Collaborative Research: CDS&E: Sculpting fluid flow using a programmed sequence of micro-pillars

合作研究：CDS

• 批准号: 1307743
• 负责人: Jaroslaw Zola
• 金额: $ 5.98万
• 依托单位: Rutgers University New Brunswick
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2014-10-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1307743&HistoricalAwards=false
• 关键词: Collaborative; Research; CDS& Sculpting; fluid

CBET 1306866/1307550/1307743Collaborative Research: CDS&E: Sculpting fluid flow using a programmed sequence of micro-pillarsPI(s) Ganapathysubramanian (Iowa State U.), DiCarlo (UCLA), Zola (Rutgers)Controlling the shape and location of a fluid stream provides a fundamental tool for creating structured materials, preparing biological samples, and engineering heat and mass transport. Methods to manipulate the cross-sectional shape of fluids have focused on creating chaos and mixing by fluid twisting instead of ordering or structuring streams with precise sequences of fluid perturbations. The ability to engineer the cross-sectional shape of a fluid using the integrated inertial flow deformations induced by sequences of simple microstructures (i.e. pillars) was recently demonstrated. Discretization of single pillar operations followed by their programmed superposition allows for the hierarchical assembly of complex flow programs. Although this approach has allowed for the sculpting of complex fluid shapes, creating user-defined flow shapes important for practical applications currently requires laborious and time-consuming trial and error design iterations, and often complex fluid shapes of interest are not achievable in a reasonable time frame. The ability to create a user-defined flow shape and automatically determine a sequence of pillars that yields this shape is a significant and impactful advance, which is ideally addressed by computational approaches. This challenge motivates the objectives of the CDS&E project: (i) Computationally explore and create a library of pillar-induced transformations annotated at different levels of granularity to aid in computational selection using parallel CFD simulations. (ii) Develop efficient computational methods to solve the inverse problem and select pillar sequences for a set of desired flow transformation. This part of the project will explore mathematical and computational issues related to uniqueness of solution sequences, scalable approaches to deal with the large libraries of pillar transformations, and choice of cost-functionals to enable efficient solution to the design problem. (iii) Test the computational framework and associated solutions by fabricating microfluidic designs with the defined pillar sequences that address three transformative applications in medicine and materials, including fabricating tailored cross-sectional polymer fibers, and capturing biomolecules on microchannel surfaces.The introduction of a general strategy to program fluid streams in which the complexity of the nonlinear equations of fluid motion are abstracted from the user can impact biological, chemical and materials automation in the same way that abstraction of semiconductor physics from computer programmers enabled a revolution in computation. As part of dissemination efforts, gaming and educational modules involving immersive simulations and directed rubix-cube like puzzles will be developed that will allow the public and interested parties to experiment with different pillar programs and learn about fluid mechanics and applications in a gaming environment. These outreach and workforce development activities will emphasize to the community the crucial role of computing in science and technology. This outreach will synergistically enable crowd-sourced design of complex flow transformations for applications that have a major impact on cell diagnostics, nano-materials fabrication, and thermal cooling.

CBET 1306866/1307550/1307743策略研究：CDS＆E：使用Micro-Pillarspi（S）Ganapathysubramanian（Iowa State U.）的编程序列雕刻流体流量准备生物样品以及工程热和质量运输。 操纵流体的横截面形状的方法已着重于产生混乱和通过流体扭曲而混合，而不是以精确的流体扰动序列进行订购或结构流。 最近证明了使用简单微观结构序列（即支柱）诱导的集成的惯性流变形来设计流体的横截面形状的能力。单支柱操作的离散化，然后进行编程的叠加，允许复杂流程计划的层次组装。 尽管这种方法允许雕刻复杂的流体形状，但是对于当前的实用应用来说，创建用户定义的流动形状需要费力且耗时的试验和错误设计迭代，并且通常在合理的时间范围内无法实现复杂的感兴趣的流体形状。 创建用户定义的流程形状并自动确定产生这种形状的一系列支柱的能力是一个重大且有影响力的进步，这是通过计算方法来解决的。这项挑战激发了CDS＆E项目的目标：（i）在计算上探索并创建了在不同级别的粒度级别注释的支柱诱导的转换库，以使用并行CFD模拟来帮助计算选择。 （ii）开发有效的计算方法来解决一组所需流动转换的逆问题并选择支柱序列。该项目的这一部分将探讨与解决方案序列的唯一性有关的数学和计算问题，可扩展的方法来处理大型支柱变换的库以及成本官方的选择，以实现有效解决设计问题的解决方案。 （iii）通过使用定义的支柱序列制造微流体设计来测试计算框架和相关的解决方案，该序列解决了医学和材料中的三个变革性应用，包括制造量身定制的横截面聚合物纤维，并捕获生物分子在微观通道表面上的生物分子。生物，化学和材料自动化的方式与计算机程序员的半导体物理学的抽象相同，从而实现了计算革命。作为传播努力的一部分，将开发涉及沉浸式模拟和定向Rubix-Cube（例如难题）的游戏和教育模块，这将使公众和感兴趣的各方能够尝试不同的支柱程序，并在游戏环境中了解流体机制和应用。这些宣传和劳动力发展活动将向社区强调计算在科学和技术中的关键作用。该外展将协同促进对细胞诊断，纳米材料制造和热冷却产生重大影响的应用的复杂流动转换设计的人群设计。