NSF East Asia and Pacific Summer Institute (EAPSI) for FY 2013 in Japan

2013 财年 NSF 东亚及太平洋夏季学院 (EAPSI) 在日本举行

• 批准号: 1310869
• 负责人: Michael Schulz
• 金额: $ 0.51万
• 依托单位: Schulz Michael D
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1310869&HistoricalAwards=false
• 关键词: NSF; East; Asia; Pacific; Summer

This action funds Michael Schulz of the University of Florida to conduct a research project in the Math and Physical Sciences area during the summer of 2013 at Kyoto University in Kyoto, Japan. The project title is "Understanding the Connection between Binding and Molecular Architecture in Polymer-Metal Mixtures." The host scientist is Yoshiki Chujo.Polyethyleneimine-methylphosphonate (PEI-MP) is an anionic polymer--a negatively charged large molecule--that has been studied as a polymeric ligand to bind to certain metals, specifically radioactivce atoms, or radionuclides. However, the binding of PEI-MP to radionuclides is not understood at a fundamental level. This project is studying various potential binding configurations of the polymer system with a simplified, small molecule system. Isothermal titration calorimetry (ITC) is being used to measure the thermodynamic parameters of each binding mode. This information provides insight into which molecular configurations form the most stable coordinate complexes, i.e., which are the most effective at binding to different metals. Understanding the binding of PEI-MP at a fundamental level will allow the rational design and improvement of future polymeric radionuclide carriers. Broader impacts of an EAPSI fellowship include providing the Fellow a first-hand research experience outside the U.S.; an introduction to the science, science policy, and scientific infrastructure of the respective location; and an orientation to the society, culture and language. These activities meet the NSF goal to educate for international collaborations early in the career of its scientists, engineers, and educators, thus ensuring a globally aware U.S. scientific workforce. Furthermore, the Fellow has demonstrated a commitment to undergraduate education, involving undergraduate students in the scientific preparation required prior to the start of the EAPSI fellowship. He will include undergraduates in new research and collaborations that result from interactions with the host scientist as well.

这项行动为佛罗里达大学的迈克尔·舒尔茨（Michael Schulz）提供了2013年夏季在日本京都的京都大学的数学和物理科学领域进行研究项目。 项目标题是“了解聚合物 - 金属混合物中的结合和分子结构之间的联系”。宿主科学家是Yoshiki Chujo.poly-甲基胺 - 甲基膦酸酯（PEI-MP）是一种阴离子聚合物（一种带负电荷的大分子），该聚合物已被研究为一种聚合物配体以结合某些金属，特定的放射性抗活性原子，或radion核细胞。但是，在基本水平上，尚不清楚PEI-MP与放射性核素的结合。该项目正在研究使用简化的小分子系统的聚合物系统的各种潜在结合构型。等温滴定量热法（ITC）用于测量每种结合模式的热力学参数。该信息提供了有关哪种分子构构形成最稳定的坐标复合物，即最有效与不同金属结合的最稳定坐标复合物的信息。了解PEI-MP在基本水平上的结合将使未来聚合物放射性核素载体的合理设计和改进。 EAPSI奖学金的更广泛的影响包括为这位美国境外的第一手研究经验提供；各自位置的科学，科学政策和科学基础设施的简介；以及社会，文化和语言的方向。 这些活动符合NSF的目标，以在其科学家，工程师和教育工作者的职业生涯的早期对国际合作进行教育，从而确保全球意识的美国科学劳动力。 此外，该研究员表现出了对本科教育的承诺，在EAPSI奖学金开始之前，涉及本科生进行科学准备。他将在与东道科学家互动的新研究和合作中包括本科生。