内生物医学植入物，组织工程支架和骨科设备。但是，当前可生物降解的聚合物既不能用作植入物材料，又可以充当体内生物成像探针，而无需使用外源成像剂，例如光漂白有机染料或有毒的量子点。该项目将建立一种定制多种类型的BPLP的方法，以满足功能性可生物降解聚合物的多功能需求。预计该提案的成功完成将显着提高生物材料科学，并在广泛的生物学和生物医学领域中使用可生物降解的植入物生物材料的使用范式转移，包括生物成像，生物成像，生物成像，药物递送，组织工程和纳米医学。拟议的教育活动着重于建立一个由PI，研究生和高中教师组成的团队，以增强高中课程。 PI和研究生将在PI实验室培训高中教师，他们将共同帮助确定有价值的教育工具，以增强现有的高中课程。预计该教师培训计划将为高中教师实践经验，并提供生物材料和组织工程学的最新科学知识。生物材料是生物医师设备和产品的关键组成部分。一种新颖的生物材料可能会创建新的研究领域和机会来满足未满足的生物医学需求。可生物降解的聚合物已在许多生物医学应用中进行了强烈使用，例如组织工程，药物递送和骨科设备。 PI最近开发了一种独特的可生物降解聚合物，可以自行发出明亮的荧光，而无需在检测早期癌症时添加有毒的成像剂，跟踪癌症药物输送过程和监测医疗植入物的性能。该建议将探讨该荧光聚合物的基本科学，然后建立一种定制许多不同类型的荧光生物降解聚合物的方法。在教育领域，高中生和教师将在PI的实验室接受培训，并在生物材料和组织工程中使用最先进的技术和科学。预计教师和学生的研究工作将确定有价值的主题，以后可以使用这些主题来增强现有的高中课程。与德克萨斯州最大的高中马丁高中（Arlington）的合作努力有望对高中教育产生广泛的科学影响。