Ultraminiature Imaging Systems for Biomedical Applications

用于生物医学应用的超小型成像系统

• 批准号: 1265062
• 负责人: Armand Tanguay,Jr.
• 金额: $ 74.63万
• 依托单位: University of Southern California
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1265062&HistoricalAwards=false
• 关键词: Ultraminiature; Imaging; Systems; Biomedical; Applications

1265062TanguayThe fundamental goal of this potentially transformative research project is to investigate the feasibility of ultra compact optical imaging systems for ultraminiature cameras that are designed for chronic surgical implantation in the human body. Such ultraminiature cameras must be at once extremely small, very low mass, and very low power, as well as being both biocompatible and hermetically sealed for chronic implantation. Recent advances in biocompatible optical materials, optical systems design, and CMOS image sensor array technology potentially enable this extreme miniaturization. Biomedical imaging applications of such ultraminiature cameras include an intraocular camera for retinal prostheses, a wide field-of-view eye-tracked extraocular camera for retinal prostheses, a miniaturized eye-tracking camera, and bioimplantable cameras capable of post-surgical interrogation. In the intraocular camera application, the ultraminiature camera is designed for implantation within the human eye, with capability for partially restoring vision in those blinded by photoreceptor degenerating diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD). The intraocular camera is designed to couple directly to a pixellated microstimulator array that is proximity-coupled to the retinal surface. The development of such an ultraminiature intraocular camera (IOC) would eliminate the need for an external head-mounted or eyeglass-mounted camera in retinal prostheses, and provide for a completely implantable prosthetic device capable of restoring sight with foveation to the blind, at the same time relieving surgical complications.

1265062 Tanguay这个潜在的变革性研究项目的基本目标是研究用于人体慢性外科手术植入的超显影相机超紧凑的光学成像系统的可行性。这样的超显影摄像机必须立即非常小，质量非常低，功率非常低，并且既具有生物相容性且密封又密封以进行慢性植入。生物相容性光学材料，光学系统设计和CMOS图像传感器阵列技术的最新进展可能会实现这种极端的微型化。这种超显影相机的生物医学成像应用包括用于视网膜假体的眼内摄像机，视网膜假体的广泛视野视野传播的眼外摄像机，一个微型的醒目的摄像机以及能够生物启动的摄像机，可在后期询问。在眼内摄像头应用中，超显影摄像机设计用于植入人眼中，能够部分恢复受感光者退化性疾病（例如视网膜炎色素（RP）和年龄相关的黄斑变性（AMD））的视力。眼内摄像机设计为直接将其搭配到与视网膜表面接近耦合的像素的微刺激器阵列。这种超显影性摄像头（IOC）的开发将消除在视网膜假体中使用外部头部安装或眼镜安装的摄像机的需求，并提供完全可植入的假体设备，能够使视力恢复视力，并同时缓解手术外科手术。